Autoimmune/Inflammatory Arthritis Associated Lymphomas: Who Is at Risk?

Yadlapati, Sujani; Efthimiou, Petros

doi:10.1155/2016/8631061

Cited by 27 publications

(22 citation statements)

References 103 publications

(86 reference statements)

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“…The etiology of RA is unclear. Previous studies suggest that RA is associated with genetic factors, infection, immunity and endocrine function (6,7).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous previous studies have reported that inflammatory factors have an important role in the development of RA. Despite this, the etiology of this disease remains uncertain (6,12,13).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous previous studies have reported that inflammatory factors have an important role in the development of RA. Despite this, the etiology of this disease remains uncertain (6,12,13).Tripterygium is an ingredient in traditional Chinese medicine with anti-inflammatory effects that is sourced from Anhui, Zhejiang, Hunan, Guangxi, Guizhou, Yunnan and Sichuan provinces. (5R)-5-hydroxytriptolide (LLDT-8) is the extract of Tripterygium leaves, the main ingredients of which have a number of anti-inflammatory and immunoregulatory functions (14).…”

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confidence: 99%

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(5R)-5-hydroxytriptolide (LLDT-8) prevents collagen-induced arthritis through OPG/RANK/RANKL signaling in a rat model of rheumatoid arthritis

Zeng

Meng

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. (5R)-5-hydroxytriptolide (LLDT-8) extracts fromTripterygium have anti-inflammatory, antineoplastic and immunity adjustment functions. The present study used a collagen-induced arthritis (CIA) model to evaluate whether LLDT-8 prevents collagen-induced arthritis, and investigated the signaling underlying this. Male Sprague-Dawley rats were induced to generate CIA, mimicking rheumatoid arthritis (RA). The presence of arthritis was determined using RA progression scores. The inflammatory cytokines interleukin (IL)-1β, IL-6 and nuclear factor-κB were detected using enzyme-linked immunosorbent assay kits. Induced nitric oxide synthase (iNOS) and matrix metalloprotease (MMP)-13 protein expression were measured using western blot analysis. Lastly, reverse transcription-quantitative polymerase chain reaction was used to evaluate osteoprotegerin (OPG) and receptor activator of nuclear factor κB (RANK) gene expression. LLDT-8 improved RA progression scores and reduced the incidence and severity of CIA. Furthermore, LLDT-8 administration inhibited collagen-induced inflammation and iNOS protein expression in arthritic rats. The current data indicated that MMP-13 production was suppressed and OPG/RANKL expression was increased by LLDT-8 treatment in the arthritic rat. The present results suggest that LLDT-8 attenuates CIA through OPG/RANK/RANK ligand signaling in a rat model of RA. IntroductionRheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that is characterized by erosive arthrosynovitis (1).The incidence of RA in females is more than that in males, at a ratio of 1:3 (2). The mortality rate of RA in worldwide populations varies from 0.01-0.05%, and prevalence rate is 0.18-1.07% (3). RA is also an impactful disease, resulting in labor loss and disability in China (2). According to US epidemiological investigation over the last 40 years, the difference in mortality rate between RA patients and the general population has increased (4). The risk of cognitive impairment for RA patients is higher than that of the general population (5). The etiology of RA is unclear. Previous studies suggest that RA is associated with genetic factors, infection, immunity and endocrine function (6,7).The main pathological characteristics of RA are hyperplasia of synovial cells and T cell accumulation during inflammation of synovial tissues, accompanied by pannus formation, followed by damage to the cartilage and bone (8). Finally, RA causes joint deformity and functional loss (9). These pathological changes may result from a combination of genetic mutations, activation of protooncogenes, lesions of synoviocytes, release of proinflammatory cytokines by inflammatory cells during infiltration of synovial tissues, chemotactic factors and enzymatic degradation of stromal proteins, amongst other factors (10). The etiology of RA is unclear, but it is universally believed to be a multifactorial disease, associated with genetic, environmental and infective factors (11). Autoimmunity may arise due to genetic factors, or as an ab...

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“…The etiology of RA is unclear. Previous studies suggest that RA is associated with genetic factors, infection, immunity and endocrine function (6,7).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous previous studies have reported that inflammatory factors have an important role in the development of RA. Despite this, the etiology of this disease remains uncertain (6,12,13).…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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(5R)-5-hydroxytriptolide (LLDT-8) prevents collagen-induced arthritis through OPG/RANK/RANKL signaling in a rat model of rheumatoid arthritis

Zeng

Meng

et al. 2016

Experimental and Therapeutic Medicine

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“…The presence of rheumatoid factor and involvement of the wrists and hands should not lessen clinical suspicion, particularly in patients with risk factors for cancer. In fact, DLBCL is the commonest type of lymphoma associated with rheumatoid arthritis [ 12 , 13 ]. Other chronic inflammatory conditions have also been associated with increased risk of malignant lymphomas [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, DLBCL is the commonest type of lymphoma associated with rheumatoid arthritis [ 12 , 13 ]. Other chronic inflammatory conditions have also been associated with increased risk of malignant lymphomas [ 12 ]. But the association with paraneoplastic arthritis and DLBCL is not well known.…”

Section: Discussionmentioning

confidence: 99%

Migratory polyarthritis as a paraneoplastic syndrome in a patient with diffuse large B cell lymphoma: a case report

2018

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BackgroundDiffuse large B cell lymphoma is the commonest histological subtype of non-Hodgkin lymphoma and typically presents as a rapidly enlarging lymph node mass and B symptoms. It is unusual for diffuse large B cell lymphoma to present as carcinomatous polyarthritis which is a type of paraneoplastic arthritis.Case presentationWe present a case of a 45-year-old Asian man with diffuse large B cell lymphoma presenting with generalized lymphadenopathy, transient macular rash, and migratory polyarthritis involving both upper and lower limb small and large joints. Treatment of the lymphoma but not the routine anti-inflammatory agents resulted in complete resolution of the arthritis suggesting the paraneoplastic nature.ConclusionsPoor response to routine therapy for inflammatory arthritis should lead to early suspicion of paraneoplastic arthritis which will prompt investigation for an underlying malignancy. Suspicion of carcinomatous polyarthritis should be made in those with migratory polyarthritis and should be thoroughly investigated to exclude underlying malignancy.

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The Association of Autoimmune Disease With Lung Cancer Survival

Volkmann

2020

JAMA Netw Open

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A number of studies have demonstrated that patients with autoimmune and chronic inflammatory diseases are at heightened risk of the development of cancer, possibly due to factors such as aberrant immune function and surveillance, 1 focal organ damage, 2 and the use of immunomodulatory therapy. 3 For example, 1 large study 4 found that 13.5% of patients with lung cancer had an Author affiliations and article information are listed at the end of this article.

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Autoimmune/Inflammatory Arthritis Associated Lymphomas: Who Is at Risk?

Cited by 27 publications

References 103 publications

(5R)-5-hydroxytriptolide (LLDT-8) prevents collagen-induced arthritis through OPG/RANK/RANKL signaling in a rat model of rheumatoid arthritis

(5R)-5-hydroxytriptolide (LLDT-8) prevents collagen-induced arthritis through OPG/RANK/RANKL signaling in a rat model of rheumatoid arthritis

Migratory polyarthritis as a paraneoplastic syndrome in a patient with diffuse large B cell lymphoma: a case report

The Association of Autoimmune Disease With Lung Cancer Survival

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