Frequency of diabetic retinopathy and related factors in patients with diabetes having coronary artery disease

Ohtomo, Kazuyoshi; Shigeeda, Takashi; Hirose, Akira; Ohno, Takayuki; Katoh, Osamu; Fujita, Hideo; Ando, Jiro; Nagai, Ryozo; Takamoto, Shinichi; Kadowaki, Takashi; Kato, Satoshi

doi:10.1016/j.diabres.2016.06.016

Cited by 4 publications

(4 citation statements)

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“…N -acetylneuraminic acid was associated with myocardial infarction 19 . Given that there were associations between cardiovascular complications and retinal 8 , 20 or renal 7 complication of persons with T2D, N -acetylneuraminic acid could contribute to the shared etiology among the cardiovascular, retinal, and renal complications of persons with T2D. Myocardial infarction model rats which were knocked down Neuraminidase1, an N -acetylneuraminic acid-producing enzyme, showed reduced myocardial damage compared to the control rats due to the reduced accumulation of the inflammatory cells to the ischemic site 21 .…”

Section: Discussionmentioning

confidence: 99%

Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes

et al. 2023

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Background Type 2 diabetes is a common disease around the world and its major complications are diabetic retinopathy (DR) and diabetic kidney disease (DKD). Persons with type 2 diabetes with complications, especially who have both DR and DKD, have poorer prognoses than those without complications. Therefore, prevention and early identification of the complications of type 2 diabetes are necessary to improve the prognosis of persons with type 2 diabetes. The aim of this study is to identify factors associated with the development of multiple complications of type 2 diabetes. Methods We profiled serum metabolites of persons with type 2 diabetes with both DR and DKD (N = 141) and without complications (N = 159) using a comprehensive non-targeted metabolomics approach with mass spectrometry. Based on the serum metabolite profiles, case–control comparisons and metabolite set enrichment analysis (MSEA) were performed. Results Here we show that five metabolites (cyclohexylamine, P = 4.5 × 10−6; 1,2-distearoyl-glycero-3-phosphocholine, P = 7.3 × 10−6; piperidine, P = 4.8 × 10−4; N-acetylneuraminic acid, P = 5.1 × 10−4; stearoyl ethanolamide, P = 6.8 × 10−4) are significantly increased in those with the complications. MSEA identifies fatty acid biosynthesis as the type 2 diabetes complications-associated biological pathway (P = 0.0020). Conclusions Our metabolome analysis identifies the serum metabolite features of the persons with type 2 diabetes with multiple complications, which could potentially be used as biomarkers.

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Section: Discussionmentioning

confidence: 99%

Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes

et al. 2023

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“…In another study forty percent diabetic patient with CAD had DR as well, which was confirmed by non-mydriatic fundus images. 31 In a study conducted by Raj BK et al 32 , they had mentioned that the presence of microvascular diabetic complications was more with nephropathy then with retinopathy (62 vs 58%). Neuropathy was not documented.…”

Section: Discussionmentioning

confidence: 97%

“…In another study forty percent diabetic patient with CAD had DR as well, which was confirmed by non-mydriatic fundus images. 31 The idea of doing this study came to us after carefully reviewing the literature where we found that still little evidence is available regarding frequency of diabetic retinopathy in patients of acute ST elevated MI in our population. We want to determine the frequency of diabetic retinopathy in patients of acute ST elevated MI in our population in this study.…”

Section: Introductionmentioning

confidence: 99%

Frequency of diabetic retinopathy in patients of acute ST elevated myocardial infarction (STEMI).

Sanaullah¹,

Shah²,

Khan³

et al. 2021

TPMJ

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Objective: To determine the frequency of diabetic retinopathy in patients of acute ST elevated Myocardial Infarction (STEMI) in our population. Study Design: Cross Sectional study. Setting: Department of Cardiology, Lady Reading Hospital, Peshawar. Period: 20th November 2018 to 19th May 2019. Material & Methods: Detailed history was taken and previous records were reviewed to look for diagnosis of DM, followed by complete examination and investigations including FBC, LFTs, RFTs, ECG and echo to fulfill exclusion criteria. Fundoscopy was performed by two experienced cardiology trainees with riester ophthalmoscope. Consensus was made on ophthalmoscopy findings regarding the presence or absence of Diabetic Retinopathy (DR). Results: In this study a total of 189 patients were observed. Mean age was 43 years with SD ±11.23. Sixty six percent patients were male while 34% patients were female. More over 5% patients had diabetic retinopathy while 95% patients did not have diabetic retinopathy. Conclusion: Our study concludes that the frequency of diabetic retinopathy was 5% in patients of acute ST elevated MI in our population.

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“…Most studies have been small with patient numbers ranging from 69-371 subjects in diabetic patients to 437 subjects in hypertensive subjects. In one study the prevalence of DR in diabetic CAD patients was found to be 39% in 90 subjects (88). Two hundred and twenty-three diabetics with multivessel CAD were followed up for eleven years after undergoing coronary artery bypass graft (CABG).…”

Section: E Diabetic-and Hypertensive Retinopathy Related Morbiditymentioning

confidence: 99%

The prevalence and severity of retinopathy in patients with coronary artery disease at a tertiary hospital in Durban, South Africa.

de Jager

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Sr Asmal and her eye clinic staff: for their willingness and assistance to establish appropriate time for research, putting forth ideas regarding safely transporting and caring for cardiology patients at the eye clinic, and helping with visual acuity measurements and dilating patients' pupils.2. Nursing staff at the cardiology wards and ICU: for organizing safe transport of patients to the eye clinic where applicable.3. The cardiology administrative assistant, Cairan: for her weekly updates on coronary angiogram admission lists to the cardiology ward.4. IALCH porters: for assisting with transfer of patients to the eye clinic and back to their respective wards.5. Rajeshree Budhoo: Optometrist at the IALCH eye clinic: for assistance with the OCT measurements and taking of fundus photos. 6. Dr S Baboolal, Consultant in Ophthalmology: for her insight into the time and effort needed to write up the MMed and highlighting the importance of finding the correct and appropriate target journal. vi List of Abbreviations and Acronyms ACCESS -Acute Coronary Events -a multinational Survey of current management Strategies ACCF -American College of Cardiology Foundation AHA -American Heart Association ACS -Acute coronary syndrome ASRD -age-standardized related death ARIC -Atherosclerosis risk in community BRVO -branch retinal vein occlusion CABG -Coronary artery bypass graft CAD -Coronary artery disease CKD -Chronic kidney disease CMT -Central macular thickness CRIC -chronic renal insufficiency cohort CSA -Chronic stable angina CSMO -Clinically significant macular oedema CVD -Cardiovascular disease DR -Diabetic retinopathy DVD -Double vessel disease ETDRS -Early treatment in diabetic retinopathy study ETODH -Evaluation of target organ damage in hypertension FAZ -Foveal avascular zone GCL -Ganglion cell layer Hb -Haemoglobin HDL -High density lipoprotein HR -Hypertensive retinopathy IALCH -Inkosi Albert Luthuli Central Hospital ICU -Intensive care unit IRMA -Intra-retinal microvascular abnormalities LDL -Low density lipoprotein

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Frequency of diabetic retinopathy and related factors in patients with diabetes having coronary artery disease

Cited by 4 publications

References 4 publications

Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes

Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes

Frequency of diabetic retinopathy in patients of acute ST elevated myocardial infarction (STEMI).

The prevalence and severity of retinopathy in patients with coronary artery disease at a tertiary hospital in Durban, South Africa.

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