Remarkable In Vivo Nonlinear Photoacoustic Imaging Based on Near-Infrared Organic Dyes

Gao, Fei; Bai, Linyi; Feng, Xiaohua; Tham, Huijun Phoebe; Zhang, Ruochong; Zhang, Yuanyuan; Liu, Siyu; Zhao, Lingzhi; Zheng, Yuanjin; Zhao, Yanli

doi:10.1002/smll.201602121

Cited by 32 publications

(15 citation statements)

References 44 publications

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“…Nonlinear PA imaging involves continuous excitation of biological tissue by employing a dual‐pulse laser with a short time delay, which can provide even more significant contrast and resolution than the commonly studied linear PA imaging by reversibly switching the absorption property, or enhancing the thermally related Gruneisen parameter (thermal expansion coefficient) . Some preliminary work about the contrast agents for nonlinear PA imaging has been reported recently . For example, Gao et al designed a contrast agent including two NIR dyes of IR‐820 and IR‐825 for nonlinear PA imaging .…”

Section: Nonlinear Pa‐imaging Contrast Agentsmentioning

confidence: 99%

“…Some preliminary work about the contrast agents for nonlinear PA imaging has been reported recently . For example, Gao et al designed a contrast agent including two NIR dyes of IR‐820 and IR‐825 for nonlinear PA imaging . Zheng and co‐workers reported a contrast agent of zinc‐tetra(4‐pyridyl)‐porphyrin‐encapsulated AuNRs for both nonlinear and linear PA‐imaging contrast enhancement .…”

Section: Nonlinear Pa‐imaging Contrast Agentsmentioning

confidence: 99%

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Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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Photoacoustic (PA) imaging as a fast‐developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light‐absorption coefficient of the imaged tissue and the injected PA‐imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA‐imaging contrast agents are developed to improve the PA‐imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA‐imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA‐imaging contrast agents and their significance in biomedical research is presented.

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Section: Nonlinear Pa‐imaging Contrast Agentsmentioning

confidence: 99%

Section: Nonlinear Pa‐imaging Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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“…NIR nanoprobes usually have excellent optical absorption coefficient that can greatly improve the sensitivity of PA imaging, even when facing the challenge of the strong background interference. [ 19–22 ] Simultaneously, the combination of functional aptamer with nanoprobes further facilitates the achievement of non‐invasive diagnosis at molecule level. However, the application of non‐invasive PA imaging in AS disease is still in its infancy.…”

Section: Figurementioning

confidence: 99%

A Non‐Invasive Nanoprobe for In Vivo Photoacoustic Imaging of Vulnerable Atherosclerotic Plaque

Cui

Kong

et al. 2020

Advanced Materials

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Vulnerable atherosclerotic (AS) plaque is the major cause of cardiovascular death. However, clinical methods cannot directly identify the vulnerable AS plaque at molecule level. Herein, osteopontin antibody (OPN Ab) and NIR fluorescence molecules of ICG co‐assembled Ti3C2 nanosheets are reported as an advanced nanoprobe (OPN Ab/Ti3C2/ICG) with enhanced photoacoustic (PA) performance for direct and non‐invasive in vivo visual imaging of vulnerable AS plaque. The designed OPN Ab/Ti3C2/ICG nanoprobes successfully realize obvious NIR fluorescence imaging toward foam cells as well as the vulnerable AS plaque slices. After intravenous injection of OPN Ab/Ti3C2/ICG nanoprobes into AS model mice, in vivo imaging results show a significantly enhanced PA signal in the aortic arch accumulated with vulnerable plaque, well indicating the remarkable feasibility of OPN Ab/Ti3C2/ICG nanoprobes to distinguish the vulnerable AS plaque. The proposed OPN Ab/Ti3C2/ICG nanoprobes not only overcome the clinical difficulty to differentiate vulnerable plaque, but also achieve the non‐invasively specific in vivo imaging of vulnerable AS plaque at molecule level, greatly promoting the innovation of cardiovascular diagnosis technology.

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“… 28 , 29 To overcome these problems, a variety of organic photothermal agents have emerged, such as NIR dyes (ICG, IR-820, and IR-825) and RC-BSA. 30 – 32 However, the low PTC efficiencies of these organic materials are not satisfactory for clinical application. Hence, the rational design and synthesis of effective PTT agents with higher PTC efficiency is in urgent need.…”

Section: Introductionmentioning

confidence: 99%