Supplementation of vitamin B12 or folic acid on hemoglobin concentration in children 6–36 months of age: A randomized placebo controlled trial

Kumar, Tivendra; Taneja, Sunita; Sachdev, H. P. S.; Refsum, Helga; Yajnik, Chittaranjan S.; Bhandari, Nita; Strand, Tor A.

doi:10.1016/j.clnu.2016.07.002

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…The overall prevalence of anaemia was 41.6%, a clear demonstration that it's a common issue at the study area. This prevalence is higher as compared to that of WHO recommendations cut-off point of 11 g/dL in the same African children [41]. Our finding was similar to 2016 Ethiopian DHS prevalence reported for the Amhara Region (42%) [5] and study conducted in Jimma, Ethiopia (46%) [22].…”

Section: Discussionsupporting

confidence: 83%

Morphological patterns of anemia among under five children on Prevention of Mother-To-Child Transmission (PMTCT) programmes in Masogo sub-county hospital, Kisumu county, Kenya

Awuor¹,

Eric²,

Musyoki³

et al. 2021

J Clin Images Med Case Rep

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Background: Anaemia during childhood adversely affects mental, physical and social development of the children, therefore morphological patterns of anaemia in under- five children are considered essential for classification, diagnosis and management. Aim: This study aimed at assessing morphological patterns, the prevalence and associated factors of anaemia among under-five children on Prevention of Mother-To-Child Transmission (PMTCT) programmes in Masogo sub-county hospital, Kisumu County, Kenya. Method: A cross-sectional health facility-based study was conducted among 175 children aged 6 to 59 months who attended clinic for the PMTCT programme for the period of January 2020 to December 2020. Pretested and structured questionnaires were used to collect socioeconomic and demographic characteristics of the family and child. Capillary blood sample was collected from each child for malaria parasite and Peripheral Blood Film (PBF) examination. Result: Complete blood counts indicate that microcytic pattern was the most common, representing 30 (42.3%) followed by microcytic hypochromic pattern 20 (28.2%), normocytic normochromic pattern with 11 (15.5%) and lastly dimorphic pattern with 10 (14.0%). High prevalence of anaemia was observed in children who were urban dwellers (50.0%), in children whose mothers aged 18-27 years (44.0%) and had no formal education (48.1%). Besides, the high prevalence rate of anaemia was found among children with a family monthly income of less than 500 Ksh. (46.9%), early (<6 months) introduction of complementary foods (71.4%). Conclusion: This study has revealed that the prevalence of anaemia in children less than five years is high and is a severe public health problem in the study area. Therefore, the policymakers should make a strategy that can reduce poverty and increase the awareness to women on breastfeeding, nutrition, and other associated factors to reduce anaemia.

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Section: Discussionsupporting

confidence: 83%

Morphological patterns of anemia among under five children on Prevention of Mother-To-Child Transmission (PMTCT) programmes in Masogo sub-county hospital, Kisumu county, Kenya

Awuor¹,

Eric²,

Musyoki³

et al. 2021

J Clin Images Med Case Rep

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“…Because 42% to 50% of anemia in children is expected to be caused by iron deficiency 4 [34], the prevalence of anemia in Rwanda would be overestimated in about two thirds of the children by using the WHO 11 gr/dL cutoff. In addition, use of the WHO 11 gr/dL cutoff criterion could explain why 88% of 6 to 30 months old anemic children from north India who received iron for two months remained anemic even after correction for iron deficiency [39].…”

Section: Anemia Rates By Who P5mentioning

confidence: 99%

Age and altitude of residence determine anemia prevalence in Peruvian 6 to 35 months old children

Accinelli

León-Abarca

2020

PLoS ONE

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Background A Demographic and Family Health Survey (ENDES, for Encuesta Demográ fica y de Salud Familiar in Spanish) is carried out annually in Peru. Based on it, the anemia prevalence was 43.6% in 2016 and 43.8% in 2017 using the WHO cutoff value of 11 g/dL and the altitudecorrection equation. Objective To assess factors contributing to anemia and to determine its prevalence in Peruvian children 6 to 35 months old. Methods We used the MEASURE DHS-based ENDES survey to obtain representative data for11364 children from 6 to 35 months old on hemoglobin and health determinants. To evaluate normal hemoglobin levels, we used the original WHO criterion of the 5 th percentile in children without chronic malnutrition and then applied it to the overall population. Relationships between hemoglobin and altitude levels, usage of cleaning methods to sanitize water safe to drink, usage of solid fuels and poverty status were tested using methodology for complex survey data. Percentile curves were made for altitude intervals by plotting hemoglobin compared to age. The new anemia rates are presented in graphs by Peruvian political regions according to the degree of public health significance. Results Hemoglobin increased as age and altitude of residence increased. Using the 5 th percentile, anemia prevalence was 7.3% in 2016 and 2017. Children from low altitudes had higher anemia prevalence (8.5%) than those from high altitudes (1.2%, p<0.0001). In the rainforest area of Peru, anemia prevalence was highest (13.5%), while in the highlands it was lowest

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“…Several studies have confirmed the relationship between vitamin B 12 concentration and Hb, MCV, MCH and Hct [42][43][44][45]. However, the majority of studies [46][47][48][49], as well as the recent meta-analysis [50], failed to prove such a relationship.…”

Section: Discussionmentioning

confidence: 97%

Vitamin B12 Status and Optimal Range for Hemoglobin Formation in Elite Athletes

et al. 2020

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Background: Athletes and coaches believe in the ergogenic effect of vitamin B12 (which results from enhanced erythropoiesis) and they often insist on its unjustified supplementation. Therefore, our study aimed to assess the vitamin B12 status in Polish elite athletes and its influence on red blood cell parameters. Methods: In total, 1131 blood samples were collected during six years from 243 track and field athletes divided into strength and endurance groups, as well as according to the declared use of vitamin B12 injections. Results: An average vitamin B12 concentration in all subjects was 739 ± 13 pg/mL, with no cases of deficiency. A weak but significant relationship was found between vitamin B12 and hemoglobin concentrations. A significant increase in hemoglobin appeared from very low vitamin B12 concentration and up to approx. 400 pg/mL, while hemoglobin did not significantly change from 700 pg/mL and onwards. Vitamin B12 injections were used by 34% of athletes, significantly more often by endurance than by strength athletes. In athletes who declared no use of injections, a higher concentration of vitamin B12 was observed in the endurance group. Conclusion: The main finding of the present study is the determination of the range of vitamin B12 concentration which may favor better hemoglobin synthesis in athletes. They should regularly monitor vitamin B12 concentration and maintain the range of 400–700 pg/mL as it may improve red blood cell parameters. We might suggest application of a supplementation if necessary. Special attention is required in athletes with a vitamin B12 concentration below 400 pg/mL.

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Supplementation of vitamin B12 or folic acid on hemoglobin concentration in children 6–36 months of age: A randomized placebo controlled trial

Cited by 9 publications

References 21 publications

Morphological patterns of anemia among under five children on Prevention of Mother-To-Child Transmission (PMTCT) programmes in Masogo sub-county hospital, Kisumu county, Kenya

Morphological patterns of anemia among under five children on Prevention of Mother-To-Child Transmission (PMTCT) programmes in Masogo sub-county hospital, Kisumu county, Kenya

Age and altitude of residence determine anemia prevalence in Peruvian 6 to 35 months old children

Vitamin B12 Status and Optimal Range for Hemoglobin Formation in Elite Athletes

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