SNPs in
            <i>NRXN1</i>
            and
            <i>CHRNA5</i>
            are Associated to Smoking and Regulation of Gabaergic and Glutamatergic Pathways

Pérez-Rubio, Gloría; Pérez-Rodríguez, Martha; Fernández-López, Juan Carlos; Ramírez‐Venegas, Alejandra; Garcı́a-Colunga, Jesús; Ávila‐Moreno, Federico; Camarena, Ángel; Sansores, Raúl H; Falfán-Valencia, Ramcés

doi:10.2217/pgs-2016-0020

Cited by 16 publications

(15 citation statements)

References 44 publications

(45 reference statements)

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“…Smokers recruited from the Smoking Cessation Support Clinic of the Department of Investigation in Tobacco Consumption and COPD at the Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER) in Mexico City, with the following criteria: individuals who started smoking in adolescence (<18 years) were defined as early smokers (ES) or those who started smoking in adulthood (≥18 years) defined as late smokers (LS); these subjects have been recruited previously in our research group [2] , [3] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Data on genotype frequency for SNPs associated to age of smoking onset and successful smoking cessation treatment

et al. 2019

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This article contains data on the allele and genotype frequency for single nucleotide polymorphisms (SNPs) in candidate genes CHRNA5 (rs16969968, rs17408276, rs680244) CHRNA3 (rs6495307, rs12914385) NRXN1 (rs10865246, rs1882296, rs985919) and HTR2A (rs6311, rs6313) previously evaluated as genetic risk variants for cigarette smoking at an early age and relapse to smoking cessation treatment Pérez-Rubio et al., 2018. These SNPs were selected due to previous associations in other populations, including Mexican Mestizos. Smokers were classified according to the age at onset, cigarettes per day, nicotine dependence, COPD status and therapy received.

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Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Data on genotype frequency for SNPs associated to age of smoking onset and successful smoking cessation treatment

et al. 2019

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“…Smokers recruited from the Smoking Cessation Support Clinic of the Department of Investigation in Tobacco Consumption and COPD at the Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER) in Mexico City, with the following criteria: had 10≥years smoking were classified according their smoking pattern in cigarette smoking per day (cpd) into light smokers (LS≤10 cpd) and heavy smokers (HS≥20 cpd), these subjects has been recruited previously in our research group [2] , [3] . A reference group of never-smokers healthy volunteers was selected with the same demographic characteristics.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Data on polymorphisms in CYP2A6 associated to risk and predispose to smoking related variables

et al. 2017

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This article contains data on the single nucleotide polymorphisms (SNPs) rs1137115, rs1801272 and rs28399433 rs4105144 in CYP2A6 associated to smoking related variables in Mexican Mestizo smokers (Pérez-Rubio et al., 2017) [1]. These SNPs were selected due to previous associations with other populations. Mexican Mestizo smokers were classified according their smoking pattern. A genetic association test was performed.

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“…Subsequently, rs1882296 in NRXN1 was associated with smoking risk in a Mexican population when comparing smokers to non-smokers. Using an in silico analysis, the presence of the risk allele (C) was observed to generate a miRNA capable of silencing genes that encode different receptors of the GA-BAergic and glutamatergic pathways compared to the presence of the common allele (T) 29 .…”

Section: Polymorphisms In Genes Related To Nicotine Addiction Identifmentioning

confidence: 99%

“…In a Russian population that included patients with COPD and clinically healthy individuals (26% non-smokers), it was found that the haplotype formed by alleles AAG in CHRNA3/A5 (rs16969968-rs1051730-r6495309) was present at a higher frequency in patients with COPD than in the control group 182 . In Mestizo Mexican populations, we have identified, using multi-stage association studies, polymorphisms in CHRNA5 (rs16969968 and rs17408276) that are associated with cigarette smoking 29 . A later analysis, including smokers with and without COPD, showed that patients with COPD and of Caucasian descent had a haplotype formed by 12 SNPs in CHRNA5/A3 (AGGAAGAGGGCA) that includes rs16969968 and rs17408276.…”

Section: Genetic Polymorphisms Related To Nicotine Addiction and Copdmentioning

confidence: 99%

Role of Genetic Susceptibility in Nicotine Addiction and Chronic Obstructive Pulmonary Disease

Pérez-Rubio

Córdoba-Lanús

Cupertino

et al. 2019

RIC

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Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality in developed countries. Although cigarette smoking is the major risk factor, only 10-20% of smokers develop COPD. The extent of cigarette smoking (pack-years and smoking duration) accounts for only 15% of the variation in lung function, indicating that differences in susceptibility to COPD must exist. We provide an overview of the complexity of nicotine addiction and COPD, with special attention to the involvement of genetic factors. The following aspects are discussed in the present article: (1) epidemiology in Mexico and (2) a review of the published literature on genetic association studies using the National Center for Biotechnology Information database of the United States as a search tool. COPD is unique among complex genetic diseases where an environmental risk factor is known and the level of exposure can be documented with some precision. The high morbidity and mortality associated with COPD and its chronic and progressive nature has prompted the use of molecular genetic studies to identify susceptibility factors for the disease. Biomedical research has a remarkable set of tools to aid in the discovery of genes and polymorphisms. We present a review of the most relevant genetic associations in nicotine addiction and COPD.

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SNPs in NRXN1 and CHRNA5 are Associated to Smoking and Regulation of Gabaergic and Glutamatergic Pathways

Abstract: In a Mexican Mestizo population, greater consumption of cigarettes was influenced by polymorphisms in the NRXN1 and CHRNA5 genes. We proposed new hypotheses regarding the putative roles of miRNAs that influence the GABAergic and glutamatergic pathways in smoking addiction.

Cited by 16 publications

References 44 publications

Data on genotype frequency for SNPs associated to age of smoking onset and successful smoking cessation treatment

Data on genotype frequency for SNPs associated to age of smoking onset and successful smoking cessation treatment

Data on polymorphisms in CYP2A6 associated to risk and predispose to smoking related variables

Role of Genetic Susceptibility in Nicotine Addiction and Chronic Obstructive Pulmonary Disease

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