The Relationship Between Early-Stage Knee Osteoarthritis and Lower-Extremity Alignment, Joint Laxity, and Subjective Scores of Pain, Stiffness, and Function
Abstract:Context:Knee osteoarthritis (OA) is a debilitating disease that affects an estimated 27 million Americans. Changes in lowerextremity alignment and joint laxity have been found to redistribute the medial and/or lateral loads at the joint. However, the effect that changes in anteroposterior knee-joint laxity have on lower-extremity alignment and function in individuals with knee OA remains unclear.Objective:To examine anteroposterior knee-joint laxity, lower-extremity alignment, and subjective pain, stiffness, a… Show more
“…Obtaining stressed X-rays to determine functional laxity ranges however, is not practical for routine TKA pre-operative analysis and consequently we investigated whether patient specific knee laxity could be predicted from anatomical features on CT scan and radiographs. Previous investigations have found correlations between knee osteoarthritis, alignment and laxity [8], but have not investigated morphological measures on a 3 dimensional patient specific basis. At this stage knee laxity at 20° flexion has shown a significant correlation, indicating that with greater data, bone morphology may assist in characterising the soft tissue profile.…”
Currently, pre-operative analysis of soft-tissue balance is limited to measures of passive laxity rather than active laxity. By including active laxity data, a more comprehensive surgical plan can be delivered, however there are no measures for active laxity currently in routine use. Therefore, the validation of a proxy measure based on routine collected imaging is valuable. This study aimed to determine whether coronal knee laxity can be predicted from pre-operative alignment and bony morphology of the knee. Fifty-eight patients with pre-operative CT and stressed x-ray imaging for activity laxity were analysed to identify anatomical landmarks and determine varus-valgus laxity ranges for a range of flexion angles with the joint subjected to lateral forces. Correlations between anatomical and alignment parameters, vs laxity ranges and midpoints were determined using pairwise complete Pearson linear correlation analyses. Of the 17 anatomical/alignment measurements studied, 8 correlated significantly with the knee laxity range’s midpoint at 20 ̊ flexion, with the strongest correlation being with supine coronal alignment (r = 0.95, p < 0.001); the findings were similar at 45-90 ̊. Compared to knee laxity midpoint, knee laxity range was not as strongly correlated with anatomical and alignment parameters, with only 3 anatomical parameters correlated significantly with laxity range at 20 ̊ flexion and none at 45-90 ̊ flexion. These results suggest morphological measurements and anatomical characteristics may help define functional coronal laxity range of the knee.
“…Obtaining stressed X-rays to determine functional laxity ranges however, is not practical for routine TKA pre-operative analysis and consequently we investigated whether patient specific knee laxity could be predicted from anatomical features on CT scan and radiographs. Previous investigations have found correlations between knee osteoarthritis, alignment and laxity [8], but have not investigated morphological measures on a 3 dimensional patient specific basis. At this stage knee laxity at 20° flexion has shown a significant correlation, indicating that with greater data, bone morphology may assist in characterising the soft tissue profile.…”
Currently, pre-operative analysis of soft-tissue balance is limited to measures of passive laxity rather than active laxity. By including active laxity data, a more comprehensive surgical plan can be delivered, however there are no measures for active laxity currently in routine use. Therefore, the validation of a proxy measure based on routine collected imaging is valuable. This study aimed to determine whether coronal knee laxity can be predicted from pre-operative alignment and bony morphology of the knee. Fifty-eight patients with pre-operative CT and stressed x-ray imaging for activity laxity were analysed to identify anatomical landmarks and determine varus-valgus laxity ranges for a range of flexion angles with the joint subjected to lateral forces. Correlations between anatomical and alignment parameters, vs laxity ranges and midpoints were determined using pairwise complete Pearson linear correlation analyses. Of the 17 anatomical/alignment measurements studied, 8 correlated significantly with the knee laxity range’s midpoint at 20 ̊ flexion, with the strongest correlation being with supine coronal alignment (r = 0.95, p < 0.001); the findings were similar at 45-90 ̊. Compared to knee laxity midpoint, knee laxity range was not as strongly correlated with anatomical and alignment parameters, with only 3 anatomical parameters correlated significantly with laxity range at 20 ̊ flexion and none at 45-90 ̊ flexion. These results suggest morphological measurements and anatomical characteristics may help define functional coronal laxity range of the knee.
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