Environmental and mucosal microbiota and their role in childhood asthma

Birzele, Lena Teresa; Depner, Martin; Ege, Markus; Engel, Marion; Kublik, Susanne; Bernau, Christoph; Loss, Georg; Genuneit, Jon; Horak, Elisabeth; Schloter, Michael; Braun-Fahrländer, C.; Danielewicz, Hanna; Heederik, Dick; Mutius, Erika von; Legatzki, Antje

doi:10.1111/all.13002

Cited by 98 publications

(101 citation statements)

References 46 publications

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“…So far, the main farm‐related exposures involved in the protective farm effect on asthma and allergies have been found in consumption of farm milk and exposure to cattle and animal sheds, or more precisely endotoxin and microorganisms . These findings were also replicated in the large GABRIEL Advanced (GABRIELA) studies …”

Section: Introductionmentioning

confidence: 78%

An approach to the asthma‐protective farm effect by geocoding: Good farms and better farms

Müller-Rompa¹,

Markevych

Hose³

et al. 2018

Pediatric Allergy Immunology

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Section: Introductionmentioning

confidence: 78%

An approach to the asthma‐protective farm effect by geocoding: Good farms and better farms

Müller-Rompa¹,

Markevych

Hose³

et al. 2018

Pediatric Allergy Immunology

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“…The human microbiome can be affected by contact with surfaces, animals (25, 26), and other people; ingestion of food and water; or inhalation (27, 28). Conversely, the gut microbiota may also affect resistance to environmental exposures to parasites and other pathogens by altering innate and adaptive immunity, and through effects on the gut mucosa (29).…”

Section: Key Aspects Of One Health Microbiome Relationshipsmentioning

confidence: 99%

“…Infants with fewer microbial exposures, such as those experiencing C-section births and urbanized environments, have been found to have higher asthma and allergy risk compared to children growing up on farms, supporting the “hygiene hypothesis” (54). The microbiome of dust samples has been found to differ between houses of children with and without asthma (27), and the diversity of a house dust microbial community can be a predictor of asthmatic status in children residing in that household (28). Gnotobiotic mouse models support the causal effects of non-pathogenic microbial transmission on host health.…”

Section: Key Aspects Of One Health Microbiome Relationshipsmentioning

confidence: 99%

One Health Relationships Between Human, Animal, and Environmental Microbiomes: A Mini-Review

Trinh

Zaneveld

Safranek

et al. 2018

Front. Public Health

136

101

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The One Health concept stresses the ecological relationships between human, animal, and environmental health. Much of the One Health literature to date has examined the transfer of pathogens from animals (e.g., emerging zoonoses) and the environment to humans. The recent rapid development of technology to perform high throughput DNA sequencing has expanded this view to include the study of entire microbial communities. Applying the One Health approach to the microbiome allows for consideration of both pathogenic and non-pathogenic microbial transfer between humans, animals, and the environment. We review recent research studies of such transmission, the molecular and statistical methods being used, and the implications of such microbiome relationships for human health. Our review identified evidence that the environmental microbiome as well as the microbiome of animals in close contact can affect both the human microbiome and human health outcomes. Such microbiome transfer can take place in the household as well as the workplace setting. Urbanization of built environments leads to changes in the environmental microbiome which could be a factor in human health. While affected by environmental exposures, the human microbiome also can modulate the response to environmental factors through effects on metabolic and immune function. Better understanding of these microbiome interactions between humans, animals, and the shared environment will require continued development of improved statistical and ecological modeling approaches. Such enhanced understanding could lead to innovative interventions to prevent and manage a variety of human health and disease states.

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“…European farm studies have linked both the environmental and the host microbiome to asthma [24,25]. Asthma was associated with an altered nasal, but not throat, microbiota that was characterized by lower diversity and an abundance of Moraxella [24].…”

Section: Asthma and The Farm Effectmentioning

confidence: 99%

“…Asthma was associated with an altered nasal, but not throat, microbiota that was characterized by lower diversity and an abundance of Moraxella [24]. Farm exposure in turn was positively associated with bacterial diversity in mattress dust samples as determined by richness ( P = 8.1×10 −6 ); asthma was inversely associated with richness (aOR= 0.48 [0.22–1.02]) in mattress dust and to a lower extent to richness in nasal samples (richness aOR 0.63 [0.38–1.06]) [25]. …”

Section: Asthma and The Farm Effectmentioning

confidence: 99%

Immune development and environment: lessons from Amish and Hutterite children

Ober

Sperling

Mutius

et al. 2017

Current Opinion in Immunology

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Children who grow up in traditional farm environments are protected from developing asthma and allergy. This “farm effect” can be largely explained by the child’s early life contact with farm animals, in particular cows, and their microbes. Our studies in Amish and Hutterite school children living on farms in the U.S. have further demonstrated that this protection is mediated through innate immune pathways. Although very similar with respect to ancestry and many lifestyle factors that are associated with asthma risk, Amish and Hutterites follow farming practices that are associated with profound differences in the levels of house dust endotoxin, in the prevalence of asthma and atopy among school children, and in the proportions, phenotypes, and functions of immune cells from these children. In this review, we will consider our studies in Amish and Hutterites children in the context of the many previous studies in European farm children and discuss how these studies have advanced our understanding of the asthma-protective “farm effect”.

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Environmental and mucosal microbiota and their role in childhood asthma

Cited by 98 publications

References 46 publications

An approach to the asthma‐protective farm effect by geocoding: Good farms and better farms

An approach to the asthma‐protective farm effect by geocoding: Good farms and better farms

One Health Relationships Between Human, Animal, and Environmental Microbiomes: A Mini-Review

Immune development and environment: lessons from Amish and Hutterite children

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