Safety in the use of vaseline during oxygen therapy: the pharmacist’s perspective

Bauters, Tieneke; Schandevyl, Guy Van; Laureys, Geneviève

doi:10.1007/s11096-016-0365-7

Cited by 9 publications

(9 citation statements)

References 6 publications

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“…Concerning the use of petrolatum, the existing evidence in the evaluation of results shows some improvement in the protection of the skin as a barrier in adults hospitalized in Nursing homes in the reduction of skin tears (associated with friction and friction) 29 and dryness in older patients who do not mobilize 11,30,31 . This product has shown some difference (low evidence) in preventing superficial pressure ulcers but not in the appearance of more complex ulcers (Grade II or IV) 31 , which hypothetically form from deep subcutaneous tissues, as hypothesized in other studies 16 .…”

Section: Discussionmentioning

confidence: 99%

Impact of hydrocolloid dressings in the prevention of pressure ulcers in high-risk patients: a randomized controlled trial (PENFUP)

Cortés,

Herrera,

Salazar

et al. 2023

Sci Rep

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It is uncertain whether hydrocolloid dressings, a more costly intervention than offering standard care with petrolatum, is superior to prevent pressure ulcers among hospitalized high-risk adults. Randomized, parallel-group, open-label, superiority trial with an active control group, blinded for investigators, event validators, and analysts (December 1, 2015 to December 12, 2017). Eligible patients were ≥ 18 years of age with intact skin judged as high-risk for skin ulcers (Braden scale), admitted to surgical or medical wards of two tertiary-level hospitals. Participants were randomized (1:1) to protection with hydrocolloid dressings or petrolatum. The primary outcome was the first occurrence of pressure ulcers (with post-injury photographs adjudicated by three judges) under intention-to-treat analysis. Based on prior cost analysis, and the available resources (assumed incidence of 6 ulcers/1000 patient-days in controls), inclusion of up to 1500 participants allowed to surpass a one-sided superiority threshold > 5% based on a target efficacy > 40% for dressings. We planned an economic analysis using a decision tree model based on the effectiveness of the study results from a perspective of the third payer of health care. After inclusion of 689 patients (69 events), the trial was stopped for futility after a planned interim analysis (conditional power < 0.1 for all scenarios if the trial was completed). Pressure ulcers had occurred in 34 (10.2%) patients in the intervention group [9.6 per 1000 patient-days] and 35 (9.9%) participants in the control group [7.9 per 1000 patient-days], HR = 1.07 [95% CI 0.67 to 1.71]. The estimated incremental cost for dressings (a dominated strategy) was USD 52.11 per patient. Using hydrocolloid dressings was found similar to petrolatum for preventing pressure ulcers among hospitalized high-risk patients. As it conveys additional costs, and in this study was unlikely to demonstrate enough superiority, this strategy did not overcome conventional skin care.Trial registration: ClinicalTrials.gov identifier (NCT number): NCT02565745 registered on December 1, 2015.

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Section: Discussionmentioning

confidence: 99%

Impact of hydrocolloid dressings in the prevention of pressure ulcers in high-risk patients: a randomized controlled trial (PENFUP)

Cortés,

Herrera,

Salazar

et al. 2023

Sci Rep

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“…The adverse effect of vaseline album is rare when used as topical preparation. 24 A previous study showed that application of vaseline album can heal exfoliative and dry lips of patients with vitamin D deficiency. 25 In our study, the patient was cooperative with positive attitude during the treatment.…”

Section: Discussionmentioning

confidence: 99%

Uremic stomatitis mimicking oral squamous cell carcinoma associated with local and systemic factor

