Acute-phase proteins in prediction of preeclampsia in patients with abnormal midtrimester uterine Doppler velocimetry

Stubert, Johannes; Kleber, T; Bolz, Michael; Külz, T; Dieterich, M.; Richter, Dagmar; Reimer, Toralf

doi:10.1007/s00404-016-4138-2

Cited by 13 publications

(3 citation statements)

References 48 publications

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“…Previous studies revealed that progranulin concentrations in the plasma are significantly higher in patients with inflammation-related disease (such as inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus), as well as in infants with earlyonset sepsis compared with those without these conditions [57,58]. In the obstetric field, previous studies on maternal plasma and placental samples showed a significantly upregulated expression of progranulin in patients with preeclampsia or fetal growth restriction as compared with those without these complications [59,60]. These results contrast with the present findings on decreased plasma progranulin levels with respect to CNMM.…”

Section: Discussionmentioning

confidence: 99%

Plasma Kallistatin and Progranulin as Predictive Biomarkers of Intraamniotic Inflammation, Microbial Invasion of the Amniotic Cavity, and Composite Neonatal Morbidity/Mortality in Women With Preterm Premature Rupture of Membranes

Park,

Lee,

Cho

et al. 2024

American J Rep Immunol

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ProblemTo explore the clinical utility of nine inflammatory immune‐, adhesion‐, and extracellular matrix‐related mediators in the plasma for predicting intraamniotic inflammation and/or microbial invasion of the amniotic cavity (IAI/MIAC) and composite neonatal morbidity and/or mortality (CNMM) in women with preterm premature rupture of membranes (PPROM) when used alone or in combination with conventional blood‐, ultrasound‐, and clinical‐based factors.Methods of StudyThis retrospective cohort comprised 173 singleton pregnant women with PPROM (24 + 0 – 33 + 6 weeks), who underwent amniocentesis. Amniotic fluid was cultured for microorganisms and assayed for IL‐6 levels. Plasma levels of AFP, CXCL14, E‐selectin, Gal‐3BP, kallistatin, progranulin, P‐selectin, TGFBI, and VDBP were determined by ELISA. Ultrasonographic cervical length (CL) and neutrophil‐to‐lymphocyte ratio (NLR) were measured.ResultsMultivariate logistic regression analyses revealed significant associations between (i) decreased plasma kallistatin levels and IAI/MIAC and (ii) decreased plasma progranulin levels and increased CNMM risk after adjusting for baseline variables (e.g., gestational age at sampling [or delivery] and parity). Using stepwise regression analysis, noninvasive prediction models for IAI/MIAC and CNMM risks were developed, which included plasma progranulin levels, NLR, CL, and gestational age at sampling, and provided a good prediction of the corresponding endpoints (area under the curve: 0.79 and 0.87, respectively).ConclusionsKallistatin and progranulin are potentially valuable plasma biomarkers for predicting IAI/MIAC and CNMM in women with PPROM. Particularly, the combination of these plasma biomarkers with conventional blood‐, ultrasound‐, and clinical‐based factors can significantly support the diagnosis of IAI/MIAC and CNMM.

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Section: Discussionmentioning

confidence: 99%

Plasma Kallistatin and Progranulin as Predictive Biomarkers of Intraamniotic Inflammation, Microbial Invasion of the Amniotic Cavity, and Composite Neonatal Morbidity/Mortality in Women With Preterm Premature Rupture of Membranes

Park,

Lee,

Cho

et al. 2024

American J Rep Immunol

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“…Therefore, it is one of the focuses of preeclampsia research to study the molecular mechanism of trophoblast cell migration and limited invasion ability. A full understanding of the molecular changes in this process is expected to provide theoretical basis and experimental support for the prevention and treatment of preeclampsia (20). Cell scratch test is an effective method to detect cell movement.…”

Section: Comparison Of Clinical Data Between Preeclampsia Patients An...mentioning

confidence: 99%

Expression levels of serum mir-145-5p and Gas6 in women with early-onset preeclampsia and their clinical significance

Huang

Zhang

2022

Cell Mol Biol (Noisy-le-grand)

