Analysis of polymorphism and hepatic expression of duodenal cytochrome b in chronic hepatitis C

Rudnicka, Alina; Woziwodzka, Anna; Wróblewska, Anna; Rybicka, Magda; Bielawski, Krzysztof Piotr; Sikorska, Katarzyna; Bernat, Agnieszka

doi:10.1111/jgh.13495

Cited by 3 publications

(3 citation statements)

References 13 publications

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“… 24 Based on extensive references, CYBRD1 mainly contributed to the transportation of glucose and other sugars, 25 metal ions, bile salts, and organic acids, as well as the absorption of mineral. 26 CYBRD1 has been proved to be involved in the development of HFE hemochromatosis, 27 chronic hepatitis C, 28 and alcoholic liver disease. 29 Additionally, Lemler DJ et al demonstrated that DCYTB was a potential biomarker for breast cancer and exerted its functional effect through an iron‐independent manner.…”

Section: Introductionmentioning

confidence: 99%

miR‐423‐3p activates FAK signaling pathway to drive EMT process and tumor growth in lung adenocarcinoma through targeting CYBRD1

Huang

Zhu

et al. 2021

Clinical Laboratory Analysis

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Lung cancer is a malignant tumor originated from the bronchial mucosa or glands of the lungs, 1,2 which has characteristics of family clustering and genetic susceptibility. 3,4 According to preventive pathology, lung cancer is classified into two categories: small cell carcinoma and non-small-cell carcinoma. 5 Among them, non-smallcell carcinoma includes squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. 6 Lung adenocarcinoma (LUAD) is a type of lung cancer, accounting for 40%-55% in all lung cancer cases.

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Section: Introductionmentioning

confidence: 99%

miR‐423‐3p activates FAK signaling pathway to drive EMT process and tumor growth in lung adenocarcinoma through targeting CYBRD1

Huang

Zhu

et al. 2021

Clinical Laboratory Analysis

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“…The CYBRD1 rs884409 polymorphism associates with variation in serum transferrin saturation and ferritin concentration in patients with HFE C282Y mutation and the mutated allele reduces CYBRD1 promoter activity by 30% [ 39 , 40 ]. CYBRD1 rs884409 was found previously to associate with liver inflammation, liver enzymes and bilirubin in CHC patients [ 20 ]. In our study this SNP was linked with liver inflammation grade ( Table S4 ) and liver steatosis ( Table 1 , Table S5 ) as well as serum liver enzymes, bilirubin, and iron concentration ( Table S6 ).…”

Section: Discussionmentioning

confidence: 99%

“…All patients were treated in the Department of Infectious Diseases, Medical University of Gdansk, Poland. Selected patients were analyzed in previous studies [ 18 , 20 ]. The baseline characteristics of patients are shown in Table S1 .…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms Related to Iron Homeostasis Associate with Liver Disease in Chronic Hepatitis C

Wróblewska

Woziwodzka

Rybicka

et al. 2023

Viruses

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Dysregulation of iron metabolism in chronic hepatitis C (CHC) is a significant risk factor for hepatic cirrhosis and cancer. We studied if known genetic variants related to iron homeostasis associate with liver disease progression in CHC. Retrospective analysis included 249 CHC patients qualified for antiviral therapy between 2004 and 2014. For all patients, nine SNPs within HFE, TFR2, HDAC2, HDAC3, HDAC5, TMPRSS6, and CYBRD1 genes were genotyped. Expression of selected iron–related genes, was determined with qRT-PCR in 124 liver biopsies, and mRNA expression of co-inhibitory receptors (PD-1, Tim3, CTLA4) was measured in 79 liver samples. CYBRD1 rs884409, HDAC5 rs368328, TFR2 rs7385804, and TMPRSS6 rs855791 associated with histopathological changes in liver tissue at baseline. The combination of minor allele in HDAC3 rs976552 and CYBRD1 rs884409 linked with higher prevalence of hepatocellular carcinoma (HCC) during follow up (OR 8.1 CI 2.2–29.2; p = 0.001). Minor allele in HDAC3 rs976552 associated with lower hepatic expression of CTLA4. Tested polymorphisms related to iron homeostasis associate with histopathological changes in the liver. The presence of both HDAC3 rs976552 G and CYBRD1 rs884409 G alleles correlates with HCC occurrence, especially in the group of patients with elevated AST (>129 IU/L). rs976552 in HDAC3 could impact immunological processes associated with carcinogenesis in CHC.

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Serum or plasma ferritin concentration as an index of iron deficiency and overload

Garcı́a-Casal

Pasricha

Martinez

et al. 2021

Cochrane Database of Systematic Reviews

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Analysis of polymorphism and hepatic expression of duodenal cytochrome b in chronic hepatitis C

Abstract: These results implicate CYBRD1 involvement in iron homeostasis in CHC.

Cited by 3 publications

References 13 publications

miR‐423‐3p activates FAK signaling pathway to drive EMT process and tumor growth in lung adenocarcinoma through targeting CYBRD1

miR‐423‐3p activates FAK signaling pathway to drive EMT process and tumor growth in lung adenocarcinoma through targeting CYBRD1

Polymorphisms Related to Iron Homeostasis Associate with Liver Disease in Chronic Hepatitis C

Serum or plasma ferritin concentration as an index of iron deficiency and overload

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