Colorectal Cancer Epidemiology in the Nurses’ Health Study

Lee, Dong Hoon; Keum, NaNa; Giovannucci, Edward

doi:10.2105/ajph.2016.303320

Cited by 46 publications

(27 citation statements)

References 40 publications

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“…12 Although the studies mentioned above did not examine the incidence of CRC, their findings suggested that changes in neighborhood conditions may be related to important risk factors for CRC, such as obesity, cardiometabolic health, and diet. 27 Contrary to our original hypothesis, we observed that an increase in neighborhood SES was not associated with a lower risk of CRC. One possible explanation is that, for the participants in our study, the subsequent improvements in neighborhood conditions may have been modest, and the associated benefits may have been relatively small.…”

Section: Discussioncontrasting

confidence: 99%

“…Moreover, Zhang et al reported that loss of neighborhood supermarkets was related to worsening glycemic control after examining the data from the Kaiser Permanente Northern California Diabetes Registry . Although the studies mentioned above did not examine the incidence of CRC, their findings suggested that changes in neighborhood conditions may be related to important risk factors for CRC, such as obesity, cardiometabolic health, and diet …”

Section: Discussionmentioning

confidence: 99%

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Ten‐year change in neighborhood socioeconomic status and colorectal cancer

Zhang

Matthews

Powell‐Wiley

et al. 2018

Cancer

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Background A growing body of research has demonstrated that individuals who live in neighborhoods with more severe socioeconomic deprivation may have higher risks for colorectal cancer (CRC). However, previous studies have examined neighborhood socioeconomic status (SES) at only 1 point in time, and it is unclear whether changes in neighborhood SES also can influence the risks of CRC. Methods Cox regression analysis was used to examine different trajectories of change in neighborhood SES over 10 years in relation to the incidence of CRC among 266,804 participants (ages 51‐70 years) in the National Institutes of Health‐AARP Diet and Health Study. Eligible participants reported living in the same neighborhood at baseline (1995‐1996) and from 2004 to 2006 according to a follow‐up questionnaire. Changes in neighborhood SES were measured between 1990 and 2000 by SES indices derived from Census data. Neighborhoods were grouped into 4 categories based on median SES indices in 1990 and 2000 (low‐low, low‐high, high‐low, and high‐high). Results Compared with residents whose neighborhoods were in the higher SES group at both time points (reference category), those whose neighborhoods were consistently in the low SES group had a 7% higher risk of developing CRC (hazard ratio, 1.07; 95% confidence interval, 1.00‐1.14). Moreover, the risk of CRC was 15% higher (hazard ratio, 1.15; 95% confidence interval, 1.02‐1.28) for those living in neighborhoods with decreasing SES (high‐low) over time. Conclusions The current findings suggest that exposure to consistently low SES neighborhoods and/or a decrease in neighborhood SES over a period of time may be associated with higher risks of CRC.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ten‐year change in neighborhood socioeconomic status and colorectal cancer

Zhang

Matthews

Powell‐Wiley

et al. 2018

Cancer

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“…In 2012, it was estimated that 1,360,602 million new cases (women, 614,304; men, 746,298) of CRC were diagnosed (3). The burden of CRC worldwide is expected to increase by 60% to >2.2 million new cases and 1.1 million CRC-associated mortalities by 2030 (4).…”

Section: Introductionmentioning

confidence: 99%

The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery

Cao

2017

Oncology Letters

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The present study aimed to examine the association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery. The present study included 484 patients with colon cancer that underwent colon resection between December 2003 and December 2011. All follow-ups were censored in December 2013 with a median follow-up time of 43 months. Kaplan-Meier survival curves and Cox regression analysis were used to determine predictors for overall survival rate. p53 expression status (positive or negative) was significantly different between patient groups when categorized by age distribution, disease course, tumor location, maximum tumor diameter, depth of tumor invasion, Dukes' stage, distant metastasis and lymph node (LN) metastasis (P<0.05). Cox regression analysis revealed that age, surgery type, histological subtypes, tumor size, tumor location, LN metastasis, distant metastases, Dukes' stage and p53 expression status are independent factors influencing the survival rate of patients with colon cancer following surgery (P<0.05). Therefore, the present study revealed that the loss of p53 expression levels in tumors was associated with aggressive clinicopathological characteristics in patients with colon cancer.

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“…according to the Global Burden of Disease (GbD), in 2015, crc caused a loss of approximately 54.2 years of life per 10,000 inhabitants of eu-28, while in Poland, it was 66.2 years per 10,000. the highest number of ylls due to this cause were noted in Hungary -97.8 years per 10,000, in croatia -85.9 years per 10,000, and in slovakia -73.4 years per 10,000 [22]. the recognized risk factors for crc include: a diet rich in red meat and highly processed food, heat treatment of meat by its frying or grilling, obesity, excessive consumption of alcohol, cigarette smoking, sedentary lifestyle [23][24][25]. However, the causes of this unfavorable phenomena in the field of prematurely lost years of life due to crc can be seen in the deterioration of the health attitudes of Poles and the gradual acceptance of a so-called "western lifestyle" [26][27][28].…”

Section: Resultsmentioning

confidence: 99%

Years of life lost due to colorectal cancer in Poland between 2000 and 2014 according to voivodships

Paciej-Gołębiowska¹,

Pikala²,

Maniecka-Bryła³

2018

fmpcr

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Background. colorectal cancers (crcs) are among the most important oncological causes of death in europe. Poland belongs to countries where the mortality rates due to this cause exceed the average values for eu-28. Objectives. comparison of the number of years of life lost (ylls) due to crc between 2000 and 2014 in Poland by voivodships. Material and methods. the study was based on a dataset containing information from the death certificates of Poles who died in 2000 and 2014 (368,028 and 376,467 records, respectively). the data on deaths caused by crc (c18-c21 according to icD-10) was used for the analysis (8,517 deaths in 2000 and 11,411 deaths in 2014). seyll (standard expected years of life lost) was implemented to assess ylls. Results. in 2000, the highest number of ylls per 10,000 men was recorded in zachodniopomorskie (55.7 years), and in 2014-in opolskie (77.5 years). the increasing tendency of this measure between 2000 and 2014 in the group of men was observed in all voivodships. in the group of women, in 2000 the highest number of ylls per 10,000 was reported in lodzkie (46 years), and in 2014-in warminsko-Mazurskie (49.6 years). in women, an seyll p decline over time was noted only in lodzkie and Dolnoslaskie, and in other voivodships, its values increased. Conclusions. between 2000 and 2014, an upward tendency of ylls due to crc was observed in Poland, though with territorial differentiation. it is advisable to search for more effective methods of reducing existing inequalities between individual provinces of Poland.

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Colorectal Cancer Epidemiology in the Nurses’ Health Study

Abstract: The NHS has provided new insights into colorectal adenomas, CRC etiology, and pathogenic mechanisms. With its unique strengths, the NHS should continue to contribute to the field of CRC epidemiology and play a major role in public health.

Cited by 46 publications

References 40 publications

Ten‐year change in neighborhood socioeconomic status and colorectal cancer

Ten‐year change in neighborhood socioeconomic status and colorectal cancer

The association of p53 expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery

Years of life lost due to colorectal cancer in Poland between 2000 and 2014 according to voivodships

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