Reproductive history and dietary habits and breast cancer risk in Greenlandic Inuit: a case control study

Wielsøe, Maria; Guðmundsdóttir, Sigríður Lára; Bonefeld-Jörgensen, Eva Cecilie

doi:10.1016/j.puhe.2016.06.016

Cited by 16 publications

(15 citation statements)

References 39 publications

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“…Participants were recruited during 2000–2003 and 2011–2014. The sampling has been described earlier by Bonefeld-Jørgensen et al [11] for the period 2000–2003 and by Wielsøe et al [17] for the period 2011–2014.…”

Section: Methodsmentioning

confidence: 99%

“…The controls included from Cote et al [18] were from Nuuk and controls from Deutch et al were geographically more widespread [19] and included to ensure that the controls represented the general population and the cases. The controls recruited during 2011–2014 were patients with non malign diagnoses at the Dronning Ingrids Hospital and frequency matched on age and geographical living area [17]. The majority of the hospital-controls were admitted at the Department of Orthopaedic Surgery, and others were admitted at the Department of Gynaecology and Obstetrics and diagnosed with non malignant abnormities in uterus, ovaries and breast, including cysts, metrorrhagia, menorrhagia, and cystocele.…”

Section: Methodsmentioning

confidence: 99%

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Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study

2017

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BackgroundEnvironmental Persistent Organic Pollutants (POPs) can alter the hormone homeostasis by mimicking, interfering or blocking the function of hormones; moreover POPs are hypothesized to modify the risk of breast cancer. The association between POPs and breast cancer has been widely studied but the conclusions are inconsistent. The present study examined the associations between serum levels of POPs and breast cancer with focus on the highly exposed Greenlandic Inuit population.MethodsThe study design was a case-control study of Inuit women from Greenland. The participants were asked to complete a questionnaire with information on reproductive history and lifestyle and to provide a blood sample. The sampling was carried out in two time periods (2000–2003 and 2011–2014). The serum levels were determined of 14 polychlorinated biphenyls (PCBs), 11 organochlorine pesticides (OCPs), 16 perfluoroalkyl acids (PFAAs), 1 polybrominated biphenyl (PBB), and 9 polybrominated diphenyl ethers (PBDEs). Independent samples t-test was used to compare differences between cases and controls and odds ratios (OR) adjusted for identified confounders were obtained using logistic regression.ResultsThe study population included 77 breast cancer cases and 84 controls. The majority of the measured compounds declined significantly from 2000 – 2003 to 2011–2014. However, for the perfluorinated carboxylic acids (PFCAs) an increase was observed. The serum levels were significantly higher in cases compared to controls for the majority of the compounds, and after adjusting for age the difference was maintained for ∑OCP, dichlorodiphenyldichloroethylene (p,p′-DDE), ∑PFAA, ∑perfluorinated sulfonic acids (PFSA), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS). For the lipophilic POPs, high serum levels (middel/highest vs. lowest tertile) of ∑PCB, ∑estrgoenicPCB, PCB99, PCB138, PCB153, PCB170, PCB170, and PCB183 was associated with breast cancer risk; for the amphiphilic PFAAs, high serum levels of ∑PFAA, ∑PFCA, ∑PFSA, perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), PFHxS, and PFOS were associated with breast cancer risk.ConclusionSignificant, positive associations between breast cancer risk and PCBs and PFAAs were observed. The associations indicate that environmental exposure to POPs can be a factor increasing the risk for breast cancer in Inuit women.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0269-6) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study

2017

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“… were geographically more spread out and included to ensure that the controls were representative for the population of cases. The controls recruited during 2011–2014 were patients with non‐malignant diagnoses at Dronning Ingrid's Hospital, Nuuk . The majority of the hospital controls were admitted at Department of Orthopaedic Surgery, and others were admitted at Department of Gynaecology and Obstetrics and diagnosed with non‐malignant abnormalities in uterus, ovaries and breast, including cysts, metrorrhagia, menorrhagia and cystocele.…”

Section: Methodsmentioning

confidence: 99%

Genetic Variations, Exposure to Persistent Organic Pollutants and Breast Cancer Risk – A Greenlandic Case–Control Study

