d-Allose Attenuates Overexpression of Inflammatory Cytokines after Cerebral Ischemia/Reperfusion Injury in Gerbil

Shinohara, Naohide; Nakamura, Takehiro; Abe, Yuko; Hifumi, Toru; Kawakita, Kenya; Shinomiya, Aya; Tamiya, Takashi; Tokuda, Masaaki; Keep, Richard F.; Yamamoto, Tohru; Kuroda, Yasuhiro

doi:10.1016/j.jstrokecerebrovasdis.2016.01.030

Cited by 26 publications

(15 citation statements)

References 18 publications

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“…Previous studies have shown that following transient focal cerebral ischemia oxidative stress and overexpression of pro-inflammatory cytokines cause neurologic deficits, brain edema and neuronal death ( Liu et al, 2015a ; Yao et al, 2015 ; Shinohara et al, 2016 ). To evaluate neuroprotective effect of berberine, we first examined neurobehavioral function through behavioral assessment.…”

Section: Resultsmentioning

confidence: 99%

Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines

Maleki

Aboutaleb

Souri

2018

Journal of Chemical Neuroanatomy

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Section: Resultsmentioning

confidence: 99%

Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines

Maleki

Aboutaleb

Souri

2018

Journal of Chemical Neuroanatomy

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“…Among others, D-Allose is the most active compound in MECN, reported to inhibit mitochondrial reactive oxygen species in Neuro2A cells [ 32 ] as well as protect the brain from transient ischemic neural death [ 33 ]. During cerebral ischemia, this compound also inhibited the production of inflammatory cytokines and translocation of NF-κB components to protect blood-brain barrier [ 34 , 35 ]. Phytol was found to produce significant anxiolytic activity in mice which is mediated through its interaction with GABAergic system [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system

Moniruzzaman

Mannan

Khan

et al. 2018

BMC Complement Altern Med

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BackgroundCrataeva nurvala Buch-Hum is an indigenous herb, extensively used in traditional medicines of the South Asian countries to treat inflammation, rheumatic fever, gastric irritation, and constipation. Despite this wide range of uses, very little information is known regarding its effects on the central nervous system (CNS). Therefore, this study evaluated the neuropharmacological properties of methanolic extract of Crataeva nurvala leaves (MECN) using a number of behavioral models in animals. This study also identified potentially active phytochemicals in MECN.MethodsFollowing MECN administration (at 50, 100 and 200 mg/kg; b.w.) the animals (male Swiss albino mice) were employed in hole-cross test (HCT), open field test (OFT), and rota-rod test (RRT) to evaluate sedative properties, where anxiolytic activities were investigated using elevated plus maze (EPM), light dark box (LDB), and marble burying test (MBT). The involvement of GABAergic system was evaluated using thiopental sodium (TS)-induced sleeping time determination test. Moreover, colorimetric phytochemical tests as well as GC/MS-MS were also conducted to define the phytochemical constituents of MECN.ResultsMECN possesses sedative properties indicated through the dose-dependent inhibition of locomotor activities of the animals in HCT and OFT and motor coordination in RRT. MECN also exhibited prominent anxiolytic properties through decreased burying behavior in MBT, increased time spent and transitions in open arm of EPM, and increased time spent in light compartment of LDB. In addition, the treatments potentiated TS-mediated hypnosis indicating a possible participation of GABAergic system in the observed sedative and anxiolytic activities. Phytochemical screening of MECN revealed 48 different compounds in it. We reviewed and conceive that the sedative and anxiolytic effects could be due to the presence of neuroactive compounds such as phytol, D-allose, and α-Tocopherol in MECN.ConclusionThe present study showed that MECN possesses sedative and anxiolytic potential which could be beneficial in treatment of anxiety and insomnia associated with different psychological disorders.

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“…Bars indicated means ±SD. *** P < 0.001, ** P < 0.01 vs. Control; ### P < 0.001, ## P < 0.01 vs. IR;^^^P < 0.001,^^P < 0.01 vs. D-allose (Shinohara et al 2016). Moreover, Huang, T. et al noticed that the blood brain barrier could be protected by D-allose via mediating anti-inflammatory pathway when I/R injury occurred in mice (Huang et al 1642).…”

Section: Discussionmentioning

confidence: 98%

D-allose alleviates ischemia/reperfusion (I/R) injury in skin flap via MKP-1

Hou

Zhang

2020

Mol Med

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Background: D-allose was promising in the protection of ischemia/reperfusion (I/R) injury. We intended to investigate the function of D-allose in skin flap of rat followed by the injury of I/R and whether ERK signal pathway was involved in. Methods: The back flap of Wistar rats was picked up with a vascular bundle of the lateral chest wall. I/R model was made by the venous clamp for 6 h. Rats received D-allose and PD-98059, the inhibitor of ERK1/2, 30 min before modeling. Morphology of tissue was observed by HE staining. Nitric oxide (NO), myeloperoxidase (MPO), malondialdehyde (MDA) and superoxide dismutase (SOD) levels in skin flap were determined by ELISA kits. mRNA and protein levels were determined by qPCR and Western blot respectively. Results: D-allose alleviated the condition of pathological changes and raised the survival rate of skin flap injured by I/R. Moreover, D-allose suppressed NO, MPO and MDA while elevated SOD levels during I/R status. Furthermore, Dallose decreased MCP-1, TNF-α, IL-1β and IL-6 levels in skin flap injured by I/R. In addition, D-allose inhibited MKP-1 expression and activated ERK1/2 pathway in skin flap injured by I/R. PD-98059 partially counteracted D-allose effects on I/R injury. Conclusions: D-allose exerted its protective function via inhibiting MKP-1expression and further activated ERK1/2 pathway to suppress the progress of oxidative stress, inflammation and necrosis, contributing to the survival of skin flap injured by I/R. Thus, D-allose was promising in the transplantation of skin flap.

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d-Allose Attenuates Overexpression of Inflammatory Cytokines after Cerebral Ischemia/Reperfusion Injury in Gerbil

Cited by 26 publications

References 18 publications

Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines

Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines

The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system

D-allose alleviates ischemia/reperfusion (I/R) injury in skin flap via MKP-1

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