Deteriorating Infrastructure in the Aged Muscle Stem Cell Niche

Abstract

Following an injury, the extracellular matrix (ECM) undergoes dramatic remodeling to facilitate tissue repair. In a new study, Lukjanenko and colleagues show how an age-associated change in this process affects the regenerative ability of muscle stem cells (MuSCs).

Hematopoietic Lineage Diversification, Simplified

“…Roy Drissen 1 and Claus Nerlov 1, * Hematopoiesis is a complex process that requires a high degree of transcriptional diversification during lineage commitment and differentiation. de Graaf et al (2016) have now generated a comprehensive gene expression dataset that allows cell-type-specific genes as well as associated transcription factor expression patterns to be readily identified.…”