Long-Term Follow-Up of Anterior Pituitary Deficiency after Aneurysmal Subarachnoid Hemorrhage: Prospective Cohort

Vieira, Gerival; Albuquerque, Lucas Alverne Freitas de; Avellar, Ariane Bernardes Camilo Castilho de; Pereira, Jorge Luís Gavina; Dellaretti, Marcos; Miranda, Paulo Augusto Carvalho; Macedo, Rodrigo Alvares Paiva; Silva, Laura Amaral Quintino da; Gusmão, Sebastião Nataniel Silva

doi:10.1016/j.jstrokecerebrovasdis.2016.06.011

Cited by 11 publications

(21 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conducted studies provide evidence for the prevalence of neuroendocrine dysfunction in SAH survivors, ranging from 0 to 55% [16]. A recently published study has shown that pituitary dysfunction as a late complication of SAH is present in 25% of patients [17]. Neuroendocrine disturbances may develop or improve in months, or even three years, after TBI and SAH.…”

Section: Introductionmentioning

confidence: 99%

Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population

Doknic

Pekić

Miljić

et al. 2017

International Journal of Endocrinology

View full text Add to dashboard Cite

There are only a few published studies related to the population-based etiology of hypopituitarism. New risks for developing hypopituitarism have been recognized in the last 10 years. Aim. To present data regarding the etiology of hypopituitarism collected in a tertiary center over the last decade. This is a cross-sectional database study. Patients and Methods. We included 512 patients (pts) with hypopituitarism, with a mean age of 45.9 ± 1.7 yrs (range: 18–82; male: 57.9%). Results. Nonfunctional pituitary adenomas were presented in 205 pts (40.5%), congenital causes in 74 pts (14.6%), while acromegaly and prolactinomas were presented in 37 (7.2%) and 36 (7.0%) patients, respectively. Craniopharyngiomas were detected in 30 pts (5.9%), and head trauma due to trauma brain injury-TBI and subarachnoid hemorrhage-SAH in 27 pts (5.4%). Survivors of hemorrhagic fever with renal syndrome (HFRS) and those with previous cranial irradiation were presented in the same frequency (18 pts, 3.5% each). Conclusion. The most common causes of hypopituitarism in our database are pituitary adenomas. Increased awareness of the other causes of pituitary dysfunction, such as congenital, head trauma, extrapituitary cranial irradiation, and infections, is the reason for a higher frequency of these etiologies of hypopituitarism in the presented database.

show abstract

Section: Introductionmentioning

confidence: 99%

Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population

Doknic

Pekić

Miljić

et al. 2017

International Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…The pathogenesis of aSAH [ 10 , 15 – 18 ] can also include traumatic brain injuries, genetic predisposition, and autoimmunity and neuroinflammatory responses. Insufficiencies in all pituitary hormones following SAH have been reported to differ from none to 68% in previous studies [ 5 , 11 , 17 , 19 ]. Our results revealed increased prolactin levels beginning 12 h after SAH.…”

Section: Discussionmentioning

confidence: 91%

“…Recent studies have also suggested that hypothalamic-pituitary insufficiency is very common following aSAH [ 3 – 5 ]. Hyperprolactinemia (HPRL) is physiological condition that occurs after intercourse and stressful activity, and during lactation and pregnancy.…”

Section: Introductionmentioning

confidence: 99%

High Prolactin Level as a Predictor of Vasospasm in Aneurysmal Subarachnoidal Hemorrhage

Çöven¹,

Kircelli

Duman

et al. 2017

Med Sci Monit

View full text Add to dashboard Cite

BackgroundAneurysmal subarachnoid hemorrhage (aSAH) is a destructive syndrome with a mortality rate of 50%. Recent studies have also suggested a high pervasiveness of hypothalamic-pituitary insufficiency in up to 45% of patients after aSAH. Prolactin has been associated with the pathogenesis of hypertensive irregularities that are linked to pregnancy.Material/MethodsWe identified a group of 141 patients with spontaneous SAH due to a ruptured cerebral aneurysm; these patients were operated on at our institution’s Neurosurgery and Interventional Radiology Department between 2011 and June 2015. All of the data were obtained retrospectively from medical records.ResultsThe hormonal abnormalities observed in the initial 24 h after ictus in subjects with subarachnoid SAH were caused by stressful stimulation aggravated by intracranial bleeding.ConclusionsThe elevated prolactin levels that occur in patients with aSAH can be used in conjunction with other auxiliary factors that we believe may be beneficial to vasospasm.

