Peromyscus as a model system for human hepatitis C: An opportunity to advance our understanding of a complex host parasite system

Vandegrift, Kurt J.; Critchlow, Justin T.; Kapoor, Amit; Friedman, David Adam; Hudson, Peter J.

doi:10.1016/j.semcdb.2016.07.031

Cited by 5 publications

(7 citation statements)

References 131 publications

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“…They can be divided into two main groups: Animals expressing single antigens or the full viral genome and humanized animals (Section “Humanized animals”) ( Figure 2 C). Animals from the first group usually include those expressing HBsAg [ 103 ], HbcAg [ 104 ], HbeAg [ 105 ], HBx [ 106 ], HCV envelope genes [ 107 ], HCV core [ 108 ] or the full HBV or HCV viral genome [ 109 , 110 , 111 , 112 ].…”

Section: Various In Vivo Approaches In Hepatotropic Virus Modelingmentioning

confidence: 99%

“…They can be divided into two main groups: Animals expressing single antigens or the full viral genome and humanized animals (Section "Humanized animals") (Figure 2C). Animals from the first group usually include those expressing HBsAg [103], HbcAg [104], HbeAg [105], HBx [106], HCV envelope genes [107], HCV core [108] or the full HBV or HCV viral genome [109][110][111][112]. Although transgenic models (usually murine ones) carrying viral genes do not recapitulate several crucial stages of the virus pathogenesis (viral entry, nuclear import, and cccDNA formation), they ensure the virus replication and secretion of viral particles [2], and therefore, can contribute most to the studies on drugs influencing these particular stages.…”

Section: Transgenic Animalsmentioning

confidence: 99%

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Modeling Hepatotropic Viral Infections: Cells vs. Animals

Rad

Zahmatkesh

Bikmulina

et al. 2021

Cells

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The lack of an appropriate platform for a better understanding of the molecular basis of hepatitis viruses and the absence of reliable models to identify novel therapeutic agents for a targeted treatment are the two major obstacles for launching efficient clinical protocols in different types of viral hepatitis. Viruses are obligate intracellular parasites, and the development of model systems for efficient viral replication is necessary for basic and applied studies. Viral hepatitis is a major health issue and a leading cause of morbidity and mortality. Despite the extensive efforts that have been made on fundamental and translational research, traditional models are not effective in representing this viral infection in a laboratory. In this review, we discuss in vitro cell-based models and in vivo animal models, with their strengths and weaknesses. In addition, the most important findings that have been retrieved from each model are described.

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Section: Various In Vivo Approaches In Hepatotropic Virus Modelingmentioning

confidence: 99%

Section: Transgenic Animalsmentioning

confidence: 99%

Modeling Hepatotropic Viral Infections: Cells vs. Animals

Rad

Zahmatkesh

Bikmulina

et al. 2021

Cells

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“…Most research has been carried out in the chimpanzee (Pan troglodytes) model, with important limitations in terms of ethics, small sample sizes, high costs, and genetic heterogeneity (Mesalam et al, 2016), and in the horse model with similar limitations too (Ramsay et al, 2015). Recent models involving chimeric mice with humanized livers and rodent species such as the deer mouse (Peromyscus maniculatus) have improved the situation (Mesalam et al, 2016;Vandegrift et al, 2017). The deer mouse natural model is particularly attractive with the recent discovery of a HCV homolog in this species (Kapoor et al, 2013).…”

Section: Hepatitis C Virusmentioning

confidence: 99%

“…The deer mouse natural model is particularly attractive with the recent discovery of a HCV homolog in this species (Kapoor et al, 2013). These mice are available commercially, develop a spontaneous disease very similar to HCV hepatitis and can serve as natural model to inform about various aspects of this (Vandegrift et al, 2017). There is no pig model to study human HCV infection.…”

Section: Hepatitis C Virusmentioning

confidence: 99%

Contribution of the swine model in the study of human sexually transmitted infections

Käser

Renois

Wilson

et al. 2018

Infection, Genetics and Evolution

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The pig has garnered more and more interest as a model animal to study various conditions in humans. The growing success of the pig as an experimental animal model is explained by its similarities with humans in terms of anatomy, genetics, immunology, and physiology, by their manageable behavior and size, and by the general public acceptance of using pigs for experimental purposes. In addition, the immunological toolbox of pigs has grown substantially in the last decade. This development led to a boost in the use of pigs as a preclinical model for various human infections including sexually transmitted diseases (STIs) like Chlamydia trachomatis. In the current review, we discuss the use of animal models for biomedical research on the major human STIs. We summarize results obtained in the most common animal models and focus on the contributions of the pig model towards the understanding of pathogenesis and the host immune response. In addition, we present the main features of the porcine model that are particularly relevant for the study of pathogens affecting human female and male genital tracts. We also inform on the technological advancements in the porcine toolbox to facilitate new discoveries in this biologically important animal model. There is a continued need for improvements in animal modeling for biomedical research inclusive STI research. With all its advantages and the highly improved toolbox, the porcine model can play a crucial role in STI research and open the door to new exciting discoveries.

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“…A small animal model based on a naturally occurring virus-host interaction, as has been achieved recently for Norway rat hepacivirus in Norway rats [21], would allow more detailed pathogenesis studies. This would greatly facilitate further research in the development of vaccines [22,23] and novel antivirals [21,24].…”

Section: Introductionmentioning

confidence: 99%

The Bank Vole (Clethrionomys glareolus)—Small Animal Model for Hepacivirus Infection

Röhrs

Begeman

Straub

et al. 2021

Viruses

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Many people worldwide suffer from hepatitis C virus (HCV) infection, which is frequently persistent. The lack of efficient vaccines against HCV and the unavailability of or limited compliance with existing antiviral therapies is problematic for health care systems worldwide. Improved small animal models would support further hepacivirus research, including development of vaccines and novel antivirals. The recent discovery of several mammalian hepaciviruses may facilitate such research. In this study, we demonstrated that bank voles (Clethrionomys glareolus) were susceptible to bank vole-associated Hepacivirus F and Hepacivirus J strains, based on the detection of hepaciviral RNA in 52 of 55 experimentally inoculated voles. In contrast, interferon α/β receptor deficient C57/Bl6 mice were resistant to infection with both bank vole hepaciviruses (BvHVs). The highest viral genome loads in infected voles were detected in the liver, and viral RNA was visualized by in situ hybridization in hepatocytes, confirming a marked hepatotropism. Furthermore, liver lesions in infected voles resembled those of HCV infection in humans. In conclusion, infection with both BvHVs in their natural hosts shares striking similarities to HCV infection in humans and may represent promising small animal models for this important human disease.

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Peromyscus as a model system for human hepatitis C: An opportunity to advance our understanding of a complex host parasite system

Cited by 5 publications

References 131 publications

Modeling Hepatotropic Viral Infections: Cells vs. Animals

Modeling Hepatotropic Viral Infections: Cells vs. Animals

Contribution of the swine model in the study of human sexually transmitted infections

The Bank Vole (Clethrionomys glareolus)—Small Animal Model for Hepacivirus Infection

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