Evaluation of the association between sensitization to common inhalant fungi and poor asthma control

Tanaka, Akihiko; Fujiwara, Akiko; Uchida, Yoshitaka; Yamaguchi, Munehiro; Ohta, Shin; Homma, Tetsuya; Watanabe, Yoshio; Yamamoto, Masayuki; Suzuki, Shintaro; Yokoe, Takuya; Sagara, Hironori

doi:10.1016/j.anai.2016.06.001

Cited by 27 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Participants with asthma seem to be particularly sensitized to Alternaria and Cladosporium, which is concordant with the literature [26,27]. Participants with As + AR had the highest rate of sensitization to cat and D. pteronyssinus, but also to all the allergens related to hay/pollen and Alternaria.…”

Section: Discussionsupporting

confidence: 88%

“…Participants with AR alone and As + AR were particularly sensitized to allergens related to hay/pollen which bring out the "hay fever" part of allergic rhinitis. Participants with asthma seem to be particularly sensitized to Alternaria and Cladosporium, which is concordant with the literature [26,27]. The 10 allergens tested were chosen for being the most common, but it is possible that participants are sensitized to other allergens such as dog or Dermatophagoides farinae [28], and then, considering these other allergens may increase the number of positive SPT.…”

Section: Discussionsupporting

confidence: 67%

See 1 more Smart Citation

The sensitization pattern differs according to rhinitis and asthma multimorbidity in adults: the EGEA study

Burte

Bousquet

Siroux

et al. 2017

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 67%

The sensitization pattern differs according to rhinitis and asthma multimorbidity in adults: the EGEA study

Burte

Bousquet

Siroux

et al. 2017

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…On the other hand, sensitization to house dust mites, pollen, Japanese cedar, furry animals or insects was not associated with poor asthma control in their study. 18 Another study done by Burbank AJ et al, found that tree and weed pollen sensitization was independent risk factor for poorly controlled asthma in African-American children. 19 Rhee H et al, found that pest allergies (cockroach and mouse) were associated with poorly controlled asthma.…”

Section: Discussionmentioning

confidence: 97%

A cross sectional study of patients with poorly controlled asthma at a referral centre

Rao

2019

Int J Adv Med

View full text Add to dashboard Cite

Background: Asthma is a common chronic disease of the airways. Poorly controlled asthma has significant impact on social and economic factors. This study was done to analyse the clinical profile of patients with poorly controlled asthma.Methods: This is an observational, cross sectional study. Total of 100 patients were evaluated. Data collected included symptomatology, assessment of asthma control by asthma control test scoring, spirometry, body mass index, co-morbidities and allergy testing report.Results: Among the 100 patients studied, 52% (n=52) were in the age group of 30 to 60 years. 48% (n=48) were males and 52% (n=52) were females. 76% (n=76) patients had adhered to treatment for bronchial asthma as advised which was in line with standard therapy. 86% (n=86) had co-existing illness. They included allergic rhinitis, obesity, GERD, anxiety, atopic dermatitis and chronic urticaria. 78% (n=78) of these cases were sensitized to indoor and outdoor allergens. 89% of sensitized cases were to house dust mite (n=70 of 78). This was followed by cockroach sensitization which was seen in 30.7% cases (n=24 of 78). Other allergens included pollens in 28.2% cases (n=22 of 78), aspergillus in 25.6% cases (n=20 of 78) and food allergens in 23% cases (n=18 of 78).Conclusions: Poorly controlled asthma cases require detailed evaluation of comorbid conditions and allergen sensitization profiles. Management of these conditions along with allergen control measures may benefit these patients along with step up of therapy.

show abstract

“…Chopra and colleagues showed that asthma patients with skin reactivity to the Aspergillus skin test (AST) had more cases of moderate and severe asthma versus nonreactive AST patients (98.6% vs. 3.2%, p < 0.001) in a cohort of 282 adult asthma patients over a 1-year period. Sensitization to Aspergillus has been found to have a more significant impact on asthma outcomes compared to other species of fungus [41,42]. For instance, Vincent et al [41] demonstrated that adult asthma patients who were sensitized to Penicillium chrysogenum, , p = 0.059) [41].…”

Section: Endotoxinmentioning

confidence: 99%

The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood

Howard

Orhurhu

Huang

et al. 2019

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

Purpose of Review Asthma is a chronic respiratory condition with increasing domestic and worldwide prevalence that burdens individuals and the healthcare system with high costs associated with long-term treatments and acute emergency room (ER) visits. It can be triggered by ambient microbes, including bacteria, viruses, and fungi. In this review, we examine the outcomes of asthma patients in relation to environmental exposures to ambient microbe products, focusing on whether exposure leads to asthma development from birth to childhood and if particular microbes are associated with worsened asthma exacerbations. Recent Findings Bacterial endotoxin is more prominent in homes with pets and may cause cytokine cascades that lead to asthma exacerbation. However, some studies have demonstrated a protective effect with early exposure. Patients with positive Aspergillus skin testing are more prone to moderate-severe or severe-uncontrolled asthma. Fungal sensitization is also associated with earlier onset of asthma and demonstrates a dose-dependent relationship of symptom severity and duration. Among viruses, rhinovirus has the greatest association with decreased lung function, severe asthma, and asthma-related hospital admissions. Distribution of microbial products and associated asthma symptoms depends on the geographical climate. Genetic variations among individuals also mitigate the effects of microbial products on asthma development and symptom severity. Summary Microbial products of bacteria, fungi, and viruses are associated with the development of asthma, more severe asthma symptoms, and worse outcomes. However, some early exposure studies have also demonstrated a protective effect. Bacterial and fungal products are related to decreased lung function and earlier onset of asthma. Viral products are related to asthma-associated hospital admissions; and the climate and patient genetics can also temper or intensify the relationships between microbial products, asthma development, and asthma symptom severity. Further research should focus on the effects of early microbe exposure and its interaction with human immune systems and asthma-related outcomes.

show abstract

Evaluation of the association between sensitization to common inhalant fungi and poor asthma control

Cited by 27 publications

References 28 publications

The sensitization pattern differs according to rhinitis and asthma multimorbidity in adults: the EGEA study

The sensitization pattern differs according to rhinitis and asthma multimorbidity in adults: the EGEA study

A cross sectional study of patients with poorly controlled asthma at a referral centre

The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood

Contact Info

Product

Resources

About