Understanding the controversy surrounding the correlation between fibrinogen level and prognosis of coronary artery disease—The role of the subtypes of coronary artery disease

Peng, Yong; Li, Yiming; Chai, Hua; Zuo, Zhi‐Liang; Wang, Pengju; Gui, Yi‐Yue; Huang, Bao‐Tao; Liao, Yanbiao; Xia, Tianli; Huang, Fang‐Yang; Liu, Wei; Zhang, Chen; Pu, Xiaobo; Chen, Shijian; Chen, Mao; Huang, Dejia

doi:10.1016/j.ijcard.2016.07.160

Cited by 5 publications

(6 citation statements)

References 16 publications

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“…hs-CRP is an indicator of inflammatory state, and the level of hs-CRP can change with the characteristics of coronary plaque, which is a predictor of coronary disease-related mortality [ 25 ]. FIB can promote the proliferation of vascular smooth muscle cells and the formation of atherosclerotic plaques, which is an indicator of thrombosis [ 26 ]. There have been many studies on IL-18, MMP-9, hs-CRP, and FIB in ACS in the past.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Correlation Analysis of Acute Coronary Syndrome with Serum IL‐18, MMP‐9, hs‐CRP, and Plasma FIB

Yang

Zhang

2022

BioMed Research International

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Aim. This study attempted to investigate the diagnostic value of interleukin-18 (IL-18), matrix metalloproteinase-9 (MMP-9), high-sensitivity C-reactive protein (hs-CRP), and fibrinogen (FIB) in acute coronary syndrome (ACS) and their correlation with the degree of vascular lesions. Materials and Methods. Altogether 206 patients with coronary heart disease admitted to our hospital were selected as research objects, including 136 patients with ACS (group A), 70 patients with stable angina pectoris (SAP) (group B), and 60 patients with noncoronary heart disease who had normal coronary angiography during the same period were selected as group C. The levels of IL-18, MMP-9, and hs-CRP in the serum were detected by enzyme-linked immunosorbent assay (ELISA), and the level of FIB in plasma was detected by automatic coagulation analyzer. Results. Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels in group A were significantly higher than those in group B and group C ( p < 0.05 ). ROC curve and multivariate logistic regression showed that the sensitivity and specificity of combined diagnosis of ACS with serum IL-18, MMP-9, hs-CRP, and plasma FIB were 86.03% and 95.71%, respectively. Serum IL-18, MMP-9, hs-CRP, and plasma FIB were positively correlated with Gensini grading ( p < 0.001 ). Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels were positively correlated ( p < 0.001 ). Conclusion. The combined detection of serum IL-18, MMP-9, hs-CRP, and plasma FIB has good diagnostic value for ACS, and these index levels are positively correlated with the degree of vascular lesions.

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Section: Discussionmentioning

confidence: 99%

[Retracted] Correlation Analysis of Acute Coronary Syndrome with Serum IL‐18, MMP‐9, hs‐CRP, and Plasma FIB

Yang

Zhang

2022

BioMed Research International

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“…Subtypes of CAD may affect the association of fibrinogen level with clinical prognosis. [ 17 ] Our subgroup analysis showed that the prognostic value of fibrinogen level in predicting MACEs was statistically significant in stable CAD patients but not in those with ACS. However, whether fibrinogen has a distinct effect on the prognosis of the subtypes of ACS should be further investigated in future studies.…”

Section: Discussionmentioning

confidence: 84%

“…There was no significant heterogeneity across the studies ( I 2 = 5.2%; P = .377). Five studies [ 9 , 11 , 17 , 18 , 22 ] provided data on association of elevated fibrinogen level with all-cause mortality (Fig. 3 B).…”

Section: Resultsmentioning

confidence: 99%

“…1). Finally, 15 articles (13 studies) [7][8][9][10][11][12][14][15][16][17][18][19][20][21][22] were included in the meta-analysis.…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

“…The included articles were published from 2000 to 2021. Six articles [11,14,[16][17][18][19] were the retrospective studies and others adopted prospective designs. The follow-up duration ranged from 1.4 to 10 years.…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

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Blood fibrinogen level as a biomarker of adverse outcomes in patients with coronary artery disease: A systematic review and meta-analysis

2022

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Background: The association between elevated fibrinogen level and adverse outcomes in patients with coronary artery disease (CAD) remains conflicting. This systematic review and meta-analysis aims to evaluate the association between fibrinogen level and adverse outcomes in CAD patients.Methods: Relevant studies were identified by searching PubMed, Web of Science, and Embase databases from their inception to September 30, 2021. Observational studies that investigated the association of blood fibrinogen level with cardiovascular death, all-cause mortality, and major adverse cardiovascular events were eligible.Results: A total of 20,395 CAD patients from 15 articles (13 studies) were included. Comparison with the highest and the lowest fibrinogen level indicated that elevated fibrinogen level was associated with higher risk of cardiovascular death (risk ratio [RR] 2.24; 95% confidence interval [CI] 1.69-2.98), all-cause mortality (RR 1.88; 95% CI 1.50-2.36), and major adverse cardiovascular events (RR 1.46; 95% CI 1.18-1.81).Conclusion: Elevated fibrinogen level is significantly associated with an increased risk of cardiovascular and all-cause mortality in patients with CAD. Baseline fibrinogen level can serve as a promising biomarker for risk stratification of CAD.

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U-Shaped Relationship Between Fibrinogen Level and 10-year Mortality in Patients With Acute Coronary Syndrome: Prospective Cohort Study

Li,

Jia,

Bai

et al. 2024

JMIR Public Health Surveill

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Understanding the controversy surrounding the correlation between fibrinogen level and prognosis of coronary artery disease—The role of the subtypes of coronary artery disease

Cited by 5 publications

References 16 publications

[Retracted] Correlation Analysis of Acute Coronary Syndrome with Serum IL‐18, MMP‐9, hs‐CRP, and Plasma FIB

[Retracted] Correlation Analysis of Acute Coronary Syndrome with Serum IL‐18, MMP‐9, hs‐CRP, and Plasma FIB

Blood fibrinogen level as a biomarker of adverse outcomes in patients with coronary artery disease: A systematic review and meta-analysis

U-Shaped Relationship Between Fibrinogen Level and 10-year Mortality in Patients With Acute Coronary Syndrome: Prospective Cohort Study

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