273 A phase I study of concomitant chemoradiotherapy with cisplatin (CDDP) and vinorelbine (NVB) for advanced malignancies of the chest

Masters, G.; Drinkard, L. C.; Haraf, D.; Krauss, Stephen; Olak, Jemi; Ferguson, Michelle; Watson, S.; Golomb, Harvey M.; Vokes, Everett E.

doi:10.1016/s0169-5002(97)89655-9

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Lung Cancer1

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1997

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“…Vinorelbine with cisplatin has been tested concurrently with radiation therapy with major sideeffects of esophagitis and myelosuppression (79), and as neoadjuvant chemotherapy to downstage patients with inoperable stage II-IIIB disease with an initial response rate of 42% (80). Larger trials are needed to better define the usefulness of this agent in earlier disease.…”

Section: Lung Cancermentioning

confidence: 99%

Vinorelbine (Navelbiner`): A Third-Generation Vinca Alkaloid

Budman

1997

Cancer Investigation

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The vinca alkaloids represent one of the oldest classes of antineoplastic agents used in humans with a wide spectrum of activity against both animal and human tumors. These agents are known to inhibit microtubule polymerization. Vinorelbine is a semisynthetic analog that reached clinical trial on the basis of less preclinical evidence of toxicity to neuronal tissue and greater cytotoxic activity in preclinical models than the older compounds of this class. In humans, the clearance of this agent shows a wide variation among subjects with the predominant toxicity being hematological. Significant antitumor activity has been observed in diseases that previously have been shown to respond to vinca alkaloids.

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Section: Lung Cancermentioning

confidence: 99%

Vinorelbine (Navelbiner`): A Third-Generation Vinca Alkaloid

Budman

1997

Cancer Investigation

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273 A phase I study of concomitant chemoradiotherapy with cisplatin (CDDP) and vinorelbine (NVB) for advanced malignancies of the chest

Cited by 1 publication

References 0 publications

Vinorelbine (Navelbiner`): A Third-Generation Vinca Alkaloid

Vinorelbine (Navelbiner`): A Third-Generation Vinca Alkaloid

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