Influence of triple disease modifying anti-rheumatic drug therapy on carotid artery inflammation in drug-naive patients with recent onset of rheumatoid arthritis

Haavisto, Matti; Saraste, Antti; Pirilä, Laura; Hannukainen, Jarna C.; Kalliokoski, Kari K.; Kirjavainen, Anna; Kemppainen, Jukka; Möttönen, Timo; Knuuti, Juhani; Yli‐Kerttula, Timo; Roivainen, Anne

doi:10.1093/rheumatology/kew240

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…[ 18 F] FDG micro-PET is a recently developed in vivo imaging tool for screening anti-inflammatory or anti-RA drugs. It allows the visualization of the metabolic activity in inflamed cells ( Haavisto et al, 2016 ). Therefore, we analyzed the accumulation of [ 18 F] FDG in the ankle and knee joints of CIA mice.…”

Section: Resultsmentioning

confidence: 99%

4-(Hydroxymethyl)catechol Extracted From Fungi in Marine Sponges Attenuates Rheumatoid Arthritis by Inhibiting PI3K/Akt/NF-κB Signaling

et al. 2018

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Rheumatoid arthritis (RA) is a progressive autoimmune disease specific to synovial joints; it causes joint damage and other systemic abnormalities, thereby leading to physical disability and early mortality. Marine sponge-derived fungi, Pestalotiopsis sp., secrete immunosuppressive compounds in the culture broth. In the present study, we isolated 4-(hydroxymethyl)catechol (4-HMC) from these fungal species, and evaluated its anti-RA effects using a murine collagen-induced arthritis model and tumor necrosis factor-α-stimulated human RA synovial fibroblasts. Oral 4-HMC administration decreased the clinical arthritis score, paw thickness, histologic and radiologic changes, and serum IgG1 and IgG2a levels. It prevented the proliferation of helper T (Th) 1/Th17 CD4+ lymphocytes isolated from inguinal lymph nodes, thereby reducing inflammatory cytokine production in CIA mice. It decreased the expression of inflammatory mediators, including cytokines and matrix metalloproteinases (MMPs), both in vitro and in vivo. We observed that 4-HMC suppresses Th immune responses and MMP expression to inhibit inflammatory cytokine production in human RA synovial fibroblasts by modulating the PI3K/Akt/NF-κB pathway. These results verify the anti-RA potential of 4-HMC.

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Section: Resultsmentioning

confidence: 99%

4-(Hydroxymethyl)catechol Extracted From Fungi in Marine Sponges Attenuates Rheumatoid Arthritis by Inhibiting PI3K/Akt/NF-κB Signaling

et al. 2018

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“…In our patients, we found no change in vascular in ammation at week 12 of treatment. Haavisto et al 17 showed a decrease in vascular in ammation after 4 weeks of triple csDMARDs therapy in treatment naïve patients with RA. Interestingly, this difference in results is in spite of similar SUV max values at baseline between both studies.…”

Section: Discussionmentioning

confidence: 98%

Endothelial inflammation in patients with Rheumatoid Arthritis treated with Tofacitinib

Vega,

Riopedre,

Peón

et al. 2023

Preprint

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Introduction: Cardiovascular involvement is frequent in patients with Rheumatoid Arthritis (RA). The use of tofacitinib has been linked with an increment in cardiovascular events in some populations of RA patients. 18F-Fluorodeoxyglucose Positron Emission Tomography (PET-FDG/TC) has emerged as a sensitive and specific test for the evaluation of vascular wall inflammation. The aim of this study is to evaluate the endothelial vascular inflammation using PET-FDG/TC in patients with active RA initiating tofacitinib, at baseline and after 12 weeks of treatment. Methods Observational, prospective, multicentric study. Consecutive patients with RA with moderate/high activity, bDMARD naïve, that were to start tofacitinib were included. Clinical data, disease activity and analytics were assessed. PET-FDG/TC was performed at baseline (week 0) and at week 12 of tofacitinib treatment. Endothelial inflammation was assessed using SUVmax and TBRmax. Carotid arteries doppler ultrasonography was performed at baseline and week 12 and intima-media thickness was measured. Results 30 patients were included. 70% female, median age 57.5 (IQR 42–65) years old, median RA duration 5 (IQR 2–12) years, Median DAS28ESR 5.24 (IQR 4.6–6.1) median CDAI 27.5 (IQR 20–34). At week 12 of tofacitinib treatment, patients showed a significant decrease in disease activity by DAS28ESR (5.21 vs 3.04, p < 0.0001) and CDAI (26.6 vs 8.80, p < 0.0001) but 18F-FDG uptake in the five evaluated areas showed no significant difference between baseline and week 12 with all explored vascular showing a SUVmax over the prestipulated threshold defining inflammation at baseline. Conclusion In our study, we found no change in vascular inflammation at week 12 of tofacitinib treatment, despite improvement in disease activity.

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“…[27]. These abnormalities were mostly drug-related and reversible after discontinuation of the treatment [8,10]. On renal biopsy, MPA typically presents as a pauci-immune (devoid of immune complexes), necrotizing and crescentic glomerulonephritis -which is why renal MPA often presents as a rapid progressive disease with advanced stage of renal failure [12].…”

Section: Discussionmentioning

confidence: 99%

Analysis of morphological and functional changes of kidney endothelium in systemic rheumatic diseases

Iegudina

2017

ScienceRise: Medical Science

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Influence of triple disease modifying anti-rheumatic drug therapy on carotid artery inflammation in drug-naive patients with recent onset of rheumatoid arthritis

Abstract: (18)F-FDG-PET/CT revealed that drug-naive patients with early RA show carotid artery inflammation that can be efficiently reduced by 1-month DMARD triple therapy.

Cited by 10 publications

References 34 publications

4-(Hydroxymethyl)catechol Extracted From Fungi in Marine Sponges Attenuates Rheumatoid Arthritis by Inhibiting PI3K/Akt/NF-κB Signaling

4-(Hydroxymethyl)catechol Extracted From Fungi in Marine Sponges Attenuates Rheumatoid Arthritis by Inhibiting PI3K/Akt/NF-κB Signaling

Endothelial inflammation in patients with Rheumatoid Arthritis treated with Tofacitinib

Analysis of morphological and functional changes of kidney endothelium in systemic rheumatic diseases

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