GSK-3β promotes PA-induced apoptosis through changing β-arrestin 2 nucleus location in H9c2 cardiomyocytes

Chang, Fen; Liu, Jing; Fu, Hui; Wang, Jinlan; Li, Fang; Yue, Hong-Wei; Li, Wenjing; Zhao, Jing; Yin, Deling

doi:10.1007/s10495-016-1272-z

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…Accumulating evidence has uncovered the role of β-arrestin2 in apoptosis (23,24) and the dual effect of β-arrestin2 in apoptosis (24)(25)(26)(27). Under different conditions, β-arrestin2 can be pro-apoptotic or anti-apoptotic (28)(29)(30). In the present study, 5-FU, as a core drug for CRC, was selected as a drug-interfering factor.…”

Section: Discussionmentioning

confidence: 96%

β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer

Ren

Wang

et al. 2018

Oncol Rep

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It has been demonstrated that β‑arrestin2 is involved in the initiation and development of many types of cancers. However, its role in colorectal cancer (CRC) remains poorly understood. The present study investigated the role of β‑arrestin2 in CRC using CRC patient tissues as well as the LoVo and HCT116 CRC cell lines. Briefly, significantly higher expression of β‑arrestin2 was observed in CRC tissues compared with normal colon tissues. In addition, the downregulation of β‑arrestin2 reduced 5‑FU‑induced apoptosis in the LoVo cells, while the overexpression of β‑arrestin2 increased the apoptosis of HCT116 cells in vitro. Furthermore, the downregulation of β‑arrestin2 reduced the expression of the pro‑apoptotic proteins cleaved‑caspase‑3 and Bax, and increased the expression of the anti‑apoptotic protein Bcl‑2 after 5‑FU treatment. In addition, the expression of p‑p65 was increased after the β‑arrestin2 downregulation and was decreased after the β‑arrestin2 overexpression. However, β‑arrestin2 downregulation had no effect on the proliferation, migration and invasion capacity of the LoVo cells. In conclusion, these results indicated that β‑arrestin2 promoted 5‑FU‑induced CRC cell apoptosis via the NF‑κB pathway and may be used as a prognosis marker for CRC.

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Section: Discussionmentioning

confidence: 96%

β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer

Ren

Wang

et al. 2018

Oncol Rep

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“…The function of GSK-3β in promoting cell apoptosis has been wellelucidated. It not only promoted the signal transduction of apoptosis 46 but also inhibited the expression of antiapoptotic factors. 47 Presumably, the sudden drop in the ovarian index in the ZEA1.5 group 30 was largely due to the apoptosis and atresia of the oocyte, which was in accordance with the results of the increase in GSK-3β.…”

Section: ■ Discussionmentioning

confidence: 99%

Zearalenone-Promoted Follicle Growth through Modulation of Wnt-1/β-Catenin Signaling Pathway and Expression of Estrogen Receptor Genes in Ovaries of Postweaning Piglets

Yang

Zhou

Huang

et al. 2018

J. Agric. Food Chem.

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Feedstuffs are severely contaminated by zearalenone (ZEA) worldwide. A specific dietary level of ZEA could cause malformations of the reproductive organs of sows, false estrus, decreased litter size, and abortion. However, the underlying mechanisms are still not clear. The objectives of the present study were to assess the effects of ZEA on morphology, distribution, and expression of estrogen receptors (ERα and ERβ) in the ovaries of postweaning piglets. Furthermore, the relationship between ERs/glycogen synthase kinase (GSK)-3β-dependent pathways mediated by ZEA and the Wnt-1/β-catenin signaling pathway was examined. Forty healthy weaning piglets were allocated to the following four treatment groups: piglets fed with basal diet only (control), and ZEA0.5, ZEA1.0, and ZEA1.5, which were fed basal diets supplemented with ZEA at 0.5, 1.0, and 1.5 mg·kg, respectively. Then, the expression of GSK-3β, ERα, ERβ, and Wnt-1/β-catenin were examined histomorphologically and immunohistochemically. Results showed that the proportion of primordial follicles (PrF's) decreased ( p < 0.001) but that of atretic primordial follicles (APFs) increased ( p < 0.001) with increasing dietary ZEA levels. More interestingly, the immunopositivity of ERβ in the ovaries was stronger than that of ERα with the same treatment. The relative mRNA and protein expression levels of ERα, ERβ, Wnt-1, β-catenin, and GSK-3β in the ovaries of postweaning gilts increased linearly ( p < 0.05) as dietary ZEA concentrations increased. Moreover, the accumulation of Wnt-1 and β-catenin in the ovaries indicated that ZEA activated the Wnt-1/β-catenin pathway, mediated by ERs/GSK-3β. Our results strongly suggested that ovarian follicles in the ZEA (0.5-1.5 mg·kg)-treated groups were highly proliferative state, indicating that ZEA promoted ovarian development. The results also suggested that ZEA activates the ERs/GSK-3β-dependent Wnt-1/β-catenin signaling pathway, indicating its important role in accelerating development of the ovaries.

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“…C16:0 (palmitic acid), as one of the saturated fatty acids, plays a substantial role in growth and metabolism of body cells. Related studies indicate that the palmitic acid is able to induce cell death and autophagy, and change the phospholipid level in the myocardial cell, thus posing an impact on the functions of mitochondria in cells (Ostrander et al, 2001;Chang et al, 2016). This study shows that the content of C16:0 in yolk of ordinary eggs and native eggs was the highest, without significant difference.…”

Section: Discussionmentioning

confidence: 57%

A Comparative Study of Fatty Acid Content in Yolk of Native Eggs and Ordinary Eggs Available in the Market

Duan¹,

Li²,

Li³

et al. 2020

PJZ

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In this test, gas chromatographic method was used to determine the fatty acid content of ordinary eggs and native eggs of brands A, B and C. The results indicate that: In the test samples, totally 7 types of SFA, 7 types of MUFA, and 8 types of PUFA were detected. Specifically, no significant difference was found in the content of C14:0~C18:0 (P>0.05). The content of C16:0 in the yolk of both native eggs and ordinary eggs was high; in the yolk of native eggs of the three brands, the content of C14:1 and C16:1 was both significantly higher than that of ordinary eggs (P<0.05); the content of C17:1 in yolk of native eggs of brand A was significantly higher than that of brand C native eggs (P<0.05); the content of C18: 2n6t and C20:2 in yolk of ordinary eggs and brand C eggs was significantly higher than that of brand A and B native eggs (P<0.05); the content of C18:2n6c in yolk of ordinary eggs was significantly higher than that of brands A and C native eggs (P<0.05); the content of C22:6n3 in yolk of ordinary eggs was significantly higher than that of brand A native eggs (P<0.05); there was no significant difference in ω-6/ω-3 PUFA ratio of yolk of ordinary eggs and native eggs of three brands (P>0.05). The study provides theoretical and practical reference for customers for selection of eggs.

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GSK-3β promotes PA-induced apoptosis through changing β-arrestin 2 nucleus location in H9c2 cardiomyocytes

Cited by 5 publications

References 33 publications

β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer

β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer

Zearalenone-Promoted Follicle Growth through Modulation of Wnt-1/β-Catenin Signaling Pathway and Expression of Estrogen Receptor Genes in Ovaries of Postweaning Piglets

A Comparative Study of Fatty Acid Content in Yolk of Native Eggs and Ordinary Eggs Available in the Market

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