Incidence of malignancies in patients with juvenile idiopathic arthritis: A retrospective single-center cohort study in Germany

Administration of anti-TNFα agents has become a mainstay in the treatment of chronic inflammatory arthritis such as rheumatoid arthritis (RA) and spondyloarthritis. Adverse events, including infections and allergic reactions, have been reported. Malignancies are rare but potentially life threatening. The existence of bone tumor in those patients is very rare, only five cases of bone tumors were mentioned in juvenile idiopathic arthritis (JIA) in the literature. We describe three patients in whom bone neoplasms developed after years of anti-TNFα therapy for JIA or juvenile ankylosing spondylitis (JAS). One patient developed chondroblastoma, and the other two were diagnosed with osteosarcoma. Rheumatologists should increase their awareness of bone neoplasia in JIA or juvenile ankylosing spondylitis patients after anti-TNFα treatment.

show abstract

Incidence of malignancies in patients with juvenile idiopathic arthritis: A retrospective single-center cohort study in Germany

Abstract: Although no overall increased cancer risk was found, results suggest that the risk of melanoma might be increased in female JIA patients.

Cited by 3 publications

References 20 publications

Temporomandibular joint diseases

Temporomandibular joint diseases

Juvenile Idiopathic Arthritis

Bone Tumors Developed in Patients with Juvenile Inflammatory Arthritis after Anti-Tnfα Therapy

Contact Info

Product

Resources

About