Potential of surface-eroding poly(ethylene carbonate) for drug delivery to macrophages

Bohr, Adam; Water, Jorrit J.; Wang, Yingya; Arnfast, Lærke; Beck-Broichsitter, Moritz

doi:10.1016/j.ijpharm.2016.07.075

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…Preparation of polymer films. PEC films were fabricated by a solvent casting technique [20,21]. Therefore, PEC without or with added rifampicin (10 wt.% per polymer mass) were accurately weighed and then dissolved in chloroform at a concentration of 100 mg/ml.…”

Section: 7mentioning

confidence: 99%

Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate)

Bohr

Wang

Harmankaya

et al. 2017

European Journal of Pharmaceutics and Biopharmaceutics

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Poly(ethylene carbonate) (PEC) is a unique biomaterial showing significant potential for controlled drug delivery applications. The current study investigated the impact of the molecular weight on the biological performance of drug-loaded PEC films. Following the preparation and thorough physicochemical characterization of diverse PEC (molecular weights: 85, 110, 133, 174 and 196kDa), the degradation and drug release behavior of rifampicin- and bovine serum albumin-loaded PEC films was investigated in vitro (in the presence and absence of cholesterol esterase), in cell culture (RAW264.7 macrophages) and in vivo (subcutaneous implantation in rats). All investigated samples degraded by means of surface erosion (mass loss, but constant molecular weight), which was accompanied by a predictable, erosion-controlled drug release pattern. Accordingly, the obtained in vitro degradation half-lives correlated well with the observed in vitro half-times of drug delivery (R=0.96). Here, the PEC of the highest molecular weight resulted in the fastest degradation/drug release. When incubated with macrophages or implanted in animals, the degradation rate of PEC films superimposed the results of in vitro incubations with cholesterol esterase. Interestingly, SEM analysis indicated a distinct surface erosion process for enzyme-, macrophage- and in vivo-treated polymer films in a molecular weight-dependent manner. Overall, the molecular weight of surface-eroding PEC was identified as an essential parameter to control the spatial and temporal on-demand degradation and drug release from the employed delivery system.

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Section: 7mentioning

confidence: 99%

Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate)

Bohr

Wang

Harmankaya

et al. 2017

European Journal of Pharmaceutics and Biopharmaceutics

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“…The presence or absence of pores may be one of the features indicating the differences between bulk erosion and surface erosion. This was shown by Bohr and coworkers, who compared the morphological features during the degradation of poly(ethylene carbonate) and PLGA films loaded with rifampicin [67]. In this study, the P(L-LA:GA:TMC) should represent a mixed mechanism at the level of morphological features, i.e., L-LA and GA are responsible for bulk erosion, and TMC for surface erosion.…”

Section: Raw P(l-la:ga:tmc)mentioning

confidence: 62%

Development of the Latanoprost Solid Delivery System Based on Poly(l-lactide-co-glycolide-co-trimethylene carbonate) with Shape Memory for Glaucoma Treatment

et al. 2023

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Latanoprost (LTP) is a prostaglandin F2α analog used to lower intraocular pressure in glaucoma treatment administered daily as eye drops. In this study, a universal model based on poly(l-lactide-co-glycolide-co-trimethylene carbonate) with shape memory was proposed for the development of a solid biodegradable formulation with prolonged release administered intraconjunctivally, intravitreally, subconjunctivally, and subcutaneously. Solution casting and electron beam (EB) irradiation were applied to the matrix formulation. The properties of the native matrix and matrices degraded in a PBS buffer (pH 7.4) were monitored by NMR, DSC, GPC, and SEM. Water uptake (WU) and weight loss (WL) were also analyzed. LTP was released over 113 days in a tri-phasic and sigmoidal pattern without a burst effect and with a relatively long second release phase, in which changes were observed in the glass transition temperature, molecular weight (Mn), WU, and WL. EB irradiation decreased the initial Mn, increased WU, and accelerated LTP release with a shortened lag phase. This provides the opportunity to partially eliminate the use of drops at the start of treatment. SEM observations indicated that surface erosion is the prevalent degradation mechanism. The proposed model is an interesting solution during a preliminary study to develop final medicinal products that provide high adherence.

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“…And this work indicated that on-demand drug delivery induced by macrophages can be achieved with PEC-based drug delivery systems (Chu et al, 2014). As PEC has a short degradation period, typically completed within 2-4 weeks, it is difficult for PEC to be used in long-term drug delivery (Bohr et al, 2016). By embedding anti-oxidants into the PEC polymer matrix to scavenge the free radicals produced by phagocytes, Selvakumar et al (2016) had slowed down the degradation rate of PEC.…”

Section: Poly (Ethylene Carbonate)mentioning

confidence: 93%

“…As a well-studied fatty acid polycarbonate, poly (ethylene carbonate) (PEC) obtained by ROCP of ethylene oxide and CO 2 , shows unique surface erosion caused degradation both in vitro and in vivo. As a result, drug release behavior of PEC-based delivery systems usually is directly correlated with polymer mass loss, which would improve the predictability of the drug release profile these drug delivery systems (Bohr et al, 2016). On the other hand, PEC degradation could be triggered by some special enzymes and cells.…”

Section: Poly (Ethylene Carbonate)mentioning

confidence: 99%

Recent progress in nanocomposites of carbon dioxide fixation derived reproducible biomedical polymers

et al. 2022

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In recent years, the environmental problems accompanying the extensive application of biomedical polymer materials produced from fossil fuels have attracted more and more attentions. As many biomedical polymer products are disposable, their life cycle is relatively short. Most of the used or overdue biomedical polymer products need to be burned after destruction, which increases the emission of carbon dioxide (CO2). Developing biomedical products based on CO2 fixation derived polymers with reproducible sources, and gradually replacing their unsustainable fossil-based counterparts, will promote the recycling of CO2 in this field and do good to control the greenhouse effect. Unfortunately, most of the existing polymer materials from renewable raw materials have some property shortages, which make them unable to meet the gradually improved quality and property requirements of biomedical products. In order to overcome these shortages, much time and effort has been dedicated to applying nanotechnology in this field. The present paper reviews recent advances in nanocomposites of CO2 fixation derived reproducible polymers for biomedical applications, and several promising strategies for further research directions in this field are highlighted.

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Potential of surface-eroding poly(ethylene carbonate) for drug delivery to macrophages

Cited by 7 publications

References 33 publications

Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate)

Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate)

Development of the Latanoprost Solid Delivery System Based on Poly(l-lactide-co-glycolide-co-trimethylene carbonate) with Shape Memory for Glaucoma Treatment

Recent progress in nanocomposites of carbon dioxide fixation derived reproducible biomedical polymers

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