A Review of the Latest Advances in Encrypted Bioactive Peptides from Protein-Rich Waste

Lemes, Ailton César; Sala, Luisa; Ores, Joana da Costa; Braga, Anna Rafaela Cavalcante; Egea, Mariana Buranelo; Fernandes, Kátia Flávia

doi:10.3390/ijms17060950

Cited by 188 publications

(95 citation statements)

References 154 publications

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“…The ultrafiltration system using 1–10 kDa MWCO membranes is usually applied to separate bioactive peptides into fractions with different molecular weights [37,38]. This is because the size of ACE-inhibitory peptides is generally between 2 and 30 amino acids [39].…”

Section: Resultsmentioning

confidence: 99%

Antihypertensive properties of tilapia (Oreochromis spp.) frame and skin enzymatic protein hydrolysates

Lin

Alashi

Aluko

et al. 2017

Food & Nutrition Research

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Proteins from tilapia frame and skin can potentially be precursors of antihypertensive peptides according to the result of BIOPEP analyses. The aim was to generate peptides with inhibitory effects against angiotensin-converting enzyme (ACE) and renin from tilapia frame and skin protein isolates (FPI and SPI). The most active hydrolysate was then tested for blood pressure-lowering ability in spontaneously hypertensive rats (SHRs). Tilapia frame and skin protein hydrolysates (FPHs and SPHs) were respectively produced from FPI and SPI hydrolysis using pepsin, papain, or bromelain. The ACE-inhibitory activities of tilapia protein hydrolysates with varying degree of hydrolysis (DH) were evaluated. In order to enhance the activity, the hydrolysate was fractionated into four fractions (<1 kDa, 1–3 kDa, 3–5 kDa, and 5–10 kDa) and the one with the greatest ability to inhibit in vitro ACE and renin activities was subjected to oral administration (100 mg/kg body weight) to SHRs. Systolic and diastolic blood pressure (SBP and DBP), mean arterial pressure (MAP), and heart rates (HR) were subsequently measured within 24 h. The pepsin-hydrolyzed FPH (FPHPe) with the highest DH (23%) possessed the strongest ACE-inhibitory activity (IC50: 0.57 mg/mL). Its <1 kDa ultrafiltration fraction (FPHPe1) suppressed both ACE (IC50: 0.41 mg/mL) and renin activities more effectively than larger peptides. In addition, FPHPe1 significantly (p < 0.05) reduced SBP (maximum −33 mmHg), DBP (maximum −24 mmHg), MAP (maximum −28 mmHg), and HR (maximum −58 beats) in SHRs. FPHPe1 showed both in vitro and in vivo antihypertensive effects, which suggest tilapia processing coproducts may be valuable protein raw materials for producing antihypertensive peptides.

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Section: Resultsmentioning

confidence: 99%

Antihypertensive properties of tilapia (Oreochromis spp.) frame and skin enzymatic protein hydrolysates

Lin

Alashi

Aluko

et al. 2017

Food & Nutrition Research

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“…Citrus fruits are processed, not only to obtain juice, but also, in the canning industry to produce jam and segments of mandarin. Lemes et al (2016) reported bioactive peptides as the new generation of biologically active regulators that can prevent oxidation and microbial degradation in foods, and might be helpful in treatment of various diseases. These can be extracted from residual waste and incorporated into value added products.…”

Section: Food Waste As a Source Of Bioactive Compoundsmentioning

confidence: 99%

Food waste: a potential bioresource for extraction of nutraceuticals and bioactive compounds

Kumar

Yadav

Kumar

et al. 2017

Bioresour. Bioprocess.

337

148

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Food waste, a by-product of various industrial, agricultural, household and other food sector activities, is rising continuously due to increase in such activities. Various studies have indicated that different kind of food wastes obtained from fruits, vegetables, cereal and other food processing industries can be used as potential source of bioactive compounds and nutraceuticals which has significant application in treating various ailments. Different secondary metabolites, minerals and vitamins have been extracted from food waste, using various extraction approaches. In the next few years these approaches could provide an innovative approach to increase the production of specific compounds for use as nutraceuticals or as ingredients in the design of functional foods. In this review a comprehensive study of various techniques for extraction of bioactive components citing successful research work have been discussed. Further, their efficient utilization in development of nutraceutical products, health benefits, bioprocess development and value addition of food waste resources has also been discussed.

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“…As discussed, the main component of meat co-products, on a dry basis, is protein; thus, these 206 by-products are a potential source of bioactive peptides which can be extracted, purified and 207 commercialised as a very high-added value product (Lemes et al, 2016 preventing heart disease (Williams, 2007) hence exudate and cook-out may be good sources.…”

mentioning

confidence: 99%

Alternative uses for co-products: Harnessing the potential of valuable compounds from meat processing chains

et al. 2017

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A Review of the Latest Advances in Encrypted Bioactive Peptides from Protein-Rich Waste

Cited by 188 publications

References 154 publications

Antihypertensive properties of tilapia (Oreochromis spp.) frame and skin enzymatic protein hydrolysates

Antihypertensive properties of tilapia (Oreochromis spp.) frame and skin enzymatic protein hydrolysates

Food waste: a potential bioresource for extraction of nutraceuticals and bioactive compounds

Alternative uses for co-products: Harnessing the potential of valuable compounds from meat processing chains

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