Brachytherapy Using Elastin-Like Polypeptides with 131I Inhibit Tumor Growth in Rabbits with VX2 Liver Tumor

Liu, Xinpei; Shen, Yuntian; Zhang, Xuqian; Lin, Rui; Jia, Qiang; Chang, Yixiang; Liu, Wenge; Liu, Wentian

doi:10.1007/s10620-016-4212-4

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Liu X et al developed a 131 I –labeled ELPs for radiotherapy and explored their antitumor effect in rabbits with VX2 liver tumors ( Liu et al, 2016 ). ELPs delivering 131 I could improve liver function and inhibit tumor growth.…”

Section: Drug-loaded Elps For Cancer Therapymentioning

confidence: 99%

Engineered elastin-like polypeptides: An efficient platform for enhanced cancer treatment

Jiang

Guan

et al. 2023

Front. Pharmacol.

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Drug delivery systems (DDSs) have recently gained widespread attention for improving drug loading and delivery efficiency in treating many cancers. Elastin-like polypeptides (ELPs) are synthetic peptides derived from a precursor of elastin (tropoelastin), reserving similar structural and physicochemical properties. ELPs have gained a variety of applications in tissue engineering and cancer therapy due to their excellent biocompatibility, complete degradability, temperature-responsive property, controllable sequence and length, and precisely tuned structure and function. ELPs-based drug delivery systems can improve the pharmacokinetics and biodistribution of therapeutic reagents, leading to enhanced antitumor efficacy. In this review, we summarize the recent application of ELPs in cancer treatment, focusing on the delivery of functional peptides, therapeutic proteins, small molecule drugs, and photosensitizers.

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Section: Drug-loaded Elps For Cancer Therapymentioning

confidence: 99%

Engineered elastin-like polypeptides: An efficient platform for enhanced cancer treatment

Jiang

Guan

et al. 2023

Front. Pharmacol.

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“…A recent ultrasound-based therapy study has linked the importance of the ECM for therapy options by using microbubbles to influence the interstitial fluid pressure in this model 14 . Furthermore, it could already be shown that brachytherapy using the genetically engineered peptide polymer elastin-like polypeptide labelled with I(131) in the VX2 liver tumors has a strong labelling efficiency and thus a high antitumor effect 15 . Non-invasive magnetic resonance imaging (MRI) biomarkers could enhance the current knowledge about ECM interactions following tumor progression and therapy.…”

mentioning

confidence: 99%

Assessment of the hepatic tumor extracellular matrix using elastin-specific molecular magnetic resonance imaging in an experimental rabbit cancer model

Keller

Borde

Brangsch

et al. 2020

Sci Rep

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To investigate the imaging performance of an elastin-specific molecular magnetic resonance imaging (MRI) probe with respect to the extracellular matrix (ECM) in an experimental hepatic cancer model. Twelve rabbits with hepatic VX2 tumors were examined using 3 T MRI 14, 21, and 28 days after tumor implantation for two subsequent days (gadobutrol, day 1; elastin-specific probe, day 2). The relative enhancement (RE) of segmented tumor regions (central and margin) and the peritumoral matrix was calculated using pre-contrast and delayed-phase T1w sequences. MRI measurements were correlated to histopathology and element-specific and spatially resolved mass spectrometry (MS). Mixed-model analysis was performed to assess the performance of the elastin-specific probe. In comparison to gadobutrol, the elastin probe showed significantly stronger RE, which was pronounced in the tumor margin (day 14–28: P ≤ 0.007). In addition, the elastin probe was superior in discriminating between tumor regions (χ2(4) = 65.87; P < 0.001). MRI-based measurements of the elastin probe significantly correlated with the ex vivo elastinstain (R = .84; P <0 .001) and absolute gadolinium concentrations (ICP-MS: R = .73, P <0 .01). LA-ICP-MS imaging confirmed the colocalization of the elastin-specific probe with elastic fibers. Elastin-specific molecular MRI is superior to non-specific gadolinium-based contrast agents in imaging the ECM of hepatic tumors and the peritumoral tissue.

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Applications of 3D printing in tumor treatment

Liang

Chen

et al. 2024

Biomedical Technology

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Brachytherapy Using Elastin-Like Polypeptides with 131I Inhibit Tumor Growth in Rabbits with VX2 Liver Tumor

Abstract: Elastin-like polypeptide can be an ideal carrier of (131)I and have high labeling efficiency, radiochemical purity and stability. Brachytherapy using elastin-like polypeptide with (131)I for liver tumor is a useful therapy that possesses high antitumor efficacy advantages.

Cited by 4 publications

References 15 publications

Engineered elastin-like polypeptides: An efficient platform for enhanced cancer treatment

Engineered elastin-like polypeptides: An efficient platform for enhanced cancer treatment

Assessment of the hepatic tumor extracellular matrix using elastin-specific molecular magnetic resonance imaging in an experimental rabbit cancer model

Applications of 3D printing in tumor treatment

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