Blood biochemistry, thyroid hormones, and performance in broilers with ascites caused by caffeine

Abstract

Previously, we demonstrated that caffeine, a natural alkaloid, stimulates increased incidences of pulmonary hypertension syndrome (ascites) in broilers. The present study was designed to evaluate the ergogenic effects of caffeine on broiler performance and blood parameters. One-hundred-and-ninety-two Ross 308 male broiler chicks were randomly assigned at one d of age to 16 pens with 4 treatment groups. On d 3, the drinking water was supplemented with caffeine at levels of zero, 12.5, 25, and 50 mg/kg BW/day. Caffeine supplementation linearly improved (P < 0.01) body weight gain (BWG) and the feed conversion ratio (FCR); however, feed intake was not affected by caffeine (P > 0.05). On d 28, increasing caffeine supplementation caused linear reductions in plasma albumin, total protein, globulin, and triglyceride concentrations, and caffeine supplementation increased plasma uric acid concentrations (P < 0.05). On d 42, caffeine did not consistently affect plasma albumin, globulin, triglyceride, total protein, uric acid, or urea concentrations (P > 0.05), whereas plasma glucose concentrations increased linearly with increasing caffeine levels (P < 0.05). Plasma T concentrations were not affected by caffeine (P > 0.05), but plasma T concentrations were reduced by caffeine supplementation on d 28 and 42 (P < 0.05). The T:T ratios also were reduced by caffeine supplementation on d 42. Skin temperature was not influenced by caffeine supplementation (P > 0.05). There was a negative correlation between thyroid hormone concentrations and BW on d 42 (P < 0.05). It can be concluded that caffeine supplementation at the levels of 12.5 to 25 mg/kg BW/day increased BWG, decreased FCR and T, and significantly altered blood biochemistry parameters.

Lactose Glycation of the Maillard-Type Impairs the Benefits of Caseinate Digest to the Weaned Rats for Intestinal Morphology and Serum Biochemistry

“…The rats fed with GCN digest thus obtained extra oxidative stress, implying that the performed caseinate lactose-glycation of the Maillard-type endowed GCN digest with an unfavorable ability in the body. Furthermore, serum glucose content is governed by many factors including carbohydrate intake, carbohydrate digestibility, glycogenolysis, and insulin sensitivity [ 47 , 51 ]. The rats fed with GCN digest had inhibited α-amylase activity but higher serum glucose, and an investigation is also needed to further reveal this phenomenon.…”

Gestational caffeine exposure acts as a fetal thyroid-cytokine disruptor by activating caspase-3/BAX/Bcl-2/Cox2/NF-κB at ED 20

“…Accordingly, supplementation with caffeine reduces the T3 level on days 28 and 42, and the T3/T4 ratio on day 42 only. 63 Caffeine could induce its action either by increasing the metabolic rate of premature infants, 41 elevating the release and function of TSH 24,64 or reducing the height of thyroid follicles. 24 In rats, Son et al 65 reported that caffeine could cooperate with iodine deficiency partially via the hypothalamic-pituitary-thyroid axis (HPTA) to increase the TSH level, thyroid weights, and number of thyroidal lesions.…”

Functional Quails Eggs using Enriched Spirulina during the Biosorption Process

“…Due to the direct effects of gamma-linolenic acid on the immune system and use in the treatment of many diseases, there has been a great interest in producing high concentrations of gamma-linoleic acid (Andrade, 2018). Numerous studies have been done on the enrichment of quail feed with the use of Spirulina platensis (Boiago et al, 2019), lycopene (Sahin et al, 2008), fish oil (Kamely et al, 2016), vegetation such as Liquor ice (Doğan et al, 2018), and rice bran (Gopinger et al, 2016), to enrich its eggs (Wang et al, 2007). One of the side effects of using antibiotics is the formation of antibiotic resistance.…”