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Early preeclampsia is a pregnancy-specific clinical disease, its pathogenesis is not clear, and clinical treatment is limited. Therefore, it is particularly important to study the pathogenesis of early preeclampsia, so as to provide evidence for the diagnosis and effective treatment of early preeclampsia. This research was carried out to investigate the expression levels and clinical significance of mir-145-5p and stagflation specific gene 6 (Gas6) in serum of women with early preeclampsia. For this purpose, 142 patients with preeclampsia were divided into the early-onset group (n=78) and the late-onset group (n=64) according to the onset time. Meanwhile, 70 normal pregnant women were selected as the control group. The levels of serum Gas6, mir-145-5p and inflammatory factors were detected. Logistic regression analysis showed that the expression levels of serum gas-6 and serum mir-145-5p were valuable in the diagnosis of early preeclampsia. ROC curve was established to evaluate the diagnostic efficacy of serum Gas6 level in early-onset preeclampsia. Its sensitivity and specificity were 91.23% and 64.2%, respectively, and the cutting value was 255.71pg/mL. The serum Gas6 level was negatively correlated with systolic blood pressure (r=-0.349, P<0.05) and positively correlated with platelet count (r=0.391, P<0.05). Compared with the control group, serum levels of mir-145-5p and TNF-a in women with early-onset preeclampsia were negatively correlated (r=-0.460~0.622, P<0.05). Conclusion: the serum level of Gas6 was reduced in patients with early-onset preeclampsia, and TNF-a inhibited the invasion of SVneo cells by upregulating mir-145-5p.

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“…Multiple recent studies have demonstrated increased serum levels of IL-1β, 171,172 IL-6, 172–175 IL-8, 176 IL-10, 172,173 CRP, 172,175,177 TNF-α 172,173,175 and IFN-γ 174,178 in women with preeclampsia compared with women with normotensive pregnancies; however, these results remain inconclusive. 179 From all of the inflammatory biomarkers investigated, CRP, IL-6, IL-8, and TNF-α hold the most promise for early identification of women with preeclampsia, 180 yet there is not enough evidence supporting the prognostic ability of individual inflammatory markers in predicting the development of preeclampsia, 172,179–181 which may be due to discrepancies among gestational timepoints and population studied. The combination of several biomarkers may afford greater predictive ability for identifying preeclampsia onset or prognosis, but more research is needed.…”

Section: Preeclampsiamentioning

confidence: 99%

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

Mattina

Lieshout

Steiner

2019

Therapeutic Advances in Cardiovascular Disease

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Women are at increased risk for developing depression and cardiovascular disease (CVD) across the lifespan and their comorbidity is associated with adverse outcomes that contribute significantly to rates of morbidity and mortality in women worldwide. Immunesystem activity has been implicated in the etiology of both depression and CVD, but it is unclear how inflammation contributes to sex differences in this comorbidity. This narrative review provides an updated synthesis of research examining the association of inflammation with depression and CVD, and their comorbidity in women. Recent research provides evidence of pro-inflammatory states and sex differences associated with alterations in the hypothalamic-pituitary-adrenal axis, the renin-angiotensin-aldosterone system and the serotonin/kynurenine pathway, that likely contribute to the development of depression and CVD. Changes to inflammatory cytokines in relation to reproductive periods of hormonal fluctuation (i.e. the menstrual cycle, perinatal period and menopause) are highlighted and provide a greater understanding of the unique vulnerability women experience in developing both depressed mood and adverse cardiovascular events. Inflammatory biomarkers hold substantial promise when combined with a patient's reproductive and mental health history to aid in the prediction, identification and treatment of the women most at risk for CVD and depression. However, more research is needed to improve our understanding of the mechanisms underlying inflammation in relation to their comorbidity, and how these findings can be translated to improve women's health.

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Acute-phase proteins in prediction of preeclampsia in patients with abnormal midtrimester uterine Doppler velocimetry

Cited by 13 publications

References 48 publications

Plasma Kallistatin and Progranulin as Predictive Biomarkers of Intraamniotic Inflammation, Microbial Invasion of the Amniotic Cavity, and Composite Neonatal Morbidity/Mortality in Women With Preterm Premature Rupture of Membranes

Plasma Kallistatin and Progranulin as Predictive Biomarkers of Intraamniotic Inflammation, Microbial Invasion of the Amniotic Cavity, and Composite Neonatal Morbidity/Mortality in Women With Preterm Premature Rupture of Membranes

Expression levels of serum mir-145-5p and Gas6 in women with early-onset preeclampsia and their clinical significance

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

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