Identifying the brain regions associated with acute spasticity in patients diagnosed with an ischemic stroke

Barlow, Susan J

doi:10.1080/08990220.2016.1197114

Cited by 15 publications

(24 citation statements)

References 33 publications

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“…[ 31 ] The result of this study is consistent with that of past studies reporting that an association of spasticity with the gray matter includes the corticospinal tract pathway. [ 32 ]…”

Section: Discussionmentioning

confidence: 99%

Brain mapping for long-term recovery of gait after supratentorial stroke

Kim

Kyeong

Hee³

et al. 2018

Medicine

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The recovery of independent gait after stroke is a main goal of patients and understanding the relationship between brain lesions and the recovery of gait can help physicians set viable rehabilitation plans. Our study investigated the association between variables of gait parameters and brain lesions.Fifty poststroke patients with a mean age of 67.5 ± 1.3 years and an average duration after onset of 62.2 ± 7.9 months were included. Three-dimensional gait analysis and magnetic resonance imaging were conducted for all patients. Twelve quantified gait parameters of temporal-spatial, kinematic, and kinetic data were used. To correlate gait parameters with specific brain lesions, we used a voxel-based lesion symptom mapping analysis. Statistical significance was set to an uncorrected P value <.005 and cluster size >10 voxels.Based on the location of a brain lesion, the following results were obtained: The posterior limb of the internal capsule was significantly associated with gait speed and increased knee extension in the stance phase. The hippocampus and frontal lobe were significantly associated with cadence. The proximal corona radiata was significantly associated with stride length and affected the hip maximal extension angle in the stance phase. The paracentral lobule was significantly associated with the affected knee maximal flexion angle in the swing phase and with the affected ankle maximal dorsiflexion angle in the stance phase. The frontal lobe, thalamus, and the lentiform nucleus were associated with kinetic gait parameters.Cortical, proximal white matter, and learning-related and motor-related areas are mainly associated with one's walking ability after stroke.

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“…[ 31 ] The result of this study is consistent with that of past studies reporting that an association of spasticity with the gray matter includes the corticospinal tract pathway. [ 32 ]…”

Section: Discussionmentioning

confidence: 99%

Brain mapping for long-term recovery of gait after supratentorial stroke

Kim

Kyeong

Hee³

et al. 2018

Medicine

View full text Add to dashboard Cite

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“…Although the reported prevalence of spasticity following stroke is highly variable, ranging from 4 to 42.6%[2–5], few studies have investigated the effects of brain lesions on spasticity in patients with stroke[6, 7]. Nonetheless, several studies have demonstrated how brain lesions can contribute to the development of spasticity in stroke patients.…”

Section: Introductionmentioning

confidence: 99%

Which brain lesions produce spasticity? An observational study on 45 stroke patients

et al. 2019

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Spasticity is an important barrier that can hinder the restoration of function in stroke patients. Although several studies have attempted to elucidate the relationship between brain lesions and spasticity, the effects of specific brain lesions on the development of spasticity remain unclear. Thus, the present study investigated the effects of stroke lesions on spasticity in stroke patients. The present retrospective longitudinal observational study assessed 45 stroke patients using the modified Ashworth Scale to measure muscle spasticity. Each patient was assessed four times: initially (within 2 weeks of stroke) and at 1, 3, and 6 months after the onset of stroke. Brain lesions were analyzed using voxel-based lesion symptom mapping (VLSM) with magnetic resonance imaging images. Spasticity developed to a certain degree within 3 months in most stroke patients with spasticity. The VLSM method with non-parametric mapping revealed that lesions in the superior corona radiata, posterior limb of the internal capsule, posterior corona radiata, thalamus, putamen, premotor cortex, and insula were associated with the development of upper-limb spasticity. Additionally, lesions of the superior corona radiata, posterior limb of the internal capsule, caudate nucleus, posterior corona radiata, thalamus, putamen, and external capsule were associated with the development of lower-limb spasticity. The present study identified several brain lesions that contributed to post-stroke spasticity. Specifically, the involvement of white matter tracts and the striatum influenced the development of spasticity in the upper and lower limbs of stroke patients. These results may be useful for planning rehabilitation strategies and for understanding the pathophysiology of spasticity in stroke patients.

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“…The internal capsule is supplied by the middle cerebral artery. Damage in this region can result in motor impairment, particularly in the upper limbs 42,43 . The negative correlation observed in the two evaluations using the Motor Assessment Scale, Box and Block Test, and Chedoke-McMaster (arm) suggest that this structure can be used as a marker for the indication of VRT combined with conventional rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

Effects of virtual reality therapy on upper limb function after stroke and the role of neuroimaging as a predictor of a better response

Gonçalves

Piva

Marques

et al. 2018

Arq. Neuro-Psiquiatr.

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Background: Virtual reality therapy (VRT) is an interactive intervention that induces neuroplasticity. The aim was to evaluate the effects of VRT associated with conventional rehabilitation for an upper limb after stroke, and the neuroimaging predictors of a better response to VRT. Methods: Patients with stroke were selected, and clinical neurological, upper limb function, and quality of life were evaluated. Statistical analysis was performed using a linear model comparing pre- and post-VRT. Lesions were segmented in the post-stroke computed tomography. A voxel-based lesion-symptom mapping approach was used to investigate the relationship between the lesion and upper limb function. Results: Eighteen patients were studied (55.5 ± 13.9 years of age). Quality of life, functional independence, and dexterity of the upper limb showed improvement after VRT (p < 0.001). Neuroimaging analysis showed negative correlations between the internal capsule lesion and functional recovery. Conclusion: VRT showed benefits for patients with stroke, but when there was an internal capsule lesion, a worse response was observed.

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Identifying the brain regions associated with acute spasticity in patients diagnosed with an ischemic stroke

Cited by 15 publications

References 33 publications

Brain mapping for long-term recovery of gait after supratentorial stroke

Brain mapping for long-term recovery of gait after supratentorial stroke

Which brain lesions produce spasticity? An observational study on 45 stroke patients

Effects of virtual reality therapy on upper limb function after stroke and the role of neuroimaging as a predictor of a better response

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