Ridho,

Hasanah,

Dewi

2023

Majalah Kedokteran Gigi Indonesia

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Uremic stomatitis is one of the oral manifestations of chronic kidney disease. This disease is caused due to increased levels of urea in the blood circulation. Patients will complain sore lesions accompanied by a characteristic ammonia breath odor. The clinical manifestation of uremic stomatitis is not only influenced by high levels of urea in the blood but also related to local factors, the oral anatomy and parafunction habits. This study aimed to present a case report of clinical features of uremic stomatitis that mimicking oral squamous cell carcinoma. A 51 year old woman was referred from the department of internal medicine to the department of oral medicine at Hasan Sadikin Hospital, Bandung. The patient complained of pain in the tongue and also when swallowing. The clinical manifestation shows an ulcerated lesion on the right lateral of the tongue and a slightly raised hyperkeratotic area on the floor of the mouth. The treatment is using 0.12% chlorhexidine digluconate mouthwash three times a day and followed by applying a thin layer of vaseline on the upper and lower lips, as well as instructions and education on maintaining oral and tongue hygiene. Controls were carried out on the second and fourteenth day. The patient complaints are decreasing until disappear. The patient's masticatory function is getting better. Local and systemic factors have effect on the clinical manifestation of uremic stomatitis. A clinician must be able to carry out examinations, establish diagnosis and appropriate management so that patients receive appropriate treatment.

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Section: Discussionmentioning

confidence: 99%

“…This shows the potential of the pharmacist in facilitating the Nursing work when there are doubts about dilution, infusion and drug compatibility, in addition to assisting the medical team in decisions involving pharmacotherapy. 5,24,25 Inadequate doses (overdoses or underdoses) were also frequently found in DRPs. They especially included situations of antimicrobial and immunosuppressive overdoses in individuals with kidney or liver failure, difficulties related to the serum level of the immunosuppressives, overdose of the proton pump inhibitors, inadequate introduction of prophylactic antiepileptics (without or inadequate dose escalation), and off-label use in pediatric patients.…”

Section: Discussionmentioning

confidence: 99%

Impact of the insertion of the clinical pharmacist in the Allogeneic Hematopoietic Stem Cells Transplantation team

Zanetti

Rodrigues

Varallo

et al. 2022

J Oncol Pharm Pract

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Introduction Allogeneic Hematopoietic Stem Cells Transplantation (allo-HSCT) is capable of curing patients with neoplastic or non-neoplastic hematologic disorders or of prolonging their survival. This study assessed if the insertion of the clinical pharmacist in the allo-HSCT team modified the outcomes: transplantation-related mortality, grafting failure, incidence of Graft versus Host Disease, hospitalization time, time for grafting, number of readmissions, number of drug-related problems (DRPs), adherence and knowledge about pharmacotherapy. Methods: Interventional study with historical control carried out in an allo-HSCT unit, in which the intervention group (IG) included 33 individuals who received pharmacotherapy follow-up. Control Group (CG) consisted of 28 individuals. Results: A total of 250 DRPs were identified, 59 team's doubts were clarified, and 309 interventions were conducted in the IG. The DRPs mainly arose from safety (51.60%) and effectiveness (38.40%) problems. A mean of 9.36 (SD = 6.97) interventions per patient was obtained, mainly including dose reductions (19.09%), adjustments in administration time (18.12%), educational activities (15.21%) and drug removal (10.68%). Clinical significance of the interventions was considered high (75.7% extremely significant, very significant or significant), as well as their acceptability (89.7% accepted). Each patient attended a mean of 4.68 pharmaceutical consultations (SD = 1.91) after hospital discharge, presenting increase in knowledge (p = 0.0001) and in adherence (p = 0.0115). There was no evidence of differences between the groups in the other outcomes analyzed. Conclusions: The pharmacotherapy follow-up allowed detecting several DRPs and performing interventions of high clinical relevance and acceptability, in addition to improving adherence and individualizing the pharmacotherapy.

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Safety in the use of vaseline during oxygen therapy: the pharmacist’s perspective

Cited by 9 publications

References 6 publications

Impact of hydrocolloid dressings in the prevention of pressure ulcers in high-risk patients: a randomized controlled trial (PENFUP)

Impact of hydrocolloid dressings in the prevention of pressure ulcers in high-risk patients: a randomized controlled trial (PENFUP)

Uremic stomatitis mimicking oral squamous cell carcinoma associated with local and systemic factor

Impact of the insertion of the clinical pharmacist in the Allogeneic Hematopoietic Stem Cells Transplantation team

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