Pathological Gambling in Parkinson's disease patients: Dopaminergic medication or personality traits fault?

Brusa, Livia; Pavino, Valentina; Massimetti, Maria Carla; Ceravolo, Roberto; Stefani, S. De; Stanzione, Paolo

doi:10.1016/j.jns.2016.03.032

Cited by 13 publications

(11 citation statements)

References 7 publications

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“…Regarding DAs themselves, recent studies of non-ergoline DAs in PD suggested higher rates of ICDs in patients treated with oral versus transdermal DAs,39 and oral short-acting versus oral long-acting/transdermal DAs,40 suggesting that DA administration route and formulation may play a role in ICD development. Furthermore, pre-PD history of an ICD has been reported as the main risk factor for ICD development during treatment with a DA,9 and specific personality traits were reported to play a role in the development of pathological gambling in patients with PD 26. Finally, because the role of DAs in ICD development in PD is increasingly recognised, patients considered at risk for ICDs development may not have been prescribed a DA 17.…”

Section: Discussionmentioning

confidence: 99%

ICARUS study: prevalence and clinical features of impulse control disorders in Parkinson’s disease

Antonini

Barone

Bonuccelli

et al. 2017

J Neurol Neurosurg Psychiatry

123

147

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Section: Discussionmentioning

confidence: 99%

ICARUS study: prevalence and clinical features of impulse control disorders in Parkinson’s disease

Antonini

Barone

Bonuccelli

et al. 2017

J Neurol Neurosurg Psychiatry

123

147

View full text Add to dashboard Cite

show abstract

“…On the other hand, another recent study compared pd patients (with and without gambling disorder) based on the personality profile of the Minnesota Multiphasic Personality Inventory-2 (mmpi-2) and found that pd subjects with gambling disorder displayed higher values on the validity scales and some content scales (Brusa et al, 2016). Finally, a current revision work (Heiden, Heinz, & RomanczukSeiferth, 2017) confirmed the higher comorbidity of gambling disorder in pd patients compared to the general population.…”

Section: Description Of Gambling Disorder: Characteristics and Comorbmentioning

confidence: 93%

“…A recent research contrasted two groups of subjects: pd patients with gambling disorder history (n = 37), and pd patients without gambling disorder (matched for disease and dopaminergic therapy) that serve as controls (n = 21), based on the personality profile of the mmpi-2 (Brusa et al, 2016). The study found that pd patients with gambling disorder displayed higher values on the validity scales (L, F, and K) and specific content scales (cynicism and bizarre ideation) compared to the control group; this personality profile fits more in the cluster A personality disturbance of the dsm-5.…”

Section: Overview Of the Experimental Work About The Relationship Betmentioning

confidence: 99%

“…The study found that pd patients with gambling disorder displayed higher values on the validity scales (L, F, and K) and specific content scales (cynicism and bizarre ideation) compared to the control group; this personality profile fits more in the cluster A personality disturbance of the dsm-5. According to Brusa et al's report, potential consequences of starting dopaminergic treatment in pd patients with this personality profile should be considered, because of the potential risk of displaying gambling disorder (or other impulse control disorders; Brusa et al, 2016).…”

Section: Overview Of the Experimental Work About The Relationship Betmentioning

confidence: 99%

“…5) A potential approach for treating gambling disorder and other impulse control disorders in pd patients is the activation of the subthalamic nucleus combined with the reduction of dopaminergic treatment (Castrioto et al, 2015). 6) In terms of neuropsychological and psychometric characteristics, the studies showed that pd sufferers with a gambling disorder (compared to those without a gambling disorder) displayed more impairment in visual spatial memory (at a long term range), disruption of frontal brain functioning (Santangelo et al, 2009); disruption in sets shifting and spatial planning (Vitale et al, 2011); higher scores in the validity scales (L, F and K) and content scales (cynicism and bizarre ideation) of the mmpi-2 (Brusa et al, 2016). However, another study differed (Siri et al, 2010), and instead found intact cognitive functioning in pd patients with a gambling disorder.…”

Section: Conclusion Of the Experimental Work About The Association Bmentioning

confidence: 99%

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A Revision of the Relationship between Gambling Disorder, Attention Deficit Hyperactivity Disorder and Parkinson´s Disease

Quintero-Garzola¹

2017

Pensando Psicol.

