Associations between microvascular function and short-term exposure to traffic-related air pollution and particulate matter oxidative potential

Zhang, Xian; Staimer, Norbert; Tjoa, Tomas; Gillen, Daniel L.; Schauer, James J.; Shafer, Martin M.; Hasheminassab, Sina; Pakbin, Payam; Longhurst, John C.; Sioutas, Constantinos; Delfino, Ralph J.

doi:10.1186/s12940-016-0157-5

Cited by 65 publications

(43 citation statements)

References 57 publications

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“…Transition metals (eg, V, Fe, Co, Ni, Cu, Zn) from various sources have been associated with ROS generation, oxidative stress, and inflammation both in vitro and in human studies, [54][55][56]75,76 among other effects. Their redox activity is thought to stimulate cellular ROS production, eventually leading to oxidative stress and inflammation.…”

Section: Pahs and Trace Elementsmentioning

confidence: 99%

Impacts of stove/fuel use and outdoor air pollution on chemical composition of household particulate matter

et al. 2020

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Biomass combustion for cooking and heating releases particulate matter (PM2.5) that contributes to household air pollution. Fuel and stove types affect the chemical composition of household PM, as does infiltration of outdoor PM. Characterization of these impacts can inform future exposure assessments and epidemiologic studies, but is currently limited. In this study, we measured chemical components of PM2.5 (water‐soluble organic matter [WSOM], ions, black carbon, elements, organic tracers) in rural Chinese households using traditional biomass stoves, semi‐gasifier stoves with pelletized biomass, and/or non‐biomass stoves. We distinguished households using one stove type (traditional, semi‐gasifier, or LPG/electric) from those using multiple stoves/fuels. WSOM concentrations were higher in households using only semi‐gasifier or traditional stoves (31%‐33%) than in those with exclusive LPG/electric stove (13%) or mixed stove use (12%‐22%). Inorganic ions comprised 14% of PM in exclusive LPG/electric households, compared to 1%‐5% of PM in households using biomass. Total PAH content was much higher in households that used traditional stoves (0.8‐2.8 mg/g PM) compared to those that did not (0.1‐0.3 mg/g PM). Source apportionment revealed that biomass burning comprised 27%‐84% of PM2.5 in households using biomass. In all samples, identified outdoor sources (vehicles, dust, coal combustion, secondary aerosol) contributed 10%‐20% of household PM2.5.

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Section: Pahs and Trace Elementsmentioning

confidence: 99%

Impacts of stove/fuel use and outdoor air pollution on chemical composition of household particulate matter

et al. 2020

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“…Inverse associations have been observed between RHI and important risk factors for CVD, such as diabetes, obesity, smoking, and the ratio between total and HDL cholesterol (Hamburg et al 2008). Associations with PM exposures have been somewhat inconclusive: Decreased RHI was associated with increased air pollution exposure in elderly (Bräuner et al 2008a;Zhang et al 2016), but not in younger people (Bräuner et al 2008b;Li et al 2015;Ljungman et al 2014). Exposures to ambient air pollution mixtures showed associations with BPA, but not with hyperemic response to ischemia (Ljungman et al 2016).…”

Section: Rhi Vs Bpamentioning

confidence: 99%

Reactive hyperemia and baseline pulse amplitude among smelter workers exposed to fine and ultrafine particles

