Decreased expression of Beclin-1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma

Hu, Zedong; Zhong, Zhaoming; Huang, Shao Mei; Wen, Haojie; Xue, Chen; Chu, Hongying; Li, Qiuli; Sun, Chuanzheng

doi:10.3892/mmr.2016.5437

Cited by 23 publications

(19 citation statements)

References 36 publications

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“…Meanwhile, our previous studies showed that the expression level of Bcl-xl was reduced in DHA-treated Cal-27 cells [ 8 ]. Consistently, one clinical study showed that Beclin-1 acted as a tumor suppressor in the development or progression of TSCC [ 37 ].…”

Section: Discussionmentioning

confidence: 64%

Dihydroartemisinin induces autophagy-dependent death in human tongue squamous cell carcinoma cells through DNA double-strand break-mediated oxidative stress

Shi

Wang

et al. 2017

Oncotarget

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Dihydroartemisinin is an effective antimalarial agent with multiple biological activities. In the present investigation, we elucidated its therapeutic potential and working mechanism on human tongue squamous cell carcinoma (TSCC). It was demonstrated that dihydroartemisinin could significantly inhibit cell growth in a dose- and time-dependent manner by the Cell Counting Kit-8 and colony formation assay in vitro. Meanwhile, autophagy was promoted in the Cal-27 cells treated by dihydroartemisinin, evidenced by increased LC3B-II level, increased autophagosome formation, and increased Beclin-1 level compared to dihydroartemisinin-untreated cells. Importantly, dihydroartemisinin caused DNA double-strand break with simultaneously increased γH2AX foci and oxidative stress; this inhibited the nuclear localization of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), finally leading to autophagic cell death. Furthermore, the antitumor effect of dihydroartemisinin-monotherapy was confirmed with a mouse xenograft model, and no kidney injury associated with toxic effect was observed after intraperitoneal injection with dihydroartemisinin for 3 weeks in vivo. In the present study, it was revealed that dihydroartemisinin-induced DNA double-strand break promoted oxidative stress, which decreased p-STAT3 (Tyr705) nuclear localization, and successively increased autophagic cell death in the Cal-27 cells. Thus, dihydroartemisinin alone may represent an effective and safe therapeutic agent for human TSCC.

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Section: Discussionmentioning

confidence: 64%

Dihydroartemisinin induces autophagy-dependent death in human tongue squamous cell carcinoma cells through DNA double-strand break-mediated oxidative stress

Shi

Wang

et al. 2017

Oncotarget

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“… 34 The prognostic role of Beclin-1 was investigated in various types of cancers, but the conclusions were inconsistent. It was shown by some studies that high level of Beclin-1 predicted a better outcome in colorectal carcinoma, 35 oral carcinoma, and multiple myeloma, 36 , 37 while other researchers showed that high level of Beclin-1 was correlated with a worse outcome in certain cancers such as endometrial carcinoma and nasopharyngeal carcinoma. 38 , 39 Moreover, some researches showed that Beclin-1 was not associated with prognosis of cancers.…”

Section: Discussionmentioning

confidence: 99%

Prognostic and clinicopathological significance of Beclin-1 in non-small-cell lung cancer: a meta-analysis

Zheng¹,

Li²,

et al. 2018

OTT

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BackgroundAutophagy plays a key role in the development of non-small-cell lung cancer (NSCLC). Beclin-1 is essential for the initiation and regulation of autophagy. Accumulated studies have investigated the prognostic role of Beclin-1 in NSCLC, but conclusions remain controversial. Therefore, we conducted this meta-analysis to assess the potential significance of Beclin-1 in NSCLC.Materials and methodsPubMed and Embase databases were searched for eligible studies published before December 31, 2017. Odds ratio (OR) was pooled to evaluate the clinicopathological significance of Beclin-1 in NSCLC. Hazard ratio (HR) was adopted to assess the association of Beclin-1 with overall survival (OS).ResultsEight studies involving 1,159 patients were included in this meta-analysis. The pooled results showed that high Beclin-1 expression was significantly correlated with earlier tumor grade (OR=0.54, 95% CI: 0.36–0.81, P=0.003), less nodal involvement (OR=0.56, 95% CI: 0.37–0.86, P=0.007), earlier TNM stage (OR=0.62, 95% CI: 0.43–0.89, P=0.010), smaller tumor size (OR=0.54, 95% CI: 0.36–0.81, P=0.003), better differentiation (OR=0.48, 95% CI: 0.36–0.64, P<0.001), and less recurrence (OR=0.24, 95% CI: 0.14–0.41, P<0.001). Moreover, high level of Beclin-1 was significantly associated with better OS in NSCLC (HR=0.41, 95% CI: 0.26–0.64, P<0.001).ConclusionOur meta-analysis suggests that high Beclin-1 expression predicts a better clinicopathological status and a better prognosis in NSCLC. Beclin-1 might act as a promising prognostic biomarker for NSCLC.

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“… 77 In TSCC cells, Beclin 1 expression in 14 TSCC tissues and five TSCC cell lines detected by RT-PCR and Western blotting was significantly decreased. 78 Beclin 1 expression detected by IHC was also decreased in 133 TSCC specimens. The decreased expression of Beclin 1 was associated with poor differentiation, lymph node metastasis, advanced clinical TNM, and a poor five-year overall survival.…”

Section: Beclin 1 and Head And Neck Cancersmentioning

confidence: 95%

<p>Autophagy-Related Beclin 1 and Head and Neck Cancers</p>

Hu¹,

Zhong²,

Gong³

et al. 2020

OTT

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Beclin 1, a positive regulator of autophagy, behaves as a double-edged sword in tumorigenesis. Beclin 1 contributes to tumor suppression by removing defective or damaged organelles and other cellular components; however, its activity can also stimulate cancer initiation and progression. In head and neck cancer, Beclin 1 overexpression promotes autophagy, which limits DNA damage and chromosomal instability and increases necrosis and inflammation by impacting apoptotic and autophagic pathways. This paper reviews the relationship between Beclin 1, carcinogenesis and head and neck cancer prognosis.

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Decreased expression of Beclin-1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma

Cited by 23 publications

References 36 publications

Dihydroartemisinin induces autophagy-dependent death in human tongue squamous cell carcinoma cells through DNA double-strand break-mediated oxidative stress

Dihydroartemisinin induces autophagy-dependent death in human tongue squamous cell carcinoma cells through DNA double-strand break-mediated oxidative stress

Prognostic and clinicopathological significance of Beclin-1 in non-small-cell lung cancer: a meta-analysis

<p>Autophagy-Related Beclin 1 and Head and Neck Cancers</p>

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