Core Outcomes for Colorectal Cancer Surgery: A Consensus Study

McNair, Angus G K; Whistance, Robert N.; Forsythe, Rachael; Macefield, Rhiannon; Rees, John; Pullyblank, Anne; Avery, Kerry; Brookes, Sara; Thomas, Michael G.; Sylvester, P. A.; Russell, Ann; Oliver, Alfred; Morton, Dion; Kennedy, Robin H.; Jayne, David; Huxtable, Richard; Hackett, R; Dutton, Susan; Coleman, Mark; Card, M.; Brown, Julia; Blazeby, Jane M

doi:10.1371/journal.pmed.1002071

Cited by 91 publications

(91 citation statements)

References 20 publications

(20 reference statements)

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“…Colorectal cancer (CRC), one of the most common digestive track tumors, remains the third leading cause of cancer-related mortality in both sexes worldwide and presents a great burden for both individuals and society as a whole [1]. Despite recent advances in modern medical technology CRC remains a disease with high mortality due to local relapse, distant metastases and resistance to chemotherapy [2, 3].…”

Section: Introductionmentioning

confidence: 99%

Osteopontin Promotes Cell Migration and Invasion, and Inhibits Apoptosis and Autophagy in Colorectal Cancer by activating the p38 MAPK Signaling Pathway

Huang

Quan

Chen

et al. 2017

Cell Physiol Biochem

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Background: Osteopontin (OPN) is highly expressed in colorectal cancer (CRC) and is associated with disease progression in vivo. High levels of OPN have been demonstrated to predict low survival rates in CRC. Autophagy is a process of self-digestion, which is thought to play a significant role in carcinogenesis. However, the mechanisms of OPN's effects on CRC cell autophagy have not been elucidated. Therefore, we aimed to investigate possible mechanisms of OPN's effects on CRC autophagy. Methods: HCT116 cell proliferation, apoptosis, and migration and invasion ability were identified by cell counting k¡t-8 assay, flow cytometry, wound healing assay, and transwell chamber invasion assay, respectively. The ratios of proteins LC3-II/LC3-I, P62, and Atg7 were analyzed by Western-blot. Expressions of Beclin-1, Atg4b, Bnip3, and Vps34, both in transcriptional and translational levels, were analyzed and compared by RT-PCR and Western blot. Immunofluorescence and co-focusing experiments were used to investigate the formation of autophagosomes. Results: The results showed that OPN can promote cell proliferation, migration, and invasion, as well as inhibit cell apoptosis. It was also demonstrated that OPN could inhibit cell autophagy. Further experiments revealed that the inhibitory effect of OPN on autophagy could be reversed by blocking the p38 MAPK pathway in HCT116 cells. Conclusion: OPN is involved in HCT116 cell progression and is capable of inhibiting cell autophagy possibly by activating the p38 MAPK signaling pathway, implying that OPN could be a potential novel molecular therapeutic biomarker in patients with CRC.

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Section: Introductionmentioning

confidence: 99%

Osteopontin Promotes Cell Migration and Invasion, and Inhibits Apoptosis and Autophagy in Colorectal Cancer by activating the p38 MAPK Signaling Pathway

Huang

Quan

Chen

et al. 2017

Cell Physiol Biochem

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“…As methodological guidelines for the development of COS have not yet been completely established, the design of the e‐Delphi study was based on general recommendations for Delphi methodology and the methods of other published COS studies . The results of this study were reported according to the Core Outcome Set‐STAndards for Reporting (COS‐STAR) checklist …”

Section: Methodsmentioning

confidence: 99%

Development of an international core outcome set for peripheral vascular malformations: the OVAMA project

et al. 2018

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“…Consequently, clinicians and researchers have been urged to look beyond survival and recurrence as the sole measures of treatment success . Core outcomes sets that specify a minimum set of outcomes to be measured, have been proposed to reduce heterogeneity of outcome reporting and reporting bias in clinical trials . The proposed core outcomes sets for colorectal cancer surgery includes quality of life and functional outcomes, highlighting the importance of these outcomes …”

Section: Introductionmentioning

confidence: 99%

“…6 Core outcomes sets that specify a minimum set of outcomes to be measured, have been proposed to reduce heterogeneity of outcome reporting and reporting bias in clinical trials. 7 The proposed core outcomes sets for colorectal cancer surgery includes quality of life and functional outcomes, highlighting the importance of these outcomes. 7 The term low anterior resection syndrome (LARS) describes 'disordered bowel function after rectal resection, leading to a detriment in quality of life'.…”

Section: Introductionmentioning

confidence: 99%

International consensus definition of low anterior resection syndrome

Keane

Fearnhead

Bordeianou

et al. 2020

ANZ Journal of Surgery

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Background Low anterior resection syndrome (LARS) is pragmatically defined as disordered bowel function after rectal resection leading to a detriment in quality of life. This broad characterization does not allow for precise estimates of prevalence. The LARS score was designed as a simple tool for clinical evaluation of LARS. Although the LARS score has good clinical utility, it may not capture all important aspects that patients may experience. The aim of this collaboration was to develop an international consensus definition of LARS that encompasses all aspects of the condition and is informed by all stakeholders. Methods This international patient‐provider initiative used an online Delphi survey, regional patient consultation meetings and an international consensus meeting. Three expert groups participated: patients, surgeons and other health professionals from five regions (Australasia, Denmark, Spain, Great Britain and Ireland, and North America) and in three languages (English, Spanish and Danish). The primary outcome measured was the priorities for the definition of LARS. Results Three hundred and twenty‐five participants (156 patients) registered. The response rates for successive rounds of the Delphi survey were 86%, 96% and 99%. Eighteen priorities emerged from the Delphi survey. Patient consultation and consensus meetings refined these priorities to eight symptoms and eight consequences that capture essential aspects of the syndrome. Sampling bias may have been present, in particular, in the patient panel because social media was used extensively in recruitment. There was also dominance of the surgical panel at the final consensus meeting despite attempts to mitigate this. Conclusions This is the first definition of LARS developed with direct input from a large international patient panel. The involvement of patients in all phases has ensured that the definition presented encompasses the vital aspects of the patient experience of LARS. The novel separation of symptoms and consequences may enable greater sensitivity to detect changes in LARS over time and with intervention.

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Core Outcomes for Colorectal Cancer Surgery: A Consensus Study

Abstract: Background

Cited by 91 publications

References 20 publications

Osteopontin Promotes Cell Migration and Invasion, and Inhibits Apoptosis and Autophagy in Colorectal Cancer by activating the p38 MAPK Signaling Pathway

Osteopontin Promotes Cell Migration and Invasion, and Inhibits Apoptosis and Autophagy in Colorectal Cancer by activating the p38 MAPK Signaling Pathway

Development of an international core outcome set for peripheral vascular malformations: the OVAMA project

International consensus definition of low anterior resection syndrome

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