Hybrid materials for bone tissue engineering from biomimetic growth of hydroxiapatite on cellulose nanowhiskers

Fragal, Elizângela H.; Cellet, Thelma S.P.; Fragal, Vanessa H.; Companhoni, Mychelle Vianna Pereira; Ueda-Nakamura, Tânia; Muniz, Edvani C.; Rubira, Adley F.

doi:10.1016/j.carbpol.2016.07.063

Cited by 56 publications

(24 citation statements)

References 39 publications

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“…It is clear that the surface morphology of AHEC coated AZ31 is a uniform and dense structure compared with the untreated of AZ31. Scratches are not observed in AHEC/AZ31 surface, which contrasts Fragal's result [38]. The surface of the HA/AHEC-coated AZ31 samples is flower-like and homogeneous.…”

Section: Cell Viability Assay and Cell Morphology Examinationcontrasting

confidence: 79%

“…On the AHEC coating, the cracks and pits become smaller with many dense and spherical HA particles. This may be the AHEC inducing HA formation in SBF [38]. However, the surface of HA/AHEC/AZ31 shows the fewest cracks and pits with a more narrow and shallow structure.…”

Section: Cell Viability Assay and Cell Morphology Examinationmentioning

confidence: 93%

“…The material characterization results confirm the hydroxyapatite coating is formed on the AZ31 magnesium alloy. Some scholars [38,45] suggest that the formation is due to the hydroxyl groups of AHEC adsorbing Ca 2+ in solution. This forms positively charged groups of the surface.…”

Section: Characterization Of the Samples Surfacesmentioning

confidence: 99%

Section: Cytotoxicity Evaluationmentioning

confidence: 99%

“…It can be concluded that the HA/AHEC coating is a bioactive film, which can apparently promote the proliferation of MC3T3-E1 cells. It may be that the hydroxyapatite dissolved liquid has acceleration for MC3T3-E1cell proliferation and differentiation [38]. Inverted microscope images (20×) for the MC3T3-E1 cells cultured with extracts originated from AZ31 (Figure 8a), AHEC/AZ31 (Figure 8b), and HA/AHEC/AZ31 (Figure 8c) specimens, and the negative control group (Figure 8d) for 7d are presented in Figure 8.…”

Section: Cytotoxicity Evaluationmentioning

confidence: 99%

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Preparation and Characterization of Aminated Hydroxyethyl Cellulose-Induced Biomimetic Hydroxyapatite Coatings on the AZ31 Magnesium Alloy

Zhu

Sun

et al. 2017

Metals

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Abstract:The purpose of this work is to improve the cytocompatibility and corrosion resistance of magnesium alloy in the hope of preparing a biodegradable medical material. The aminated hydroxyethyl cellulose-induced biomimetic hydroxyapatite coating was successfully prepared on AZ31 magnesium alloy surface with a sol-gel spin coating method and biomimetic mineralization. Potentiodynamic polarization tests and electrochemical impedance spectroscopy showed that the hydroxyapatite/aminated hydroxyethyl cellulose (HA/AHEC) coating can greatly improve the corrosion resistance of AZ31 magnesium alloy and reduce the degradation speed in simulated body fluid (SBF). The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide] method and cell morphology observation results showed that the HA/AHEC coating on AZ31 magnesium alloy has excellent cytocompatibility and biological activity.

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Section: Cell Viability Assay and Cell Morphology Examinationcontrasting

confidence: 79%

Section: Cell Viability Assay and Cell Morphology Examinationmentioning

confidence: 93%

Section: Characterization Of the Samples Surfacesmentioning

confidence: 99%

Section: Cytotoxicity Evaluationmentioning

confidence: 99%

Section: Cytotoxicity Evaluationmentioning

confidence: 99%

See 3 more Smart Citations

Preparation and Characterization of Aminated Hydroxyethyl Cellulose-Induced Biomimetic Hydroxyapatite Coatings on the AZ31 Magnesium Alloy

Zhu

Sun

et al. 2017

Metals

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Carbohydrate‐Based Materials in Tissue Engineering Applications

Rostami¹

2021

Nanoengineering of Biomaterials

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Mechanistically Scoping Cell‐Free and Cell‐Dependent Artificial Scaffolds in Rebuilding Skeletal and Dental Hard Tissues

Xiang

et al. 2022

Advanced Materials

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Rebuilding mineralized tissues in skeletal and dental systems remains costly and challenging. Despite numerous demands and heavy clinical burden over the world, sources of autografts, allografts, and xenografts are far limited, along with massive risks including viral infections, ethic crisis, and so on. Per such dilemma, artificial scaffolds have emerged to provide efficient alternatives. To date, cell‐free biomimetic mineralization (BM) and cell‐dependent scaffolds have both demonstrated promising capabilities of regenerating mineralized tissues. However, BM and cell‐dependent scaffolds have distinctive mechanisms for mineral genesis, which makes them methodically, synthetically, and functionally disparate. Herein, these two strategies in regenerative dentistry and orthopedics are systematically summarized at the level of mechanisms. For BM, methodological and theoretical advances are focused upon; and meanwhile, for cell‐dependent scaffolds, it is demonstrated how scaffolds orchestrate osteogenic cell fate. The summary of the experimental advances and clinical progress will endow researchers with mechanistic understandings of artificial scaffolds in rebuilding hard tissues, by which better clinical choices and research directions may be approached.

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Hybrid materials for bone tissue engineering from biomimetic growth of hydroxiapatite on cellulose nanowhiskers

Cited by 56 publications

References 39 publications

Preparation and Characterization of Aminated Hydroxyethyl Cellulose-Induced Biomimetic Hydroxyapatite Coatings on the AZ31 Magnesium Alloy

Preparation and Characterization of Aminated Hydroxyethyl Cellulose-Induced Biomimetic Hydroxyapatite Coatings on the AZ31 Magnesium Alloy

Carbohydrate‐Based Materials in Tissue Engineering Applications

Mechanistically Scoping Cell‐Free and Cell‐Dependent Artificial Scaffolds in Rebuilding Skeletal and Dental Hard Tissues

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