A Haemodialysis Journey from the West to the East

Pai, Pearl

doi:10.1159/000444840

Cited by 4 publications

(4 citation statements)

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“…One of them has been the traditional punitive approach to medication errors 10. Our hospital has been commissioned to bring about international practices and safety culture as part of healthcare reform in China 7. Among them have been incident reporting and the non-punitive approach to error reporting.…”

Section: Discussionmentioning

confidence: 99%

“… 10 Our hospital has been commissioned to bring about international practices and safety culture as part of healthcare reform in China. 7 Among them have been incident reporting and the non-punitive approach to error reporting. They have enabled our staff to report incidents without fear of punishment and to learn from mistakes.…”

Section: Discussionmentioning

confidence: 99%

“…Our HD unit has been built within a public comprehensive hospital in the south of China and was awarded Australian Council of Health and Safety accreditation. 7 It has 50 dialysis stations where 200 patients with chronic HD are dialysed in 3 shifts. Typically, it gives a single bolus intravenous injection of dalteparin at 60 IU per kg body weight before dialysis.…”

Section: Introductionmentioning

confidence: 99%

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Quality improvement project to enhance heparin safety in patients with haemodialysis in China

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quality improvement project to enhance heparin safety in patients with haemodialysis in China

et al. 2022

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“…The Chinese population differs from Western and Japanese populations in terms of race and ethnicity, including differences in dietary habits [ 18 ], medical practice patterns, and available medications [ 19 ]. An increasing number of patients in China are initiating dialysis [ 20 ], and there is a need to improve the control of sP levels [ 21 ]; Chinese dialysis patients were shown to have a higher mean sP level, with a lower proportion having target-range sP and a higher proportion having severe hyperphosphataemia compared with other world regions [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Sucroferric Oxyhydroxide Compared with Sevelamer Carbonate in Chinese Dialysis Patients with Hyperphosphataemia: A Randomised, Open-Label, Multicentre, 12-Week Phase III Study

Lee¹,

Zuo²,

Walpen³

et al. 2023

Nephron

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Introduction: This study aimed to investigate the efficacy and safety of sucroferric oxyhydroxide (SFOH) versus sevelamer carbonate in controlling serum phosphorus (sP) in adult Chinese dialysis patients with hyperphosphataemia (sP >1.78 mmol/L). Methods: Open-label, randomised (1:1), active-controlled, parallel group, multicentre, phase III study of SFOH and sevelamer at starting doses corresponding to 1,500 mg iron/day and 2.4 g/day, respectively, with 8-week dose titration and 4-week maintenance (NCT03644264). Primary endpoint was non-inferiority analysis of change in sP from baseline to week 12. Secondary endpoints included sP over time and safety. Results: 415 patients were screened; 286 were enrolled and randomised (142 and 144 to SFOH and sevelamer, respectively). Mean (SD) baseline sP: 2.38 (0.57) and 2.38 (0.52) mmol/L, respectively. Mean (SD) change in sP from baseline to week 12: – 0.71 (0.60) versus −0.63 (0.52) mmol/L, respectively; difference (sevelamer minus SFOH) in least squares means (95% CI): 0.08 mmol/L (−0.02, 0.18) with the lower limit of 95% CI above the non-inferiority margin of −0.34 mmol/L. The SFOH group achieved target sP (1.13–1.78 mmol/L) earlier than the sevelamer group (56.5% vs. 32.8% at week 4) and with a lower pill burden (mean 3.7 vs. 9.1 tablets/day over 4 weeks of maintenance, respectively). Safety and tolerability of SFOH was consistent with previous studies, and no new safety signals were observed. Conclusion: SFOH effectively reduced sP from baseline and was non-inferior to sevelamer after 12 weeks of treatment but had a lower pill burden in Chinese dialysis patients with hyperphosphataemia; SFOH benefit-risk profile is favourable in Chinese patients.

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Predictors of Primary Functional Maturation of Autogenous Radiocephalic Arteriovenous Fistula in a Cohort of Asian Patients

Chan

Cui

et al. 2020

Annals of Vascular Surgery

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A Haemodialysis Journey from the West to the East

Cited by 4 publications

References 4 publications

Quality improvement project to enhance heparin safety in patients with haemodialysis in China

Quality improvement project to enhance heparin safety in patients with haemodialysis in China

Efficacy and Safety of Sucroferric Oxyhydroxide Compared with Sevelamer Carbonate in Chinese Dialysis Patients with Hyperphosphataemia: A Randomised, Open-Label, Multicentre, 12-Week Phase III Study

Predictors of Primary Functional Maturation of Autogenous Radiocephalic Arteriovenous Fistula in a Cohort of Asian Patients

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