TiO₂ microspheres containing magnetic nanoparticles for intra‐arterial hyperthermia

Abstract

Magnetic microspheres measuring 15-35 µm in diameter are believed to be useful for intra-arterial hyperthermia. In this study, we attempted to prepare titanium dioxide (TiO ) microspheres containing magnetic nanoparticles (MNPs). MNP-containing TiO microspheres with diameters of approximately 30 µm were successfully obtained by sol-gel reaction of titanium tetraisopropoxide in a water-in-oil emulsion with added cosurfactant of 1-butanol and subsequent heat treatment at 200°C. The microspheres showed ferrimagnetism owing to high content of MNPs in approximately 60 wt % and had a low-crystalline TiO matrix. Furthermore, the agar phantom was heated to above 43°C after approximately 1 min under an alternating magnetic field of 100 kHz and 300 Oe and showed in vitro biocompatibility similar to that of MNP-free TiO microspheres. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2308-2314, 2017.

In vitro evaluation of doxorubicin-eluting porous titania microspheres for transcatheter arterial chemoembolization

“…All reagent-grade chemicals were purchased from Wako Pure Chemical Industries, Ltd. (Tokyo, Japan). Porous TiO 2 microspheres were prepared using a sol-gel method with a water-in-oil (W/O) emulsion, based on our previous studies [13,14]. The composition and stirring conditions of the oil phase were the same as those in our previous study [14].…”

“…Porous TiO 2 microspheres were prepared using a sol-gel method with a water-in-oil (W/O) emulsion, based on our previous studies [13,14]. The composition and stirring conditions of the oil phase were the same as those in our previous study [14]. The components and mixing conditions of the aqueous phase were also the same as those in our previous study [14], but the methanol content was reduced from 2.7 g to 1.7 g for this study.…”

“…The in vitro biocompatibility of the samples was evaluated using Rat fibroblast Rat-1 cells in a procedure similar to that in our previous studies [14,15]. Rat-1 cells were cultured in Dulbecco's modified Eagle's medium (DMEM; Wako Pure Chemical Industries Ltd.) with 10% horse serum (Thermo Fisher Scientific, K.K., Tokyo, Japan), 100 units•mL −1 penicillin (Meiji Seika Kaisha, Ltd., Tokyo, Japan), and 100 µg•mL −1 streptomycin (Meiji Seika Kaisha, Ltd.).…”

Development and evaluation of the properties of functional ceramic microspheres for biomedical applications

“…27) Furthermore, they had an SAR of 20.0 W·g ¹1 under an alternating magnetic field of 300 Oe and 100 kHz and showed in vitro biocompatibility similar to that of MNP-free TiO 2 microspheres. 27) Iron (¡-Fe)-containing TiO 2 microspheres were also proposed, although the content of ¡-Fe was still low (10.4 wt %) and the heat-generating ability required further improvement.…”

Vías de obtención de nanomateriales empleados para el tratamiento del cáncer por hipertermia magnética

“…Sol-gel Poli (óxido de etileno) (U-PEO) con nanopartículas superparamagnéticas (γ-Fe 2 O 3 ) (Caetano et al, 2016) Ferritas de Zn 0.50 Ca 0.50 Fe 2 O 4 (Jasso-Teran et al, 2017) Microesferas de TiO 2 que contienen nanopartículas magnéticas (Kanetaka et al, 2017) Coprecipitación química…”