Proteomics ofPlasmodium vivaxmalaria: new insights, progress and potential

Abstract

This review briefly describes the epidemiology of vivax malaria, analyzes challenges towards effective control and summarizes major insights provided by genomics and transcriptomics research in the area. Subsequently, the review provides a detailed description of the applications of proteomics in vivax malaria research, focusing on both host responses and parasite proteomics studies to understand P. vivax biology. Expert commentary: In recent years, proteomics technologies are being used effectively to understand P. vivax biology and the underlying pathogenesis. Technological advances in mass spectrometry configurations, multiomics investigations and emerging strategies such as targeted proteomics may also immensely aid in studying disease severity, improving existing diagnosis and identifying new drug and vaccine targets.

Receptor-ligand and parasite protein-protein interactions inPlasmodium vivax: Analysing rhoptry neck proteins 2 and 4

“…Such limitations have been a barrier to studying the biological, clinical, and immunological characteristics necessary for designing control measures against P. vivax . Using P. vivax strains adapted in non‐human primates (Pico de Coana et al, ) or infected patients' blood (Bozdech et al, ) has enabled comparative approaches with other Plasmodium species (Patarroyo, Calderon, & Moreno‐Perez, ) or using omic sciences (Moreno‐Perez, Degano, Ibarrola, Muro, & Patarroyo, ; Venkatesh et al, ) to identify a significant amount of proteins expressed in P. vivax schizonts (Sch) and Mz (Patarroyo et al, ). Pv RON2 (Arevalo‐Pinzon, Curtidor, Patino, & Patarroyo, ), Pv RON4 (Arevalo‐Pinzon, Curtidor, Abril, & Patarroyo, ), and Pv RON5 (Arevalo‐Pinzon, Bermudez, Curtidor, & Patarroyo, ) have been identified recently; these are homologous to those identified in P. falciparum , which are located in the apical extreme of P. vivax Colombia Guaviare 1 (VCG‐1) strain Sch.…”

Multiplexed quantitative proteomics provides mechanistic cues for malaria severity and complexity

“…Intriguingly, several studies from our and other research groups have defined promising panels of plasma and serum markers in falciparum [19][20][21][22][23][24] and vivax 19,25,26 malaria. A considerable amount of further research is required to understand the complex pathophysiology of severe malaria [27][28][29] . In particular, the blood markers that can effectively define different complications of severe malaria are not clearly demarcated hitherto.…”

Malaria in India: The Need for New Targets for Diagnosis and Detection of Plasmodium vivax

“…Reviews summarizing the recent proteomics studies that have been performed for P. vivax are available in the literature, therefore, in this section, we position these proteomics studies in the context of the gaps in P. vivax diagnosis. Here we discuss the contributions of classical proteomics techniques, extensions of these techniques such as protein microarrays, and a few studies on metabolomics.…”