Role of renal function in cardiovascular risk assessment: A retrospective cohort study in a population with low incidence of coronary heart disease

García-Gil, Maria; Parramon, Dídac; Comas-Cufí, Marc; Martí, Ruth; Ponjoan, Anna; Alves-Cabratosa, Lia; Blanch, Jordi; Petersen, Irene; Elosúa, Roberto; Grau, María; Salvador, Betlem; Ramos, Rafael

doi:10.1016/j.ypmed.2016.06.004

Cited by 7 publications

(6 citation statements)

References 43 publications

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“…SIDIAP comprises electronic medical records, including comprehensive demographic information, clinical diagnoses, referral and hospitalizations. The high quality of these data has been previously documented [21, 22], specifically for cardiovascular risk factors and diseases [23, 24]. …”

Section: Methodsmentioning

confidence: 99%

“…We used the self-controlled case series (SCCS) methodology [23] to assess the relative incidence rate ratios (IRRs) of hospitalizations during periods of extreme temperature exposure in comparison to reference time periods with normal temperature exposure. Since comparisons are made within individuals, the SCCS relies on conditional Poisson regression to calculate IRR and 95% confidence intervals (CIs).…”

Section: Methodsmentioning

confidence: 99%

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Effects of extreme temperatures on cardiovascular emergency hospitalizations in a Mediterranean region: a self-controlled case series study

et al. 2017

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BackgroundCold spells and heatwaves increase mortality. However little is known about the effect of heatwaves or cold spells on cardiovascular morbidity. This study aims to assess the effect of cold spells and heatwaves on cardiovascular diseases in a Mediterranean region (Catalonia, Southern Europe).MethodsWe conducted a population-based retrospective study. Data were obtained from the System for the Development of Research in Primary Care and from the Catalan Meteorological Service. The outcome was first emergency hospitalizations due to coronary heart disease, stroke, or heart failure. Exposures were: cold spells; cold spells and 3 or 7 subsequent days; and heatwaves. Incidence rate ratios (IRR) and 95% confidence intervals were calculated using the self-controlled case series method. We accounted for age, time trends, and air pollutants; results were shown by age groups, gender or cardiovascular event type.ResultsThere were 22,611 cardiovascular hospitalizations in winter and 17,017 in summer between 2006 and 2013. The overall incidence of cardiovascular hospitalizations significantly increased during cold spells (IRR = 1.120; CI 95%: 1.10–1.30) and the effect was even stronger in the 7 days subsequent to the cold spell (IRR = 1.29; CI 95%: 1.22–1.36). Conversely, cardiovascular hospitalizations did not increase during heatwaves, neither in the overall nor in the stratified analysis.ConclusionsCold spells but not heatwaves, increased the incidence of emergency cardiovascular hospitalizations in Catalonia. The effect of cold spells was greater when including the 7 subsequent days. Such knowledge might be useful to develop strategies to reduce the impact of extreme temperature episodes on human health.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0238-0) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effects of extreme temperatures on cardiovascular emergency hospitalizations in a Mediterranean region: a self-controlled case series study

et al. 2017

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“…M-mode echocardiography, quantitative 2-dimensional (biplane Simpson) method and semiquantitative 2-dimensional visual estimate method were used to quantitate ejection fraction 15 . As there was a high correlation between these 3 methods, visual estimate ejection fraction was used in the final interpretation 4 . To quantitate the LV mass, standard formulas based on M-mode measurement of diastolic dimension and wall thickness were used.…”

Section: Echocardiographymentioning

confidence: 99%

“…Chronic kidney disease is widely prevalent and associated with a poor prognosis, which can be largely attributed to cardiovascular mortality and morbidity 1 . Cardiovascular disease (CVD) has long been identified as the major cause of premature death in CKD, even with mildly impaired renal function [2][3][4][5] . This can be explained in part by shared common risk factors including hypertension, diabetes, hyperlipidemia, smoking and obesity.…”

Section: Introductionmentioning

confidence: 99%

Estimated Glomerular Filtration Rate, Activation of Cardiac Biomarkers and Long-Term Cardiovascular Outcomes: A Population-Based Cohort

Vinnakota

Scott

Rodeheffer

et al. 2019

Mayo Clinic Proceedings

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Objective-To classify subjects in a general population per their renal function and characterize the cardiac biomarker levels, LV function and cardiovascular outcomes over a 10.2 year follow up (IQR: 5.1-11.4).Patients and Methods-This was a retrospective review of a population-based random sample of residents aged ≥45 years. Data was collected between January 1, 1997 and December 31, 2000). 1981 individuals were classified based on eGFR into group I (>90 mL/min/1.73m 2 ), group II (60-89 mL/min/1.73m 2 ) and group III (<60; CKD mL/min/1.73m 2 ). Age/gender-adjusted baseline characteristics, tertiles of NT-proBNP and hs-TnT and their interactions with eGFR were examined. Outcomes measured included incident MI, CHF, stroke and all-cause mortality.Results-819 were classified as Group I, 1036 as Group II and 126(6.4%) as Group III or CKD. Subjects in Group III were older and had a higher incidence of hypertension, diabetes and MI at baseline. Over a 10.2-year follow-up, CKD was associated with an increased risk of MI [HR: 1.95(1.2-3.14);P=.006] and composite cardiovascular outcomes including MI, CHF, stroke and all-cause mortality [HR: 1.38(1.05-1.83);P=.02]. Subjects with NT-proBNP or hs-TnT in the third tertile were at greater risk of cardiovascular events without significant interactions between eGFR and levels of NT-proBNP and hs-TnT.Conclusions-Subjects with CKD had significantly elevated cardiac biomarkers and were at an increased risk of MI and adverse cardiovascular events. This warrants future studies to investigate if these cardiac biomarkers could identify high-risk CKD patients for aggressive management of cardiovascular risk factors.

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“…Cause of donor death plays a major role in graft quality and outcomes after kidney transplantation. The cause of donor death is associated with renal function of the donor because adequate renal function protects against adverse cardiovascular events [10]. The authors have mentioned this as a limitation of their study, and it reveals the suboptimal quality of data registration in EuroTransplant.…”

mentioning

confidence: 95%

Invited commentary: advantages and cautions for developing valid prognostic models of simultaneous pancreas and kidney transplantation outcomes

Mehrabi

Khajeh

Zeier

2018

Langenbecks Arch Surg

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Role of renal function in cardiovascular risk assessment: A retrospective cohort study in a population with low incidence of coronary heart disease

Cited by 7 publications

References 43 publications

Effects of extreme temperatures on cardiovascular emergency hospitalizations in a Mediterranean region: a self-controlled case series study

Effects of extreme temperatures on cardiovascular emergency hospitalizations in a Mediterranean region: a self-controlled case series study

Estimated Glomerular Filtration Rate, Activation of Cardiac Biomarkers and Long-Term Cardiovascular Outcomes: A Population-Based Cohort

Invited commentary: advantages and cautions for developing valid prognostic models of simultaneous pancreas and kidney transplantation outcomes

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