Quantification of diffusion and anisotropy in intracranial epidermoids using diffusion tensor metrics and p: q tensor decomposition

Srinivasan, K.; Shah, Drishti; Kannath, Santhosh Kumar; Menon, Girish; Sandhyamani, S; Kesavadas, Chandrasekharan; Kapilamoorthy, T.R.

doi:10.1016/j.neurad.2016.02.003

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Srinivasan et al . have recently used it to distinguish intracranial epidermoids from normal white matter in the splenium of the corpus callosum [ 37 ]. In this study, we first examined concurrent changes in both magnitude and direction across the full panel of DTI measures, and interpreted them; we further corroborated this graphically by using PQ plots.…”

Section: Methodsmentioning

confidence: 99%

Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus

et al. 2017

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BackgroundThe pathogenesis of normal pressure hydrocephalus (NPH) remains unclear which limits both early diagnosis and prognostication. The responsiveness to intervention of differing, complex and concurrent injury patterns on imaging have not been well-characterized. We used diffusion tensor imaging (DTI) to explore the topography and reversibility of white matter injury in NPH pre- and early after shunting.MethodsTwenty-five participants (sixteen NPH patients and nine healthy controls) underwent DTI, pre-operatively and at two weeks post-intervention in patients. We interrogated 40 datasets to generate a full panel of DTI measures and corroborated findings with plots of isotropy (p) vs. anisotropy (q).ResultsConcurrent examination of DTI measures revealed distinct profiles for NPH patients vs. controls. PQ plots demonstrated that patterns of injury occupied discrete white matter districts. DTI profiles for different white matter tracts showed changes consistent with i) predominant transependymal diffusion with stretch/ compression, ii) oedema with or without stretch/ compression and iii) predominant stretch/ compression. Findings were specific to individual tracts and dependent upon their proximity to the ventricles. At two weeks post-intervention, there was a 6·7% drop in axial diffusivity (p = 0·022) in the posterior limb of the internal capsule, compatible with improvement in stretch/ compression, that preceded any discernible changes in clinical outcome. On PQ plots, the trajectories of the posterior limb of the internal capsule and inferior longitudinal fasciculus suggested attempted ‘round trips’. i.e. return to normality.ConclusionDTI profiling with p:q correlation may offer a non-invasive biomarker of the characteristics of potentially reversible white matter injury.

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Section: Methodsmentioning

confidence: 99%

Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus

et al. 2017

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Quantitative analysis in peritumoral volumes of brain metastases treated with stereotactic radiotherapy

Kim

Park

et al. 2018

Journal of Neuroradiology

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Anisotropy component of DTI reveals long-term neuroinflammation following repetitive mild traumatic brain injury in rats

Cheng,

Lu,

Hsieh

et al. 2024

Eur Radiol Exp

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Background This study aimed to investigate the long-term effects of repetitive mild traumatic brain injury (rmTBI) with varying inter-injury intervals by measuring diffusion tensor metrics, including mean diffusivity (MD), fractional anisotropy (FA), and diffusion magnitude (L) and pure anisotropy (q). Methods Eighteen rats were randomly divided into three groups: short-interval rmTBI (n = 6), long-interval rmTBI (n = 6), and sham controls (n = 6). MD, FA, L, and q values were analyzed from longitudinal diffusion tensor imaging at days 50 and 90 after rmTBI. Immunohistochemical staining against neurons, astrocytes, microglia, and myelin was performed. Analysis of variance, Pearson correlation coefficient, and simple linear regression model were used. Results At day 50 post-rmTBI, lower cortical FA and q values were shown in the short-interval group (p ≤ 0.038). In contrast, higher FA and q values were shown for the long-interval group (p ≤ 0.039) in the corpus callosum. In the ipsilesional external capsule and internal capsule, no significant changes were found in FA, while lower L and q values were shown in the short-interval group (p ≤ 0.028) at day 90. The q values in the external capsule and internal capsule were negatively correlated with the number of microglial cells and the total number of astroglial cells (p ≤ 0.035). Conclusion Tensor scalar measurements, such as L and q values, are sensitive to exacerbated chronic injury induced by rmTBI with shorter inter-injury intervals and reflect long-term astrogliosis induced by the cumulative injury. Relevance statement Tensor scalar measurements, including L and q values, are potential DTI metrics for detecting long-term and subtle injury following rmTBI; in particular, q values may be used for quantifying remote white matter (WM) changes following rmTBI. Key Points The alteration of L and q values was demonstrated after chronic repetitive mild traumatic brain injury. Changing q values were observed in the impact site and remote WM. The lower q values in the remote WM were associated with astrogliosis. Graphical Abstract

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Quantification of diffusion and anisotropy in intracranial epidermoids using diffusion tensor metrics and p: q tensor decomposition

Cited by 3 publications

References 18 publications

Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus

Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus

Quantitative analysis in peritumoral volumes of brain metastases treated with stereotactic radiotherapy

Anisotropy component of DTI reveals long-term neuroinflammation following repetitive mild traumatic brain injury in rats

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