Wielsøe

Eiberg

Ghisari

et al. 2018

Basic Clin Pharma Tox

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This study investigated the effects of single nucleotide polymorphisms (SNPs) in xenobiotic and steroid hormone-metabolizing genes in relation to breast cancer risk and explored possible effect modifications on persistent organic pollutants (POPs) and breast cancer associations. The study also assessed effects of Greenlandic BRCA1 founder mutations. Greenlandic Inuit women (77 cases and 84 controls) were included. We determined two founder mutations in BRCA1: Cys39Gly (rs80357164) and 4684delCC, and five SNPs in xenobiotic and oestrogen-metabolizing genes: CYP17A1 -34T>C (rs743572), CYP19A1 *19C>T (rs10046), CYP1A1 Ile462Val (rs1048943), CYP1B Leu432Val (rs1056836) and COMT Val158Met (rs4680). We used chi-square test for comparison of categorical variables between groups. Odds ratio (OR) estimates with 95% confidence interval (95%CI) were obtained using logistic regression models. The variant allele of BRCA1 Cys39Gly increased breast cancer risk (Gly/Cys versus Cys/Cys, OR: 12.2, 95%CI: 1.53; 98.1), and carriers of the variant allele of CYP17A1 -34T>C had reduced risk (CT+CC versus TT, OR: 0.44, 95%CI: 0.21; 0.93). CYP17A1 -34T>C was an effect modifier on the association between perfluoroalkyl acids (PFAAs) and breast cancer risk (∑PFAA, ratio of OR: 0.18, 95%CI: 0.03; 0.97). Non-significant modifying tendencies were seen for the other SNPs on the effect of polychlorinated biphenyls, organochlorine pesticides and PFAAs. In summary, the BRCA1 Cys39Gly and CYP17A1 -34T>C genetic variations were associated with breast cancer risk. Our results indicate that the evaluated genetic variants modify the effects of POP exposure on breast cancer risk; however, further studies are needed to document the data from the relatively small sample size.

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“…34,35 Controls recruited during 2011-2014 were patients with non-malignant diagnoses at Dronning Ingrid's Hospital, Nuuk. 36 In the inclusion, although not matched, we attempted to obtain similar distribution among cases and controls with regard to age and geographical area (region) of residence. All Greenlandic breast cancer cases are treated at Droning Ingrid's Hospital in Nuuk; however, at other departments (from where controls were included), a higher percentage of patients from Nuuk may be present.…”

Section: Study Participantsmentioning

confidence: 99%

DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women

Wielsøe

Tarantini

Bollati

et al. 2020

Basic Clin Pharma Tox

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Several studies have found aberrant DNA methylation levels in breast cancer cases, but factors influencing DNA methylation patterns and the mechanisms are not well understood. This case–control study evaluated blood methylation level of two repetitive elements and selected breast cancer‐related genes in relation to breast cancer risk, and the associations with serum level of persistent organic pollutants (POPs) and breast cancer risk factors in Greenlandic Inuit. DNA methylation was determined using bisulphite pyrosequencing in blood from 74 breast cancer cases and 80 controls. Using first tertile as reference, the following was observed. Positive associations for ATM in second tertile (OR: 2.33, 95% CI: 1.04; 5.23) and ESR2 in third tertile (OR: 2.22, 95% CI: 0.97; 5.05) suggest an increased breast cancer risk with high DNA methylation. LINE‐1 methylation was lower in cases than controls. In third tertile (OR: 0.42, 95% CI: 0.18; 0.98), associations suggest in accordance with the literature an increased risk of breast cancer with LINE‐1 hypomethylation. Among controls, significant associations between methylation levels and serum level of POPs and breast cancer risk factors (age, body mass index, cotinine level) were found. Thus, breast cancer risk factors and POPs may alter the risk through changes in methylation levels; further studies are needed to elucidate the mechanisms.

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Reproductive history and dietary habits and breast cancer risk in Greenlandic Inuit: a case control study

Cited by 16 publications

References 39 publications

Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study

Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study

Genetic Variations, Exposure to Persistent Organic Pollutants and Breast Cancer Risk – A Greenlandic Case–Control Study

DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women

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