POEMS-Syndrom als seltene Ursache eines bilateralen Papillenödems

Birkenbach, A.; Kühlhorn, F.; Grube, Michael; Helbig, Horst; Gamulescu, Maria-Andreea

doi:10.1007/s00347-016-0287-8

Cited by 2 publications

(2 citation statements)

References 10 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additional case reports have been published to substantiate the relationship between papilledema as an initial presenting symptom and POEMS Syndrome for patients between 16 and 62 years. [134][135][136][137][138][139][140] The same studies have also outlined the presence of cystic macular edema (CME). [138][139][140][141] The etiology of ODE is thought to be elevated intracranial pressure and CSF protein, increased vascular permeability due to cytokines, inflammation (vasculitis), and infiltration.…”

Section: Systemic Amyloidosismentioning

confidence: 99%

Ocular complications of plasma cell dyscrasias

Singh

Singhal

Sinha

et al. 2023

European Journal of Ophthalmology

View full text Add to dashboard Cite

Plasma cell dyscrasias are a wide range of severe monoclonal gammopathies caused by pre-malignant or malignant plasma cells that over-secrete an abnormal monoclonal antibody. These disorders are associated with various systemic findings, including ophthalmological disorders. A search of PubMed, EMBASE, Scopus and Cochrane databases was performed in March 2021 to examine evidence pertaining to ocular complications in patients diagnosed with plasma cell dyscrasias. This review outlines the ocular complications associated with smoldering multiple myeloma and monoclonal gammopathy of undetermined significance, plasmacytomas, multiple myeloma, Waldenström's macroglobulinemia, systemic amyloidosis, Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes (POEMS) syndrome, and cryoglobulinemia. Although, the pathological mechanisms are not completely elucidated yet, wide-ranging ocular presentations have been identified over the years, evolving both the anterior and posterior segments of the eye. Moreover, the presenting symptoms also help in early diagnosis in asymptomatic patients. Therefore, it is imperative for the treating ophthalmologist and oncologist to maintain a high clinical suspicion for identifying the ophthalmological signs and diagnosing the underlying disease, preventing its progression through efficacious treatment strategies.

show abstract

Section: Systemic Amyloidosismentioning

confidence: 99%

Ocular complications of plasma cell dyscrasias

Singh

Singhal

Sinha

et al. 2023

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Its definitive diagnosis requires the presence of polyneuropathy and proof of clonal plasma cell proliferation that produces a monoclonal paraprotein, usually of the lambda type. POEMS syndrome is a rare entity, with an estimated prevalence of 0.3 cases per 100,000 inhabitants per year; the acronym, created by Barwick in 1980, refers to several of the syndrome´s distinctive features (polyneuropathy, organomegaly, endocrinopathy, measurable monoclonal component and cutaneous alterations); additionally, patients exhibit other manifestations such as: Papilledema (usually bilateral) [1]; extravascular volume overload revealed by edemas, pleural and pericardial effusion and ascites; sclerotic bone lesions and hematological alterations such as thrombocytosis or erythrocytosis [2].…”

Section: Introductionmentioning

confidence: 99%

POEMS Syndrome: A Multidisciplinary Diagnostic Challenge

Enciso¹,

Aponte²,

Rodríguez³

et al. 2017

J Clin Case Rep

View full text Add to dashboard Cite

POEMS syndrome is a paraneoplastic phenomenon associated with polyneuropathy and paraproteinemia that arises out of the clonal expansion of plasma tumor cells. Its other distinguishing features include sclerotic bone lesions, increased vascular endothelial growth factor levels, Castleman disease alterations in lymph node biopsy and association with organomegaly, endocrinopathy, cutaneous lesions, papilledema, extravascular volume overload and thrombocytosis. Although established diagnostic criteria exist, the fact that the disease is rare and shares similar clinical manifestations with non-neoplastic conditions means that in most cases patients are diagnosed at latestage, when multiple complications have appeared and treatments for other conditions have already been given. Therefore, a high degree of suspicion combined with a multidisciplinary approach are requisites for attaining precise diagnosis and providing timely treatment. Due to the wide differential diagnosis that the syndrome´s clinical features encompass as well as its subsequent favourable responses to bone marrow transplant and diverse chemotherapy treatments, clinicians from diverse fields should include the POEMS syndrome within polyneuropathy differential diagnoses that require specific diagnostic tests. Herein, we present our case study in which we emphasize diagnosis and treatment of patients treated at our institution.

show abstract

POEMS-Syndrom als seltene Ursache eines bilateralen Papillenödems

Cited by 2 publications

References 10 publications

Ocular complications of plasma cell dyscrasias

Ocular complications of plasma cell dyscrasias

POEMS Syndrome: A Multidisciplinary Diagnostic Challenge

Contact Info

Product

Resources

About