MIRAgel: the immunohistochemical expression of CD3, CD34, and CD68 in the surrounding capsule

Management of complex retinal detachment from intraocular invasion of MIRAgel-a case report

“…Roldan-Pallares et al previously examined the immunochemistry component of MIRAgel's capsule, which demonstrated CD3 + and CD20 − predominant expression. 5 Cases of retinal detachment after scleral perforation and MIRAgel intraocular exposure immediately after surgery have also shown higher CD3 and CD68 expression. 5 In our case, the intruding MIRAgel probably induced a similar inflammatory response within the eye, which explains the severe vitreous inflammation.…”

“… 5 Cases of retinal detachment after scleral perforation and MIRAgel intraocular exposure immediately after surgery have also shown higher CD3 and CD68 expression. 5 In our case, the intruding MIRAgel probably induced a similar inflammatory response within the eye, which explains the severe vitreous inflammation. The inflammation possibly caused a secondary tractional component, which eventually became one of the factors of retinal re-detachment.…”

Spätkomplikationen nach Verwendung einer Hydrogelplombe (MIRAgel®) bei Netzhautablösung

“…Diese häuften sich in der Folgezeit so auffallend, dass MIRA die Materialien 1996 in dieser Form vom Markt nahm. Zusätzlich neigten die Hydrogelplomben zu einer langfristigen Entzündungsreaktion, die u. a. auf die Expression von CD3, CD34 und CD68 zurückzuführen ist, die wiederum heftige Entzündungszustände auszulösen vermögen [7]. Inwieweit die eigentlichen Bestandteile des Materials oder aber die körpereigenen Immun-und Inflammationsmediatoren den Hauptanteil des entzündlichen Prozesses verursachen, ist noch nicht erschöpfend geklärt.…”

Long term observation of hydrogel buckle intrusion without vision loss

“…Progressive swelling of hydrogel buckle material (MIRAgel, MIRA Inc., Waltham, MA) used previously for retinal detachment has resulted in complications including progressive intrusion of the buckle material into the eye, a blind and painful eye, anterior extrusion and exposure of the buckle through the conjunctiva and tenons layer, recurrent detachment, vitreous hemorrhage, ptosis, strabismus, optic nerve compression, granuloma formation, and buckle expansion resulting in protrusion of the globe mimicking orbital pseudotumor or orbital cellulitis. 1 , 2 , 3 , 4 Hydrogel buckles were developed because of a potential advantage in a soft, conformable, and easily manipulated buckle material with an ability to absorb antibiotic to minimize secondary buckle infection. However, late progressive buckle swelling resulting in severe complications has led to the withdrawal of this buckle material off of the market.…”