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Purpose: For the present review, publications in the field of gambling disorder that deal with its relationships with others, mainly attention deficit hyperactivity disorder (adhd) and Parkinson's disease (pd) were consulted. Methods: The current revision includes a total of 63 references published between 1987 and 2017. It included human studies and revisions regarding the comorbidity of gambling disorder with adhd or pd. The search terms included: gambling disorder, gambling disorder comorbidity, gambling disorder and adhd, gambling disorder and pd, gambling disorder and impulsivity. The present review focused on the link among gambling disorder and adhd or pd, because there were a large number of publications related to these disorders. For organization purpose the current work was split into two main parts: 1) Revision of previous scientific reviews about gambling disorder, and 2) Overview and conclusions of experimental work about gambling disorder. Conclusions: The principal conclusions of the current review are: 1) subjects with a gambling disorder have a higher incidence of adhd (and also of attention deficit disorder [add]), 2) the presence of adhd in subjects that suffer of gambling disorder implies more challenges for the health care system, and 3) pd treatments that increase the agonism of dopamine type of receptor are related to an elevated probability for developing a gambling problem or an impulse control disorder.Keywords: adhd, comorbidity, disorder, dopamine receptor, gambling pd. ResumenObjetivo: para la presente revisión, se consultaron publicaciones en el campo de la ludopatía que tratan de sus relaciones con otros trastornos, principalmente el trastorno por déficit de atención con hiperactividad (tdah) y la enfermedad de Parkinson (ep). Método: la presente revisión tiene en cuenta 63 referencias publicadas entre 1987 y 2017 y tuvo en cuenta estudios en humanos y revisiones sobre la comorbilidad de la ludopatía con el tdah o la ep. Los términos de la búsqueda incluyeron: ludopatía, comorbilidad de la ludopatía, ludopatía y tdah, ludopatía y ep, ludopatía e impulsividad. Esta revisión se centró en el vínculo entre la ludopatía y el tdah o la ep, puesto que existía un gran número de publicaciones relacionadas con estos trastornos. Para su organización, el presente trabajo se dividió en dos partes principales: 1) el análisis de revisiones científicas anteriores sobre la ludopatía y 2) el resumen y las conclusiones del trabajo experimental sobre la ludopatía. Conclusiones: las conclusiones principales de esta revisión son: 1) los sujetos con ludopatía tienen una mayor incidencia del tdah (y también del trastorno de déficit de atención [tda]), 2) la presencia del tdah en sujetos que sufren de ludopatía implica más retos para el sistema de salud y 3) los tratamientos de la ep que aumentan el agonismo del receptor tipo dopamina están relacionados con una probabilidad elevada de desarrollar un problema de juego o un trastorno de control de impulsos.Palabras clave: tdah, comorbilidad, trasto...

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Impulse control behaviors and subthalamic deep brain stimulation in Parkinson disease

et al. 2016

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To determine the clinical and demographic correlates of persistent, remitting, and new-onset impulse control behaviors (ICBs) before and after subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We compared the pre- and post-surgical prevalence of ICBs, classified as impulse control disorders (ICD), dopamine dysregulation syndrome (DDS), and punding in 150 consecutive PD STN-DBS-treated patients and determined the association with motor, cognitive, neuropsychological, and neuropsychiatric endpoints. At baseline (before STN-DBS), ICBs were associated with younger age (p = 0.045) and male gender (85 %; p = 0.001). Over an average follow-up of 4.3 ± 2.1 years of chronic STN-DBS there was an overall trend for reduction in ICBs (from 17.3 to 12.7 %; p = 0.095) with significant improvement in hypersexuality (12-8.0 %; p = 0.047), gambling (10.7-5.3 %; p = 0.033), and DDS (4.7-0 %; p < 0.001). ICB remitted in 18/26 patients (69 %) and persisted in 8/26 (31 %); the latter group was characterized by higher levodopa equivalent daily dose. Patients who developed a new-onset ICB during follow-up (n = 11/150) were characterized by younger age (p = 0.042), lower dyskinesia improvement (p ≤ 0.035), and a gender distribution with higher prevalence of women (p = 0.018). In addition, new-onset ICB was more common among patients with borderline, schizoid, and/or schizotypal traits of personality disorders; persistent ICB in those with obsessive-compulsive traits. PD-related ICBs exhibit a complex outcome after STN-DBS, with a tendency for overall reduction but with age, gender, dopaminergic therapy, and neuropsychiatric features exerting independent effects.

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Pathological Gambling in Parkinson's disease patients: Dopaminergic medication or personality traits fault?

Cited by 13 publications

References 7 publications

ICARUS study: prevalence and clinical features of impulse control disorders in Parkinson’s disease

ICARUS study: prevalence and clinical features of impulse control disorders in Parkinson’s disease

A Revision of the Relationship between Gambling Disorder, Attention Deficit Hyperactivity Disorder and Parkinson´s Disease

Impulse control behaviors and subthalamic deep brain stimulation in Parkinson disease

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