Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk

Duval, Manuel; Cossart, Pascale; Lebreton, Alice

doi:10.1016/j.semcdb.2016.06.016

Cited by 74 publications

(66 citation statements)

References 109 publications

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“…Several lines of evidence demonstrated the pivotal role of this molecular process as the major antiviral response at cellular and systemic level, against both natural and unnatural D. melanogaster viruses (23)(24)(25)(26)(27)(28). Nevertheless, we still have a scarce comprehension of the biological implication of the siRNA pathway in gene regulation (11) and in trans-kingdom communication (29)(30)(31). A comprehensive understanding of the regulation of the siRNA-mediated response upon different biotic and abiotic stimuli, from virus infection and cellular stress to environmental cues, could shed light on the global role that this pathway plays in the organism.…”

Section: Discussionmentioning

confidence: 99%

Viral Infection and Stress Affect Protein Levels of Dicer 2 and Argonaute 2 in Drosophila melanogaster

et al. 2020

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The small interfering RNA (siRNA) pathway of Drosophila melanogaster, mainly characterized by the activity of the enzymes Dicer 2 (Dcr-2) and Argonaute 2 (Ago-2), has been described as the major antiviral immune response. Several lines of evidence demonstrated its pivotal role in conferring resistance against viral infections at cellular and systemic level. However, only few studies have addressed the regulation and induction of this system upon infection and knowledge on stability and turnover of the siRNA pathway core components transcripts and proteins remains scarce. In the current work, we explore whether the siRNA pathway is regulated following viral infection in D. melanogaster. After infecting different fly strains with two different viruses and modes of infection, we observed changes in Dcr-2 and Ago-2 protein concentrations that were not related with changes in gene expression. This response was observed either upon viral infection or upon stress-related experimental procedure, indicating a bivalent function of the siRNA system operating as a general gene regulation rather than a specific antiviral system.

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Section: Discussionmentioning

confidence: 99%

Viral Infection and Stress Affect Protein Levels of Dicer 2 and Argonaute 2 in Drosophila melanogaster

et al. 2020

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“…For example, the expression of noncoding RNAs in host cells responds to cues of infection and inflammation, and contributes to regulate multiple immune-related genes. Intriguingly, noncoding RNA expression partly depends on the specific pathogen infecting the host (Duval et al 2017;zur Bruegge et al 2017). Unsurprisingly, host RNAs are themselves targeted by parasites because of their immunoregulatory activity (Duval et al 2017;zur Bruegge et al 2017).…”

Section: Reactive Robustnessmentioning

confidence: 99%

“…Intriguingly, noncoding RNA expression partly depends on the specific pathogen infecting the host (Duval et al 2017;zur Bruegge et al 2017). Unsurprisingly, host RNAs are themselves targeted by parasites because of their immunoregulatory activity (Duval et al 2017;zur Bruegge et al 2017). Some of these RNA molecules may interfere with the messenger and noncoding RNAs injected by the parasite, initiate epigenetic changes that counteract their activity, or even regulate the expression of the parasite's own genes.…”

Section: Reactive Robustnessmentioning

confidence: 99%

Invisible Designers: Brain Evolution Through the Lens of Parasite Manipulation

Giudice¹

2019

The Quarterly Review of Biology

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keywords behavior, brain evolution, hormones, neurobiology, parasite-host interactions, parasite manipulation abstract The ability of parasites to manipulate host behavior to their advantage has been studied extensively, but the impact of parasite manipulation on the evolution of neural and endocrine mechanisms has remained virtually unexplored. If selection for countermeasures has shaped the evolution of nervous systems, many aspects of neural functioning are likely to remain poorly understood until parasites-the brain's invisible designers-are included in the picture. This article offers the first systematic discussion of brain evolution in light of parasite manipulation. After reviewing the strategies and mechanisms employed by parasites, the paper presents a taxonomy of host countermeasures with four main categories, namely: restrict access to the brain; increase the costs of manipulation; increase the complexity of signals; and increase robustness. For each category, possible examples of countermeasures are explored, and the likely evolutionary responses by parasites are considered. The article then discusses the metabolic, computational, and ecological constraints that limit the evolution of countermeasures. The final sections offer suggestions for future research and consider some implications for basic neuroscience and psychopharmacology. The paper aims to present a novel perspective on brain evolution, chart a provisional way forward, and stimulate research across the relevant disciplines.

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“…Depending on the type of glycans (ABO) the creation of the lipid raft will change slightly in architecture [155], allowing certain proteins to become closer and thus be able to recognize foreign matter differentially. direct post-transcriptional repression, are predicted to regulate up to 60% of human protein-coding genes [202,203]. The mechanism of action involves Being similar to methylation, miR are involved in epigenetic regulation of protein synthesis [172].…”

Section: Mirna Are Ubiquitously Small and Reactivementioning

confidence: 99%

“…It has been shown that IEC's miRNAs are absorbed by the microbiota [413] and modulate the gene transcripts affecting bacterial growth [414]. This is part of the complex regulatory networks of host pathogen interaction [202]. Exosomal miRNAs are released for the regulation of bacterial gene expression [415].…”

Section: Gut-microbiome-diet Interactionmentioning

confidence: 99%

Recent Advances In Nutritional Sciences: An Overview Of Glycans And MiRNAs

Menapace¹

2018

J Nutr Food Sci

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There are many nutritional substances that humans consume on a daily basis: water, carbohydrates lipids and proteins are main biochemical components of food. But others in a smaller amount are vitamins minerals and enzymes. At a possibly lesser quantity are glycans and miRNAs. The presence of oligoglycans in all food sources has been an established fact for many years. These special carbohydrates are present as glycoconjugates (glycoproteins or glycolipids) in and on the surface of all the cells (glycocalyx) of all organisms that we eat and remain intact through the GI tract as we lack the enzymatic repertoire of the human body to unbind their particular β-linkages. Glycans bind to naturally present human lectins (through protein-carbohydrate interactions), but also with other human glycans (through carbohydrate-carbohydrate interactions, or CCI). Moreover, these glycans, like fibres, are digested by the gut microbiota that resides within the intestine. As our biochemistry shapes the composition of the microbiome, so does the composition of glycans and foods that we consume, triggering biological responses. miRNAs are small, single-stranded, 19-to 23-nucleotide-long RNA molecules and affect the stability of messenger RNA (mRNA) influencing protein synthesis. miRNAs are also present in foods and act on both the microbial composition in our gut and may be absorbed by the walls of the GI tract, demonstrating resistance to food processing and enzymatic attack. Though still a topic of controversy, these small, noncoding RNAs that control gene expression may directly enter into the circulating miRNA population of dietary exogenous miRNAs. It can hence be possible to identify a relationship between glycans and miRNAs in food on one side, microbiota composition on the other and the resultant health status of the host (immune system), on the third side.

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Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk

Cited by 74 publications

References 109 publications

Viral Infection and Stress Affect Protein Levels of Dicer 2 and Argonaute 2 in Drosophila melanogaster

Viral Infection and Stress Affect Protein Levels of Dicer 2 and Argonaute 2 in Drosophila melanogaster

Invisible Designers: Brain Evolution Through the Lens of Parasite Manipulation

Recent Advances In Nutritional Sciences: An Overview Of Glycans And MiRNAs

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