Amino Acid–based Formula in Cow's Milk Allergy

Canani, Roberto Berni; Nocerino, Rita; Frediani, T.; Lucarelli, Sandra; Scala, Carmen Di; Varin, Elena; Leone, Ludovica; Muraro, Antonella; Agostoni, Carlo

doi:10.1097/mpg.0000000000001337

Cited by 35 publications

(39 citation statements)

References 25 publications

(41 reference statements)

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“…Glutamic acid, in particular, has been suggested to downregulate appetite during feeding by interacting with specific receptors in the oral cavity and gastrointestinal tract. However recent studies have shown no negative effect of feeding AA formulas in infants; on the contrary, they may be beneficial for growth [ 65 ].…”

Section: The Role Of Diet In the Management Of Food Allergymentioning

confidence: 99%

The Role of Nutritional Aspects in Food Allergy: Prevention and Management

et al. 2017

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The prevalence of food allergy in childhood appears to be increasing in both developed and transitional countries. The aim of this paper is to review and summarise key findings in the prevention and management of food allergy, focusing on the role of dietary components and nutritional habits in the development and optimal functioning of the immune system. Essential fatty acids, zinc and vitamin D are likely to enhance the anti-inflammatory and antioxidative barrier and promote immunologic tolerance. Additionally, nutritional components such as pre- and probiotics represent a novel research approach in the attempt to induce a tolerogenic immune environment. For all these reasons, the traditional avoidance diet has been, in recent years, completely reconsidered. New findings on the protective effect of an increased diversity of food introduced in the first year of life on allergic diseases are consistent with the hypothesis that exposure to a variety of food antigens during early life might play a role in the development of immune tolerance. Accordingly, therapeutic (and even preventive) interventions should be planned on an individual basis.

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Section: The Role Of Diet In the Management Of Food Allergymentioning

confidence: 99%

The Role of Nutritional Aspects in Food Allergy: Prevention and Management

et al. 2017

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“…Paediatrician recommendations stress careful nutritional guidance to manage CMA[3,6,28,29] , including the use of an adapted formula that meets the nutritional needs of non-breastfed infants and young children[30,31]. Therefore, evidence on the safety and suitability of these formulas should be obtained from children with CMA in particular, as recently reported for some eHFs[23,24] or AAFs[32,33]. Growth parameters of the children fed the TeHCF were within normal range throughout the 3-mo period, indicating that this hypoallergenic formula is safe.…”

Section: Discussionmentioning

confidence: 99%

Hypoallergenicity of a thickened hydrolyzed formula in children with cow’s milk allergy

Rossetti

Cucchiara

et al. 2019

WJCC

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BACKGROUND Allergy to cow’s milk is the most frequent allergy occurring in infants and young children. The dietary management of these patients consists of the elimination of any cow’s milk proteins from the diet, and for formula-fed infants, the substitution of the usual infant formula with an adapted formula that is generally based on extensively hydrolyzed cow’s milk proteins. The American Academy of Pediatrics has established specific criteria to confirm the hypoallergenicity of a formula intended for these children. AIM To assess the hypoallergenicity of a new thickened extensively hydrolyzed casein-based formula (TeHCF) in children with cow’s milk allergy (CMA). METHODS Children diagnosed with CMA through a double-blind placebo-controlled food challenge (DBPCFC) were randomly administered increased doses of a placebo formula or the TeHCF [Allernova, new thickener including fibres (Novalac)] under double-blind conditions and medical surveillance on two separate days. Otherwise, both of these formulas and a cow’s milk-based formula were randomly introduced to children who were highly suspected of having CMA on three separate days. Immediate and late reactions occurring after the introduction of any of these formulas were thoroughly recorded by the physician at the hospital and reported by parents to the physician after hospital discharge, respectively. If the children tolerated the TeHCF during the DBPCFC, they were exclusively fed this formula during a 3-mo period where potential allergic symptoms, anthropometric parameters, as secondary outcomes, and adverse events were registered. The Cow’s Milk-related Symptoms Score (CoMiSS TM ) was assessed and anthropometric parameters were compared to World Health Organization (WHO) reference data. RESULTS Of the 30 children included in the study, the CMA diagnosis of 29 (mean age: 8.03 ± 7.43 mo) patients was confirmed by a DBPCFC. The children all tolerated the TeHCF during both the challenge and the subsequent 3-mo feeding period, which they all completed. During the latter period, the CoMiSS TM remained at a very low level, never exceeding its baseline value (1.4 ± 2.0), growth parameters were within WHO reference standards and no adverse event related to the TeHCF was reported. Over the first week of this period, the proportion of patients with digestive discomfort significantly decreased from 20.7% (6/29) to 3.4% (1/29), P = 0.025. The proportion of satisfaction with the overall effect of the formula reported by the parents and investigator was high, as was the formula acceptability by the child. CONCLUSION The new TeHCF meets the hypoallergenicity criteria according to the American Academy of Pediatrics standards, confirming that the tested TeHCF is adapted to the dietary management of children with CMA. Moreover, growth was adequate in the included p...

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“…Однако при этом, даже если удается компенсировать дефицит белковой составляющей рациона, потребление витами-нов и минеральных веществ остается недостаточным. [31][32][33] Миф 11. «Нужно вылечить дисбактериоз, и аллергия пройдет» Сегодня уже не вызывает сомнений, что микробиота кишечника является фактором, в значительной степени влияющим на здоровье человека.…”

Section: козье молоко не является гипоаллергенным при ме-нение продуunclassified

Twelve Myths About Food Allergies in Children

Макарова¹

2017

Vopr. sovr. pediatr.

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Amino Acid–based Formula in Cow's Milk Allergy

Abstract: Long-term treatment with AAF is safe and allows adequate body growth in children with CMA.

Cited by 35 publications

References 25 publications

The Role of Nutritional Aspects in Food Allergy: Prevention and Management

The Role of Nutritional Aspects in Food Allergy: Prevention and Management

Hypoallergenicity of a thickened hydrolyzed formula in children with cow’s milk allergy

Twelve Myths About Food Allergies in Children

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