Massive Cerebral Infarction Following Facial Fat Injection

Shen, Xiao; Li, Qi; Hengshu, Zhang

doi:10.1007/s00266-016-0681-2

Cited by 18 publications

(15 citation statements)

References 10 publications

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“…Having the same clinical symptoms, with a highlight over the neurological features and no traumatic involvement, fat embolism syndrome could be expressed as a cerebral fat embolism, the latter one being able to worsen the prognostic of the patients. Nevertheless, in a cerebral fat embolism, neurological manifestation may mask respiratory symptoms or they may even be absent, making diagnosis challenging [5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Fat Embolism Syndrome Mimicking a COVID-19 Infection

Alexa

Onuţu

2021

Case Reports in Critical Care

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Fat embolism syndrome (FES) is a multiple organ disorder that can appear after pelvic and long bone fractures. The most common clinical finding is hypoxia, accompanied by diffuse petechiae, alveolar infiltrates, altered mental status, fever, polypnea, and tachycardia. We present a mild FES case on a 32-year-old man with no medical history admitted for an orthopedic procedure, following both tibia and fibulae fractures. Thirty hours postoperatively, he developed respiratory failure with altered mental status and needed admission in the intensive care unit. The chest radiography and later chest tomography raised the suspicion of a COVID-19 disease, even if our first suspicion was FES. After being carefully investigated in a dedicated COVID-19 ward and three negative RT-PCR SARS-CoV-2 tests, he returned to continue supportive treatment in the orthopedic intensive care ward. His evolution was favorable with discharge at ten days, without sequelae. In the context of the SARS CoV-2 pandemic, differential diagnosis has become an increasingly challenging process. Added to the variety of preexisting respiratory diseases and disorders, the COVID-19 infection, with its symptomatology so similar to multiple other pulmonary diseases, must not cloud our clinical judgement.

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Section: Discussionmentioning

confidence: 99%

Fat Embolism Syndrome Mimicking a COVID-19 Infection

Alexa

Onuţu

2021

Case Reports in Critical Care

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“…Fat injection into the face is occasionally associated with complications when fat enters facial arteries and subsequently orbital and cerebral arteries, causing vision loss or cerebral infarction . Yoon et al reported a case of acute fatal stroke following autologous fat injection to the face.…”

Section: Discussionmentioning

confidence: 99%

Fatal Fat Embolism After Penis Enlargement by Autologous Fat Transfer: A Case Report and Review of the Literature

Zilg

Råsten-Almqvist

2017

Journal of Forensic Sciences

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Fat embolism is an incidental finding in cases of long bone fractures or other trauma, but it is also associated with liposuction and autologous fat transfer, a procedure where fat from liposuction is injected back into the same patient's face, breast, buttocks or penis. We here present a case of sudden death by fat embolism in a healthy young male, caused by a simple penis enlargement procedure, in which fat was injected into the penis shaft. We suggest that the risk of fat embolization might be higher when pretraumatized tissue is subjected to fat injection, like in this case, where a penis elongation was performed before the fat injection.

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“…Fat grafting does carry a risk of intra-luminal injection causing necrosis and infarct of the end organ tissue, which in the head and neck can be devastating and there are numerous reports of blindness, facial skin loss, fat embolic syndrome and cerebral infarct (37)(38)(39).…”

Section: Risks Of Autologous Fat Graftingmentioning

confidence: 99%

Autologous fat grafting in the face and neck-Multinational trends and knowledge of the safety, applications and indications considering oncologic risk potential

Fiedler¹,

Saleh²,

Mukrowsky³

2021

Preprint

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Introduction Autologous fat grafting (AFG) has both aesthetic and reconstructive applications. Described by Neuber in 1893 there are numerous applications of AFG as the body of evidence for its use has expanded. The earliest controversies were evident in lipofilling for breast defects post-oncological treatment, and to this day some countries do not allow it for fear of inducing tumourogenesis in an oncologically ablated field. Adipose-derived stem cells (ASCs) have been shown pro-oncologic behaviour in xenografts, however, this has not been reproduced in clinical observations thus far. Material and Methods We sought to review contemporary harvesting and processing techniques for AFG in the craniofacial region, therefore distributed a survey to evaluate the opinion and clinical impact of oncological risk across four European countries with possibly differing clinical attitudes. Results In the craniofacial region AFG is mostly used for aesthetic indications, cannula hand-held aspiration and centrifugation seem to be the predominant harvesting and processing techniques. Half of our respondents tell patients about the possibility of pro-oncologic behaviour of AFG. We found no significant geographical differences between the German-speaking and the English groups concerning their harvesting and processing technique. German participants seem to perform AFG more often and mostly use it for cosmetic and post-cancer treatment sequelae, English participants homogenically use AFG for cosmetic reasons. Conclusion Theoretical pro-oncologic behaviour of craniofacial AFG does not deter surgeons. Perhaps, we shouldn’t consider discussing this complex area of oncogenesis with patients as there is no elevated risk from what we know.

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Massive Cerebral Infarction Following Facial Fat Injection

Abstract: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the A5 online Instructions to Authors www.springer.com/00266.

Cited by 18 publications

References 10 publications

Fat Embolism Syndrome Mimicking a COVID-19 Infection

Fat Embolism Syndrome Mimicking a COVID-19 Infection

Fatal Fat Embolism After Penis Enlargement by Autologous Fat Transfer: A Case Report and Review of the Literature

Autologous fat grafting in the face and neck-Multinational trends and knowledge of the safety, applications and indications considering oncologic risk potential

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