Ninety-five orthotopic transplantations in 74 women of ovarian tissue after cytotoxic treatment in a fertility preservation network: tissue activity, pregnancy and delivery rates

H, van der Ven; Liebenthron, Jana; Beckmann, MW; Tóth, Bettina; Korell, M.; Krüssel, Jan-Steffen; Frambach, Torsten; Kupka, M.; Mk, Hohl; Winkler-Crepaz, Katharina; Seitz, S; Doğan, Aşkın; Griesinger, G.; Häberlin, Felix; Henes, Melanie; Schwab, Roxana; Sütterlin, Marc; M, von Wolff; Dittrich, Ralf

doi:10.1093/humrep/dew165

Cited by 278 publications

(207 citation statements)

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“…An overview of the perinatal outcome of children conceived in women who have had frozen-thawed ovarian tissue transplanted available from peer-reviewed papers, including nine new Danish cases, is given in Tables 2 [13,, 3, and 4. Table 2 provides detailed information on the deliveries from published peer-reviewed journals including information on the woman (diagnosis, age at cryopreservation and signs of menopause before transplantation, time from transplantation Oktay et al [13] S F N A 1 Meirow et al [14] SF NA* 4 (+2) The Nordic countries [15] and this publication SF (Sweden VF) 14 7(+2)** FertiPROTEKT network [16] SF 54*** 11 Dunlop et al [17] S F N A 1…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, they do not figure in this table **Additionally one ongoing Danish pregnancy, which had not been registered at the time of publication. This woman has now given birth and is described as the second child of case 1 in this publication ***Van der Ven and co-workers [16] have evaluated 74 women, and within these 74 women are the 20 women Dittrich and co-workers [11] have already published. Therefore, to avoid any duplicates, it is 54 new cases with 11 new births Table 3 provides similar detailed information on the nine new Danish children (case no.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children

Jensen

Macklon²,

Fedder

et al. 2016

J Assist Reprod Genet

247

160

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Purpose This study aims to make an account of the children born following transplantation of frozen-thawed ovarian tissue worldwide with specific focus on the perinatal outcome of the children. Furthermore, perinatal outcome of seven deliveries (nine children) from Denmark is reported. Methods PubMed was searched for papers of deliveries resulting from ovarian tissue cryopreservation (OTC). Seven women underwent OTC prior to chemotherapy. Four of these women still had low ovarian function and had tried to conceive. They therefore had tissue autotransplanted to augment their fertility. The other three women had developed premature ovarian insufficiency (POI) after the end of treatment.Results Worldwide, approximately 95 children have been born or will be born in the near future from OTC, including these 9 new children. Information on the perinatal outcome was found on 40 children. The mean gestational age was 39 weeks and the mean birth weight was 3168 g of the singleton pregnancies, which is within internationally recognized normal standards. Furthermore, half the singletons resulted from natural conception and all twins resulted from in vitro fertilization treatment. All seven Danish women became pregnant within 1-3 years after transplantation. They gave birth to nine healthy children. Conclusion The data is reassuring and further suggests that cryopreservation of ovarian tissue is becoming an established fertility preservation method. The seven Danish women reported in this study were all in their early thirties when OTC was performed. Most other reported cases were in the women's twenties. This suggests that the follicular pool in the thirties is large enough and sufficient to sustain fertility.Keywords Fertility preservation . Cryopreservation . Ovarian tissue transplantation . Deliveries IntroductionOvarian tissue cryopreservation (OTC) and transplantation is a relatively new procedure within the area of assisted reproduction technologies (ART). OTC differs from other ART procedures like freezing oocytes or embryos by cryopreserving intact tissue containing small non-growing follicles [1,2]. Although the cryoprotectant media used to freeze ovarian tissue resemble those media used for oocytes and embryos, there are often subtle differences [3,4]. Furthermore, extensive investigations on the effects of cryoprotectants on both human and animal ovarian tissue have not revealed any potential side effects. However, studies in women who had frozen-thawed ovarian tissue transplanted have The original version of this article was revised: There were errors in the Discussion section and the last paragraph should be removed.Capsule The data is reassuring and further suggests that cryopreservation of ovarian tissue is becoming an established fertility preservation method.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children

