2016
DOI: 10.1186/s40064-016-2904-z
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Role of chemokine C-C motif ligand-1 in acute and chronic pulmonary inflammations

Abstract: BackgroundChemokine C-C motif ligand 1 (CCL1) accumulates C-C motif chemokine receptor 8 positive leukocytes to the inflammatory sites. Single-nucleotide polymorphisms in the chemokine CCL1 gene are associated with exacerbation of chronic obstructive lung disease. However, it is unclear whether CCL1 has immunomodulatory functions during pulmonary inflammation. This study aimed to elucidate this issue using newly generated transgenic mice that express CCL1 in the lungs (SPC-CCL1 mice).MethodsTo evaluate the phe… Show more

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Cited by 7 publications
(4 citation statements)
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“…CCL1 is a chemokine produced by activated monocytes/macrophages, T lymphocytes, and endothelial cells that mainly is a chemoattractant for monocytes/macrophages, lymphocytes, and neutrophils 28–32 . It is thought to play a major role in inflammatory processes, 33 and given the results of the experiments in this study, PLLA may induce CCL1 expression by macrophage activation. MIP‐1α (also known as CCL3) is an inflammatory, chemotactic chemokine known to be secreted by macrophages that recruits inflammatory cells, promotes wound healing, and maintains the effector immune response.…”
Section: Discussionmentioning
confidence: 68%
“…CCL1 is a chemokine produced by activated monocytes/macrophages, T lymphocytes, and endothelial cells that mainly is a chemoattractant for monocytes/macrophages, lymphocytes, and neutrophils 28–32 . It is thought to play a major role in inflammatory processes, 33 and given the results of the experiments in this study, PLLA may induce CCL1 expression by macrophage activation. MIP‐1α (also known as CCL3) is an inflammatory, chemotactic chemokine known to be secreted by macrophages that recruits inflammatory cells, promotes wound healing, and maintains the effector immune response.…”
Section: Discussionmentioning
confidence: 68%
“…3g and Supplementary Data 4 ). Studies have shown that increased expression of Ccl1 is associated with increased endoplasmic reticulum stress and granuloma formation during mycobacterial treatment 63 . Further, it has been reported that elevated plasma levels of Ccl1, Ccl3, Cxcl1, Cxcl9, and Cxcl10 correlate with disease severity in infected individuals 64 .…”
Section: Resultsmentioning
confidence: 99%
“…Fractalkine is a chemokine that binds to its receptor on the surface of macrophages and functions as a modulator of macrophage proliferation and differentiation into proinflammatory M1, as well as production of pro-inflammatory cytokines [64,65]. CCL1 is a chemokine that functions as chemoattractant of leukocytes to inflammation sites and has been implicated in several diseases, making it a potential therapeutic target for inflammation-related diseases [66][67][68][69]. However, a recent study also observed that CCL1 as a ligand of chemokine receptor CCR8 could have protective effect against intestinal colitis [70].…”
Section: Discussionmentioning
confidence: 99%