Pneumonia presenting with organ dysfunctions: Causative microorganisms, host factors and outcome

Menéndez, Rosário; Montull, Beatriz; Reyes, Soledad; Amara-Elori, Isabel; Zalacaín, Rafael; Capelastegui, Alberto; Aspa, Javier; Borderías, Luis; Martín-Villasclaras, Juan José; Bello, Salvador; Alfageme, Inmaculada; Castro, Felipè Rodríguez de; Rello, Jordi; Molinos, Luis; Ruiz-Manzano, Juan; Torres, Antoni

doi:10.1016/j.jinf.2016.08.001

Cited by 25 publications

(19 citation statements)

References 33 publications

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“…Blood culture yield increases in severe pneumonia needing ICU admissions and in those with risk factors such as asplenia, chronic liver diseases, leukopenia and alcoholism. In these situations, blood culture positivity goes up to 33 per cent 72 . Bacteria associated with SCAP such as S. aureus , S. pneumoniae , Enterobacteriaceae and Pseudomonas are likewise responsible for bacteraemia.…”

Section: Microbiological Diagnostics In Cabp-bridging Ideal and Real mentioning

confidence: 99%

Community-acquired bacterial pneumonia in adults: An update

2020

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Community-acquired pneumonia (CAP) is the prominent cause of mortality and morbidity with important clinical impact across the globe. India accounts for 23 per cent of global pneumonia burden with case fatality rates between 14 and 30 per cent, and Streptococcus pneumoniae is considered a major bacterial aetiology. Emerging pathogens like Burkholderia pseudomallei is increasingly recognized as an important cause of CAP in Southeast Asian countries. Initial management in the primary care depends on clinical assessment while the hospitalized patients require combinations of clinical scores, chest radiography and various microbiological and biomarker assays. This comprehensive diagnostic approach together with additional sampling and molecular tests in selected high-risk patients should be practiced. Inappropriate therapy in CAP in hospitalized patients lengthens hospital stay and increases cost and mortality. In addition, emergence of multidrug-resistant organisms poses tough challenges in deciding empirical as well as definitive therapy. Developing local evidence on the cause and management should be a priority to improve health outcomes in CAP.

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Section: Microbiological Diagnostics In Cabp-bridging Ideal and Real mentioning

confidence: 99%

Community-acquired bacterial pneumonia in adults: An update

2020

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“…In Spain, there is a general lack of knowledge about CAP and, particularly, of its impact on population's health. There is a widespread misperception that CAP affects only specific subgroups of susceptible individuals: in some people, CAP may be associated with only a few clinical symptoms but in others, it may present as a fulminant systemic infection causing respiratory failure, multiple organ dysfunction, and death [26,27]. In a German study assessing knowledge of sepsis among the elderly population (≥65 years old) through a telephone survey of 1401 persons, 89% had heard the term "sepsis" before the survey, but 39% could not identify a correct definition, while 98% were familiar with the term "blood poisoning" [28].…”

Section: Cap Affects Everyone: Why Do We Not Recognize the Threat?mentioning

confidence: 99%

Defining Community-Acquired Pneumonia as a Public Health Threat: Arguments in Favor from Spanish Investigators

et al. 2020

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Despite advances in its prevention, pneumonia remains associated with high morbidity, mortality, and health costs worldwide. Studies carried out in the last decade have indicated that more patients with community-acquired pneumonia (CAP) now require hospitalization. In addition, pneumonia management poses many challenges, especially due to the increase in the number of elderly patients with multiple comorbidities, antibiotic-resistant pathogens, and the difficulty of rapid diagnosis. In this new call to action, we present a wide-ranging review of the information currently available on CAP and offer some reflections on ways to raise awareness of this disease among the general public. We discuss the burden of CAP and the importance of attaining better, faster microbiological diagnosis and initiating appropriate treatment. We also suggest that closer cooperation between health professionals and the population at large could improve the management of this largely preventable infectious disease that takes many lives each year.

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“…A prospective multicenter study in Asia reported that the mortality rate of CAP in Asia was as high as 7.3% [3]. Several factors are associated with the risk of CAP mortality, including in ammatory response, cardiovascular complications, and etiology [4][5][6]. Some studies identi ed age and male sex increases the incidence of CAP [7,8].…”

Section: Introductionmentioning

confidence: 99%

Clinical features and etiology of patients with community-acquired pneumonia in southern China

Gan

Liu

Guo

et al. 2020

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Background: The aim of this study was to investigate the clinical features and etiology in patients with community-acquired pneumonia (CAP) in southern China. Methods: A total of 342 patients who presented community-acquired pneumonia (CAP) from January 2019 to December 2019 were enrolled in this study. The respiratory pathogens in nine test and loop-mediated isothermal amplification (LAMP) detection were used to identify pathogens. Results: The mean age of this study population was 60.89 ± 18.87 years. The total incidences of CAP were more prevalent in males (60.5%, 207/342) than females (39.5%, 135/342), and the percentage was 65.8% (225/342) CAP patients in summer and autumn. The main causative pathogens were identified in 96/342 (28.1 %) patients. Of these, 14 (14.6 %) were MP infection, the most frequently isolated microorganism. Bacterial infection in the single infection was present in 47 (47/96, 49.0%). Mixed infections were demonstrated in 26 (26/96, 27.1%). MRSA infection was close to patients with systemic diseases (P = 0.001). Factors that were associated with systemic disease was the age >65 (OR 5.555, 95%CI 3.402-9.071, P<0.001). Conclusions: MP is common organisms isolated in community-acquired pneumonia. The year of above 65, the count of WBC and mixed pathogens infections may be associated with an increased risk of CAP patients with systemic disease.

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Pneumonia presenting with organ dysfunctions: Causative microorganisms, host factors and outcome

Cited by 25 publications

References 33 publications

Community-acquired bacterial pneumonia in adults: An update

Community-acquired bacterial pneumonia in adults: An update

Defining Community-Acquired Pneumonia as a Public Health Threat: Arguments in Favor from Spanish Investigators

Clinical features and etiology of patients with community-acquired pneumonia in southern China

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