Normal values of urine total protein- and albumin-to-creatinine ratios in term newborns

Hamel, Chahrazed El; Chianea, Thierry; Thon, Séverine; Lepichoux, Anne; Yardin, Catherine; Guigonis, Vincent

doi:10.1007/s00467-016-3427-0

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…Proteinuria/Creatininuria ratio was defined as pathologic if it was greater than 50 mg/mmol between 6 months and 2 years of age and greater than 20 mg/mmol after 2 years old [17]. No validated references for proteinuria/creatininuria ratio are available before 6 months old but normal values are probably more important than 50 mg/mmol [18,19]. We therefore considered patients under 6 months old to have pathological proteinuria if they had a proteinuria/creatininuria ratio greater than 50 mg/mmol.…”

Section: Methodsmentioning

confidence: 99%

Proteinuria and albuminuria prevalence in allergic children

MOULU,

Ponthier,

Chianea

et al. 2024

Preprint

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BACKGROUND: Numerous studies have reported an atopic background in patients suffering from idiopathic nephrotic syndrome. Proteinuria has also been reported in allergic patients, but in a limited number of studies with, for most of them, a low level of evidence. If confirmed, the presence of proteinuria in allergic children could be a clue that could help to understand idiopathic nephrotic syndrome pathophysiology. We conducted a prospective study to compare the urine protein levels in allergic and non- allergic children. METHODS Urine samples were collected from 196 children with a suspicion of allergy. Total protein, albumin, and creatinine were measured in urine. Included patients were secondary dispatched in allergic and non-allergic groups. RESULTS In the allergic group (n=99), six children (6%) were proteinuric (proteinuria/creatinuria ratio ranging from 20 to 1449 mg/mmol versus eight (8%) (21 to 219 mg/mmol) among the non-allergic patients (n=97). There was no significant difference between allergic and non-allergic patients either for proteinuria/creatininuria ratio (mean 28.13 and 18.18 mg/mmol respectively) or albuminuria/creatininuria ratio (mean 9.84 and 3.04 mg/mmol respectively). CONCLUSION Allergic patients do not present proteinuria more frequently than non- allergic patients. These results do not support a pathophysiological link that could lead from allergy to idiopathic nephrotic syndrome through the presence of pathologic proteinuria in allergic patients.

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Section: Methodsmentioning

confidence: 99%

Proteinuria and albuminuria prevalence in allergic children

MOULU,

Ponthier,

Chianea

et al. 2024

Preprint

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“…To detect proteinuria, we measured albumin, α-1-microglobulin, transferrin, immunoglobulin G and total protein in spontaneous urine and normalized the measured values by urine creatinine level. We compared the measured urine excretion of the listed parameters with respective specific limits [24][25][26], except for transferrin, for which no neonatal reference values are available, to again investigate whether one group (IUGR or controls) exceeded the limits more frequently than the other. All collected blood and urine samples were processed immediately at the central laboratory facility of the University Hospital Bonn.…”

Section: Laboratory Testingmentioning

confidence: 99%

Blood pressure and kidney function in neonates and young infants with intrauterine growth restriction

et al. 2022

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Background Intrauterine growth restriction (IUGR) has been associated with changes in kidney anatomy, nephrogenesis and the vascular system, resulting in secondary arterial hypertension and kidney damage in adulthood. Here, we compare routine clinical and metabolic parameters between IUGR and non-IUGR study participants in the neonatal and early infant period. Methods A total of 39 IUGR and 60 non-IUGR neonates were included during an 18-month study period. We compared blood pressure, serum creatinine (SCr), urea nitrogen (BUN), urinary albumin, α-1-microglobulin, transferrin, immunoglobulin G and total protein excretion in spontaneous urine normalized by urine creatinine level during the hospital stay. Results There were no significant differences in mean values of blood pressure and urinary protein excretion between cases and controls. SCr and BUN levels were lower in the IUGR group compared to the non-IUGR group. Conclusions The lower levels of SCr and BUN may be attributed to lower liver and muscle mass in IUGR neonates and young infants. Biomarkers currently used in routine clinical care do not allow early postnatal prediction of higher blood pressure or worse kidney function due to IUGR, so further studies are needed. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information.

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“…Peu de données sont disponibles pour les valeurs de référence de la protéinurie chez le nouveau-né à terme, en particulier si on prend en compte les méthodes de dosage de référence actuelles (chromatographie liquide couplée à la spectrométrie de masse avec dilution isotopique (LC-IDMS) [2][3][4][5]. Une étude récente portant sur 277 nouveau-nés à terme sans aucune pathologie rénale a permis de définir des limites supérieures de protéinurie/créatinine urinaire et d'albuminurie/créatinine urinaire (tableau 1) [6]. Une seconde étude portant sur plus de 1 400 enfants âgés de 7 à 18 ans a mis en évidence des variations par classes d'âge et de sexe avec une valeur pouvant être considérée comme pathologique uniquement en cas de de protéinurie supérieure à 28 mg/mmol [7].…”

Section: Valeurs Normales De Protéinurie En Fonction De L'âge En Pédi...unclassified

Proteinuria in pediatrics: from screening to diagnosis and monitoring of kidney disease

Fila¹,

Hemery²,

Morin³

2019

Annales De Biologie Clinique

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Normal values of urine total protein- and albumin-to-creatinine ratios in term newborns

Cited by 8 publications

References 17 publications

Proteinuria and albuminuria prevalence in allergic children

Proteinuria and albuminuria prevalence in allergic children

Blood pressure and kidney function in neonates and young infants with intrauterine growth restriction

Proteinuria in pediatrics: from screening to diagnosis and monitoring of kidney disease

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