Jensen

Macklon²,

Fedder

et al. 2016

J Assist Reprod Genet

247

160

View full text Add to dashboard Cite

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“…An example is FertiPROTEKT, a network of fertility preservation programs in Germany, Switzerland, and Austria [26]. …”

Section: How To Cryopreserve Human Ovarian Tissuementioning

confidence: 99%

Cryopreservation of Human Ovarian Tissue: A Review

Leonel

Lucci

Amorim

2019

Transfus Med Hemother

117

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Background: Cryopreservation of human ovarian tissue has been increasingly applied worldwide to safeguard fertility in cancer patients, notably in young girls and women who cannot delay the onset of their treatment. Moreover, it has been proposed to patients with benign pathologies with a risk of premature ovarian insufficiency. So far, more than 130 live births have been reported after transplantation of cryopreserved ovarian tissue, and almost all patients recovered their ovarian function after tissue reimplantation. Summary: This review aims to summarize the recent results described in the literature regarding human ovarian tissue cryopreservation in terms of methods and main results obtained so far. To cryopreserve human ovarian tissue, most studies describe a slow freezing/rapid thawing protocol, which is usually an adaptation of a protocol developed for sheep ovarian tissue. Since freezing has been shown to have a deleterious effect on ovarian stroma and granulosa cells, various research groups have been vitrifying ovarian tissue. Despite promising results, only 2 babies have been born after transplantation of vitrified/warmed ovarian tissue. Optimization of both cryopreservation strategies as well as thawing/warming protocols is therefore necessary to improve the survival of follicles in cryopreserved ovarian tissue. Key Messages: Human ovarian tissue cryopreservation has been successfully applied worldwide to preserve fertility in patients with malignant or nonmalignant pathologies that have a detrimental effect on fertility. Human ovarian tissue cryopreservation could also be applied as an alternative to postpone pregnancy or menopause in healthy women. Slow freezing and vitrification procedures have been applied to cryopreserve human ovarian tissue, but both alternatives require optimization.

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“…The technique is still considered as experimental, but almost 100 babies were born worldwide after ovarian tissue transplantation at an orthotopic site, and live birth rates have been estimated around 30% 56,57 The low access to fertility preserving procedures in Latin America is also explained by the fact that these options are not covered either by the governments or by private health insurers 64 . This represents a direct and often unreachable out of pocket expense for patients, particularly in limited resource settings with income inequities.…”

Section: Cryopreservation Of Ovarian Tissuementioning

confidence: 99%

Viable Options for Fertility Preservation in Breast Cancer Patients: A Focus on Latin America

Lambertini

Goldrat

Barragán-Carrillo

et al. 2017

RIC

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Thanks to the improved survival outcomes observed in recent years, a growing attention has been given to the quality of life issues faced by young women with breast cancer such as fertility preservation and concerns related to future pregnancies.However, several challenges remain for young women with breast cancer considering undergoing fertility preservation strategies.Further specific issues on this regard should be taken into account in Latin America, where patients and physicians face particular barriers that hinder the routine adoption of this practice. Hence, further efforts are needed to overcome these deficiencies and improve the correct referral of breast cancer patients to fertility preservation strategies.The aim of the present review is to focus on the risk of anticancer treatment-related premature ovarian failure and infertility in young breast cancer patients, to summarize the current knowledge on the available options for fertility preservation, and to discuss the safety issues of pregnancy in breast cancer survivors. Furthermore, this review aims to highlight the specific clinical challenges in this field encountered by healthcare providers and young breast cancer patients from Latin American countries. (REV INVES CLIN. 2017;69:103-13)

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Ninety-five orthotopic transplantations in 74 women of ovarian tissue after cytotoxic treatment in a fertility preservation network: tissue activity, pregnancy and delivery rates

Abstract: None.

Cited by 278 publications

References 27 publications

86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children

86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children

Cryopreservation of Human Ovarian Tissue: A Review

Viable Options for Fertility Preservation in Breast Cancer Patients: A Focus on Latin America

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