show abstract

“…In 34-36, 39, 42, 43, 45, 46] with a total of 705 participants evaluated the prevalence of Gn de ciency that was 0.33 (95% CI, 0.21-0.44, I 2 = 93.4%, P value <0.001). About hyperprolactinemia, the prevalence was 0.12 (95% CI, 0.07-0.16, I 2 = 69.3%, P value = 0.001) calculated by 12 studies [14,19,21,29,34,35,39,42,43,45,46] with a total of 621 participants. As shown in Table 3, it can be seen that the 95% con dence intervals of the prevalence of GHD or Gn de ciency and the remaining ACTH de ciency or hyperprolactinemia have no overlap respectively, so the prevalences of GHD or Gn de ciency were signi cantly higher than that of ACTH de ciency and hyperprolactinemia.…”

Section: Global Analysis For Pdmentioning

confidence: 97%

“…The included studies were published from 2004 and 2022, and the number of patients ranged from 20 to 417 per study, with a total of 1848 individuals. According to the zoning of the WHO Regional O ce, a total of 21 of these studies have focused on EURO[8,10,13,14,19,[21][22][23][29][30][31][32][33][34][35][36][37][38][39][40][41], the remaining 3 on SEARO [42][43][44], 2 on PAHO [45,46], and 1 on WPRO [47]. Of these studies, 22 articles had prospective study designs, and 5 were cross-sectional studies.…”

Section: Study Characteristicsmentioning

confidence: 99%

Prevalence of Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis

Song

Cong

Zhang

et al. 2022

Preprint

View full text Add to dashboard Cite

Background As a common complication after aneurysmal subarachnoid hemorrhage, the prevalence of pituitary dysfunction ranges widely at the global level and has not been synthesized by meta-analysis for a few years. Updated estimates of the prevalence of pituitary dysfunction after aneurysmal subarachnoid hemorrhage are urgently needed to improve recognition and attention from medical. Methods We comprehensively searched four literature databases including Scopus, Embase, Web of Science and PubMed, and performed a random-effects meta-analysis for the search results. Heterogeneity in the prevalence estimates was analyzed by subgroup analysis in terms of WHO region and type of pituitary dysfunction. Results 27 studies with 1848 subjects were included in this study. The pooled prevalence of pituitary dysfunction in the acute phase was 49.6% (95% CI, 32.4%-66.8%), and decreased in the chronic phase to 30.4% (95% CI, 21.4%-39.4%). Among the hormonal deficiencies, growth hormone dysfunction was the most prevalent in the acute phase with 36.0% (95% CI, 21.0%-51.0%), and in the chronic phase was hypoadrenalism accounting for 21.0% (95% CI, 12.0%-29.0%). While referring to the WHO region, the prevalence of pituitary dysfunction in the acute phase was the highest in SEARO, up to 81.0% (95%CI, 77.0%-86.0%), while the EURO with the highest prevalence of pituitary dysfunction in the chronic phase, was only 33.0% (95%CI, 24.0%-43.0%). Moreover, single pituitary hormone dysfunction occurred more frequently than that of multiple regardless of in the acute or chronic phase. Conclusions In up to 49.6%, patients with aneurysmal subarachnoid hemorrhage may be complicated with pituitary dysfunction, which deserved more attention. Although the prevalence decreased over time, early detection and early treatment were more beneficial for the quality of life of patients. However, the number of existing studies on PD after aSAH is limited. Therefore, more studies based on larger populations and countries are necessary to provide early warning.

show abstract

Long-Term Follow-Up of Anterior Pituitary Deficiency after Aneurysmal Subarachnoid Hemorrhage: Prospective Cohort

Cited by 11 publications

References 29 publications

Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population

Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population

High Prolactin Level as a Predictor of Vasospasm in Aneurysmal Subarachnoidal Hemorrhage

Prevalence of Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis

Contact Info

Product

Resources

About