Bugge

Ulvestad

Berlinger

et al. 2019

Int Arch Occup Environ Health

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Objective Ambient exposure to fine particles is associated with increased cardiovascular morbidity and mortality. Associations between occupational particulate matter (PM) exposure and cardiovascular disease have been studied less. The objective of this study was to examine associations between PM exposure and endothelial function among workers in Norwegian smelters. Methods We examined endothelial function with Endo-PAT equipment after a working day (WD) and on a day off (DO) in 59 furnace workers recruited from three metal smelters in Norway. The difference in baseline pulse amplitude (BPA) and reactive hyperemia index (RHI) between the 2 days was analysed in relation to individual exposure to PM < 250 nm (PM 250) or the respirable aerosol fraction of particles, and adjusted for relevant covariates. Results The exposure to PM 250 ranged from 0.004 to 5.7 mg/m 3. The mean BPA was significantly higher on WD relative to DO (772 vs. 535, p = 0.001). This difference was associated with PM concentrations among participants ≥ 34 years, but not among the younger workers. Reactive hyperemia was significantly lower on workdays relative to days off (1.70 vs. 1.84, p = 0.05). This difference was observed only among participants above the age 34. No associations with PM exposure were observed. Conclusions PM exposure was associated with higher BPA among participants older than 34 years. BPA reflects microvessel pulsatility. Our results may indicate an age-dependent cardiovascular susceptibility to PM exposure. Endothelial function measured by RHI was reduced on WD among participants 34 years and older, but we found no associations between PM exposure and RHI.

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“…Previous studies have revealed that different size ranges of PM can be emitted from various sources with different fingerprints [10,11]. PM from different sources might have different toxicological characteristics as well as different impacts on visibility, and radiative forcing, supporting the postulation that PM mass concentration is not the most appropriate metric to investigate the adverse effects of PM [12,13]. Therefore, source apportionment studies are quite beneficial in identifying different sources of PM, their corresponding chemical compositions and their link with toxicity, which can further be used by health authorities to develop policies to mitigate the detrimental health impacts of exposure to ambient PM.…”

Section: Introductionmentioning

confidence: 99%

Sources and Temporal Variations of Coarse Particulate Matter (PM) in Central Tehran, Iran

et al. 2019

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In this study, we used the positive matrix factorization (PMF) model to evaluate the sources of ambient coarse particulate matter (PM) and their temporal variations in two sampling sites, i.e., a school dormitory and a retirement home, located in central Tehran. 24-h ambient PM samples were collected using low-volume air samplers from May 2012 to June 2013. The collected filters were analyzed for their chemical components, including water-soluble ions, metals, and trace elements, which were used as the input to the PMF model. Our results indicated annual averages of 45.7 ± 3.8 µg/m 3 and 36.2. ± 4.0 µg/m 3 for coarse PM at the School dormitory and Tohid retirement home, respectively. Moreover, higher ambient coarse PM mass concentrations were observed in the warm season (53.3 ± 5.8 µg/m 3 for school dormitory and 43.1 ± 6.1 µg/m 3 for Tohid retirement home) as opposed to the cold season (41.4 ± 4.7 µg/m 3 for school dormitory and 28.7 ± 4.6 µg/m 3 for Tohid retirement home). Our PMF analysis also identified road dust, soil, and industry, and atmospherically processed coarse PM as the three sources of ambient coarse PM in central Tehran. Road dust, soil, and industry were the major sources of ambient coarse PM, contributing respectively to 74 ± 9% and 19 ± 2% of the total coarse PM mass concentration, while atmospherically aged aerosols had a rather minimal contribution of 7 ± 1% to total coarse PM mass concentration. The temporal trends of the resolved factors also revealed higher contributions of road dust to total ambient coarse PM during warm season as opposed to cold season, due to the increased resuspension rate from road surfaces as a result of higher wind speeds, and temperatures, combined with lower relative humidity. Similarly, higher resuspension rate of mechanically originated particulates resulted in higher warm-season time contributions of the soil factor. Results of this study clearly revealed the key role of road dust and non-tail pipe emissions on ambient coarse PM mass concentrations in crowded areas of central Tehran, and have important implications on the potential health impacts that can be caused by these difficult to mitigate sources of coarse PM.

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Associations between microvascular function and short-term exposure to traffic-related air pollution and particulate matter oxidative potential

Cited by 65 publications

References 57 publications

Impacts of stove/fuel use and outdoor air pollution on chemical composition of household particulate matter

Impacts of stove/fuel use and outdoor air pollution on chemical composition of household particulate matter

Reactive hyperemia and baseline pulse amplitude among smelter workers exposed to fine and ultrafine particles

Sources and Temporal Variations of Coarse Particulate Matter (PM) in Central Tehran, Iran

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