Corrigendum: Distinct Transcriptomic Features Are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen

Kleiman, Eden; Salyakina, Daria; Heusch, Magali de; Hoek, Kristen L.; Llanes, Joan M.; Castro, Iris; Wright, Jacqueline A.; Clark, Emily; Dykxhoorn, Derek M.; Capobianco, Enrico; Takeda, Akihiro; McCormack, Ryan; Podack, Eckhard R.; Renauld, Jean‐Christophe; Khan, Wasif N.

doi:10.3389/fimmu.2016.00267

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CD73, which is the rate-limiting enzyme for the production of ADO, plays a key role in the control of inflammatory signals [ 9 ]. A functional role for CD73 in regulating immune response is known in the tumor microenvironment, where it contributes to the reduction of anti-tumor immune responses [ 24 ]. Further support for the pathophysiological role of CD73 is shown in our previous works with chronic viral infections such as HIV infection, where CD73 deficiency of CD8 + T cells was associated with chronic immune activation [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes

Ahmadi

Hartjen

Kohsar

et al. 2020

Cells

View full text Add to dashboard Cite

The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the pathophysiology of COVID-19. Here, we analyzed CD39 and CD73 on different lymphocyte populations in a small cohort of COVID-19 patients and in healthy individuals. We describe a significantly lower level of expression of CD73 on cytotoxic lymphocyte populations, including CD8+ T, natural killer T (NKT), and natural killer (NK) cells, during COVID-19. Interestingly, the decrease of CD73 on CD8+ T cells and NKT cells correlated with serum ferritin levels. Furthermore, we observed distinct functional differences between the CD73+ and CD73- subsets of CD8+ T cells and NKT cells with regard to cytokine/toxin secretion. In COVID-19 patients, the majority of the CD73-CD8+ T cells were capable of secreting granzyme B, perforin, tumor necrosis factor (TNF-α) or interferon-gamma (IFN-γ). To conclude, in this first study of CD39 and CD73 expression of lymphocytes in COVID-19, we show that CD8+ T cells and NKT cells lacking CD73 possess a significantly higher cytotoxic effector functionality compared to their CD73+ counterparts. Future studies should investigate differences of cellular CD39 and CD73 expression in patients at different disease stages and their potential as prognostic markers or targets for immunomodulatory therapies.

show abstract

Section: Discussionmentioning

confidence: 99%