Acitretin and aloe-emodin loaded chitin nanogel for the treatment of psoriasis

Divya, G.; Panonnummal, Rajitha; Gupta, Swati; Jayakumar, R.; Sabitha, M.

doi:10.1016/j.ejpb.2016.06.019

Cited by 92 publications

(59 citation statements)

References 48 publications

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“…In the present study, different concentrations of optimized formulation F1 were tested and showed no evidence of haemolysis (<0.5%) after incubation for specified time period. 25,26 All the concentrations of F1 meet the standard, the data confirmed the optimized formulation F1 provides an acceptable level of haemolysis as shown in Figure 5.…”

Section: Resultssupporting

confidence: 61%

Enhanced Lymphatic Uptake of Leflunomide Loaded Nanolipid Carrier via Chylomicron Formation for the Treatment of Rheumatoid Arthritis

Krishnan¹,

Mukundan²,

Suresh³

et al. 2018

Adv Pharm Bull

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Purpose: The current study aims the lymphatic delivery of leflunomide loaded nanostructured lipid carriers (LNLC) for the treatment of rheumatoid arthritis, mainly focussed to enhance the lymphatic delivery via chylomicron formation, improved bioavailability and reduced systemic toxicity.Methods: Melt emulsification ultra-sonication method was used to formulate the nanostructured lipid carrier (NLC) containing leflunomide. Four batches were prepared by using various concentration of surfactants (tween 80 and poloxmer 188) and lipid mixtures (stearic acid and oleic acid). All the formulations were studied for various physiochemical propertiesResults: The formulation with increased concentration of lipid and surfactants showed highest entrapment efficiency (93.96 ± 0.47%) and better drug release (90.35%) at the end of 48 hrs. In vivo tests were carried out to determine the antiarthritic potential of the formulation in Sprague-dawley rats for a duration of 30d. The effect was evaluated by measuring the reduction in knee thickness. LNLC showed a marked reduction in inflammation compared to standard drug. Intestinal lymphatic uptake studies of LNLC were performed by intraduodenal administration and compared with leflunomide drug solution. The mesenteric lymph node was analysed by HPLC method and the concentration of drug was estimated. It showed that LNLC having highest uptake (40.34μg/ml) when compared with leflunomide drug solution (10.04μg/ml). Radiographic analysis and histopathological studies showed the formation of healthy cartilage after treatment period.Conclusion: The results suggested that LNLC has the potential to reduce the systemic toxicities associated with conventional therapy along with improved efficacy in the treatment of rheumatoid arthritis.

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Section: Resultssupporting

confidence: 61%

Enhanced Lymphatic Uptake of Leflunomide Loaded Nanolipid Carrier via Chylomicron Formation for the Treatment of Rheumatoid Arthritis

Krishnan¹,

Mukundan²,

Suresh³

et al. 2018

Adv Pharm Bull

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“…[86][87][88][89] Regarding L929 cells, the viability was reduced for both free Act and Act-loaded niosomes in a concentration-dependent manner; however, a relative improvement in cell viability of the drug was achieved after loading in niosomal vesicles ( Figure 7A). These outcomes were in accordance with the cytotoxicity data published by Divya et al 36 for Act, either free or entrapped in chitin nanogel. On the other hand, a specific cytotoxicity of the drug was recorded toward the highly proliferative HaCaT cells (IC 50 =15.352±0.387 μg/mL), which was further augmented after encapsulation in the nano niosomal carrier (IC 50 =3.448±0.383 μg/mL; Figure 7B).…”

Section: Kinetic Analysis Of Release Datasupporting

confidence: 92%

“…The hydroalcoholic solution (1:1 v/v), as a receptor medium, was used to allow quantitative determination of Act because of its poor aqueous solubility (0.0729 mg/L). 36 The niosomal formulation or the drug suspended in propylene glycol was placed on the skin in the donor half-cell which was sealed with parafilm. To hinder exposure to light, the cell was covered with aluminum foil.…”

Section: Ex Vivo Skin Permeation Study For Different Niosomal Formulamentioning

confidence: 99%

“…Analogus findings were experienced by other researchers who demonstrated the pivotal role of niosomal gel in improving the topical delivery of adapalene (third-generation topical retinoid) and capsaicin with a concomitant reduction of their irritation effect. 70,103 Previously, Agrawal et al 35 and Divya et al 36 correlated the reduction of Act skin irritation to its encapsulation in nanostructured lipid carriers and chitin nanogel, respectively. Therefore, Act niosomal gel could be considered as a promising formula in improving the skin tolerability and investigate the in vivo antipsoriatic activity of different gel formulations.…”

