Environment and cardiovascular disease: rationale of the Corinthia study

Oikonomou, Evangelos; Lazaros, George; Georgiopoulos, G; Christoforatou, Evangelia; Papamikroulis, George-Angelo; Vogiatzi, Georgia; Chasikidis, Christos; Zacharia, Effimia; Giannaki, Anastasia; Bourouki, Evgenia; Mavratzas, Timoleon; Stofa, E; Papakonstantinou, M; Tousouli, Maria; Tousoulis, Dimitris

doi:10.1016/j.hjc.2016.06.001

Cited by 30 publications

(12 citation statements)

References 10 publications

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“…Combined, the HHS Hazelinks [ 15 ], Early-Life Followup [ 16 ], Adult Survey [ 17 ] and Cardiovascular Streams aim to provide at least ten years of longitudinal data on the cardiovascular health effects of the six-week PM 2.5 -generating mine fire event. These would complement the 10-year Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) investigating the relation between CVD and long-term ambient air pollution in a US urban setting [ 45 ], and the 10-year Corinthia study investigating the relation between CVD and environmental factors in rural and semi-rural areas of Greece [ 46 ] as important longitudinal studies contributing to the field of environmental cardiology.…”

Section: Discussionmentioning

confidence: 99%

Markers of Cardiovascular Disease among Adults Exposed to Smoke from the Hazelwood Coal Mine Fire

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Gao

et al. 2021

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Little research has examined the effects of high concentration, medium-duration smoke exposure on cardiovascular health. We investigated whether six weeks of exposure to smoke from the 2014 Hazelwood coal mine fire in Victoria (Australia), was associated with long-term clinical or subclinical cardiovascular disease approximately four years later, in adult residents of the towns of Morwell (exposed, n = 336) and Sale (unexposed, n = 162). The primary outcome was serum high sensitivity (hs) C-reactive protein (CRP). Blood pressure, electrocardiogram, flow mediated dilatation and serum levels of hs-troponin, N-terminal pro B-type natriuretic peptide and lipids were secondary outcomes. There was no significant difference in weighted median hsCRP levels between exposed and unexposed participants (1.9 mg/L vs. 1.6 mg/L, p = 0.273). Other outcomes were comparable between the groups. hsCRP was associated in a predictable manner with current smoking, obesity and use of lipid-lowering therapy. Four years after a 6-week coal mine fire, this study found no association between smoke exposure and markers of clinical or subclinical cardiovascular disease in exposed adults.

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Section: Discussionmentioning

confidence: 99%

Markers of Cardiovascular Disease among Adults Exposed to Smoke from the Hazelwood Coal Mine Fire

Betts

Dewar

Gao

et al. 2021

IJERPH

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“…In addition, primary studies have led to the discovery of several P2Y12 polymorphisms that influence ADP-induced platelet activation in healthy subjects [33]. It was suggested that these polymorphisms contribute to a decreased response to clopidogrel.…”

Section: Discussionmentioning

confidence: 99%

Genotyping, Platelet Activation, and Cardiovascular Outcome in Patients after Percutaneous Coronary Intervention: Two Pieces of the Puzzle of Clopidogrel Resistance

et al. 2017

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Objectives: Individual platelet responses to antiplatelet therapy depend on genetic, cellular, and clinical factors. CYP2C19 and P2Y12 receptor polymorphisms are implicated in platelet responses to antiplatelet treatment. We aimed to evaluate the impact of CYP2C19 and C34T P2Y12 genotyping on platelet reactivity and cardiovascular outcome in patients after percutaneous coronary intervention (PCI) on clopidogrel treatment. Methods: We enrolled 408 patients with stable coronary artery disease (CAD) receiving aspirin and clopidogrel (75 mg/day) 1 month after PCI. High on-treatment platelet reactivity was evaluated using the VerifyNow Assay in a subset of patients. CYP2C19*2 and C34T P2Y12 genotyping was performed by real-time polymerase chain reaction. The primary end point was the composite of death or hospitalization for cardiovascular causes, and patients were followed for a median time of 13 months. Results: In the total study population, 37% were carriers of at least 1 CYP2C19*2 loss-of-function allele, and 53% were carriers of at least 1 C34T loss-of-function allele. Interestingly, homozygotes of the CYP2C19*2 loss-of-function allele had significantly increased P2Y12 reaction units (PRU) (p = 0.007). However, PRU did not differ between carriers and noncarriers of the C34T loss-of-function allele (p = 0.41). Moreover, carriers of CYP2C19*2 had an increased hazard ratio (HR) for the occurrence of the primary end point (for carriers HR = 1.96, 95% CI 1.05-3.66, p = 0.03), whereas the C34T polymorphism had no impact on the cardiovascular outcome (p = 0.17). Finally, PRU was associated with cardiovascular outcome even after adjustment for the presence of any reduced function allele polymorphism. Conclusions: We documented a different effect of CYP2C19 and P2Y12 receptor polymorphisms on platelet reactivity and cardiovascular outcome in CAD patients after PCI on clopidogrel treatment. Importantly, increased platelet reactivity adversely affects the cardiovascular outcome independently of the studied polymorphisms.

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“…The Corinthia study is an epidemiological study with a cross-sectional and prospective longitudinal design. 15 It was carried out from October 2015 to February 2017. Permanent inhabitants of Corinth (n = 2043) aged 40 years or older were voluntarily enrolled.…”

Section: Methodsmentioning

confidence: 99%

Alcohol Consumption and Aortic Root Dilatation: Insights from the Corinthia Study

et al. 2019

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Aortic diameter and progression to thoracic aortic aneurysm are influenced by several factors. In this study, we investigated the association of alcohol consumption with aortic root and ascending aorta dilatation. In the context of the Corinthia study, we examined 1751 patients with echocardiography. Several demographic and clinical characteristics were recorded. Alcohol consumption was assessed based on a questionnaire of frequency, type, and quantity. Accordingly, patients were categorized as everyday alcohol consumers (EDACs) and as social drinkers (SoD). Everyday alcohol consumers were further categorized to group 1: 0 to 1 drink/d; group 2: 1 to 2 drinks/d; and group 3: ≥3 drinks/d. From the study population, 40% were categorized as EDAC and had an increased aortic root diameter (AoRD) and an elevated AoRD index compared with SoD. Interestingly, there was a stepwise increase in aortic root and ascending aorta diameter according to daily alcohol consumption. Specifically, patients consuming ≥3 drinks of alcohol/d had increased indexed aortic by 1.4 mm/m2 compared with SoD even after adjustment for possible confounders. Daily alcohol consumption is associated with increased aortic root diameter. These findings may have important clinical implications, especially in patients with borderline or dilated aortic root, and merit further investigation.

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Environment and cardiovascular disease: rationale of the Corinthia study

Cited by 30 publications

References 10 publications

Markers of Cardiovascular Disease among Adults Exposed to Smoke from the Hazelwood Coal Mine Fire

Markers of Cardiovascular Disease among Adults Exposed to Smoke from the Hazelwood Coal Mine Fire

Genotyping, Platelet Activation, and Cardiovascular Outcome in Patients after Percutaneous Coronary Intervention: Two Pieces of the Puzzle of Clopidogrel Resistance

Alcohol Consumption and Aortic Root Dilatation: Insights from the Corinthia Study

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