Section: Histopathologic Examinationmentioning

confidence: 99%

“…[31][32][33] To address these tremendous problems, a few endeavors have been targeted toward the development of topical delivery systems for Act through complexation with cyclodextrin, 34 and encapsulation in nanostructured lipid carriers 35 or chitin nanogel. 36 Accordingly, this context encouraged us to devote this work to extensive ex vivo-in vivo investigations of Act nanovesicular gel in order to explore its pivotal role as a topical delivery system for effective treatment of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

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Pivotal role of Acitretin nanovesicular gel for effective treatment of psoriasis: ex vivo–in vivo evaluation study

Hashim

El-Magd

El‐Sheakh

et al. 2018

IJN

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The goal of the current study was to explore the potential benefits of Acitretin (Act) nanovesicular gel as a prospective antipsoriatic topical delivery system counteracting the drug challenges in terms of its extremely low aqueous solubility, instability, skin irritation, and serious systemic adverse effects. Act-loaded niosomes were successfully developed, entirely characterized, and optimized. Further evaluation of the optimized formula was conducted regarding its stability and ex vivo cytotoxicity on different cell lines. The optimized niosomal vesicles were then incorporated in gel base matrix and investigated by sequential ex vivo (skin permeation and deposition) and in vivo (skin irritation and antipsoriatic activity using mouse tail model) experiments. The optimized Act-loaded niosomes (span 60:cholesterol molar ratio 1:1) were spherical in shape and exhibited the highest entrapment efficiency (90.32±3.80%) with appropriate nanosize and zeta potential of 369.73±45.45 nm and −36.33±1.80 mV, respectively. Encapsulation of the drug in the nanovesicles was further emphasized by differential scanning calorimetric and powder X-ray diffraction studies. After 3 months storage at 4±1°C, the optimized formula preserved its stability. Act nano niosomal gel produced a remarkable enhanced ex vivo permeation profile up to 30 h and significant drug deposition in the viable epidermal–dermal layers compared with those of Act gel. The pronounced antipsoriatic activity of the medicated nano niosomes was proved ex vivo in HaCaT cells (a keratinocyte cell line). Topical application of Act nano niosomal gel to mouse tail model further established its distinct in vivo antipsoriatic superiority in terms of significantly higher orthokeratosis, drug activity, and reduction in epidermal thickness compared with the control and other gel formulations. Also, negligible skin irritation and better skin tolerability of Act nanovesicular gel were revealed by primary irritation index and histopathologic examination.

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Translating Therapeutic Microgels into Clinical Applications

Kittel

Kuehne

Laporte

2021

Adv Healthcare Materials

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Microgels are crosslinked, water‐swollen networks with a 10 nm to 100 µm diameter and can be modified chemically or biologically to render them biocompatible for advanced clinical applications. Depending on their intended use, microgels require different mechanical and structural properties, which can be engineered on demand by altering the biochemical composition, crosslink density of the polymer network, and the fabrication method. Here, the fundamental aspects of microgel research and development, as well as their specific applications for theranostics and therapy in the clinic, are discussed. A detailed overview of microgel fabrication techniques with regards to their intended clinical application is presented, while focusing on how microgels can be employed as local drug delivery materials, scavengers, and contrast agents. Moreover, microgels can act as scaffolds for tissue engineering and regeneration application. Finally, an overview of microgels is given, which already made it into pre‐clinical and clinical trials, while future challenges and chances are discussed. This review presents an instructive guideline for chemists, material scientists, and researchers in the biomedical field to introduce them to the fundamental physicochemical properties of microgels and guide them from fabrication methods via characterization techniques and functionalization of microgels toward specific applications in the clinic.

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Acitretin and aloe-emodin loaded chitin nanogel for the treatment of psoriasis

Cited by 92 publications

References 48 publications

Enhanced Lymphatic Uptake of Leflunomide Loaded Nanolipid Carrier via Chylomicron Formation for the Treatment of Rheumatoid Arthritis

Enhanced Lymphatic Uptake of Leflunomide Loaded Nanolipid Carrier via Chylomicron Formation for the Treatment of Rheumatoid Arthritis

Pivotal role of Acitretin nanovesicular gel for effective treatment of psoriasis: ex vivo–in vivo evaluation study

Translating Therapeutic Microgels into Clinical Applications

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Acitretin and aloe-emodin loaded chitin nanogel for the treatment of psoriasis

Cited by 92 publications

References 48 publications

Enhanced Lymphatic Uptake of Leflunomide Loaded Nanolipid Carrier via Chylomicron Formation for the Treatment of Rheumatoid Arthritis

Enhanced Lymphatic Uptake of Leflunomide Loaded Nanolipid Carrier via Chylomicron Formation for the Treatment of Rheumatoid Arthritis

Pivotal role of Acitretin nanovesicular gel for effective treatment of psoriasis: ex vivo&ndash;in vivo evaluation study

Translating Therapeutic Microgels into Clinical Applications

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Pivotal role of Acitretin nanovesicular gel for effective treatment of psoriasis: ex vivo–in vivo evaluation study