Immunobiotic Lactobacillus strains reduce small intestinal injury induced by intraepithelial lymphocytes after Toll-like receptor 3 activation

Tada, Asuka; Zelaya, Hortensia; Clua, Patricia; Salva, Susana; Álvarez, Susana; Kitazawa, Haruki; Villena, Julio

doi:10.1007/s00011-016-0957-7

Cited by 37 publications

(65 citation statements)

References 41 publications

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“…Recently, we confirmed in vivo the differential antiviral immunomodulatory activities triggered by L. rhamnosus CRL1505 and L. plantarum CRL1506 (65). Both strains increased the production of IFNs, the CRL1505 treatment being the most effective for increasing the levels of IFN-γ.…”

Section: Cellular and Molecular Mechanisms Of Immunobiotics Actionssupporting

confidence: 56%

“…Therefore, TLR3 signaling stimulates IECs to express IL-15 and RAE1 and induces CD3 + NK1.1 + CD8αα + IELs to express NKG2D through IEC-derived IL-15. In our hands, poly(I:C) treatment of mice increased intestinal injury in a IL-15- and CD8αα + NKG2D + -dependent manner (65). Poly(I:C) induced inflammatory-mediated intestinal tissue damage through the increase of CD3 + NK1.1 + and CD8αα + NKG2D + cells as well as proinflammatory mediators (TNF-α, IL-1β, IFN-γ, IL-15, RAE1, IL-8).…”

Section: Cellular and Molecular Mechanisms Of Immunobiotics Actionsmentioning

confidence: 77%

“…Lactobacillus rhamnosus CRL1505 and L. plantarum CRL1506 also reduced TLR3-induced small intestinal injury by regulation of proinflammatory cytokines production and IECs–IELs interaction (65) (Figure 5). IECs and IELs are the first line of defense against pathogens including viruses, and their interaction is essential for maintaining an appropriate immunological homeostasis.…”

Section: Cellular and Molecular Mechanisms Of Immunobiotics Actionsmentioning

confidence: 99%

“…Moreover, we performed comparative studies with another immunobiotic strain, Lactobacillus plantarum CRL1506, that is able stimulate intestinal immunity in animal models (65). Studies comparing the immunobiotic strains L. rhamnosus CRL1505 and L. plantarum CRL1506 in co-cultures of PIE cells and APCs, stimulated with poly(I:C), showed that both strains improved the production of type I IFNs in response to poly(I:C) challenge (66).…”

Section: Cellular and Molecular Mechanisms Of Immunobiotics Actionsmentioning

confidence: 99%

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Intestinal Innate Antiviral Immunity and Immunobiotics: Beneficial Effects against Rotavirus Infection

2016

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The mucosal tissues of the gastrointestinal tract are the main portal entry of pathogens such as rotavirus (RV), which is a leading cause of death due to diarrhea among young children across the globe and a major cause of severe acute intestinal infection in livestock animals. The interactions between intestinal epithelial cells (IECs) and immune cells with RVs have been studied for several years, and now, it is known that the innate immune responses triggered by this virus can have both beneficial and detrimental effects for the host. It was demonstrated that natural RV infection in infants and experimental challenges in mice result in the intestinal activation of pattern recognition receptors (PRRs) such as toll-like receptor 3 (TLR3) and striking secretion of proinflammatory mediators that can lead to increased local tissue damage and immunopathology. Therefore, modulating desregulated intestinal immune responses triggered by PRRs activation are a significant promise for reducing the burden of RV diseases. The ability of immunoregulatory probiotic microorganisms (immunobiotics) to protect against intestinal infections, such as those caused by RVs, is among the oldest effects studied for these important group of beneficial microbes. In this review, we provide an update of the current status on the modulation of intestinal antiviral innate immunity by immunobiotics and their beneficial impact on RV infection. In addition, we describe the research of our group that demonstrated the capacity of immunobiotic strains to beneficially modulated TLR3-triggered immune response in IECs, reduce the disruption of intestinal homeostasis caused by intraepithelial lymphocytes, and improve the resistance to RV infections.

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Section: Cellular and Molecular Mechanisms Of Immunobiotics Actionssupporting

confidence: 56%

Section: Cellular and Molecular Mechanisms Of Immunobiotics Actionsmentioning

confidence: 77%

Section: Cellular and Molecular Mechanisms Of Immunobiotics Actionsmentioning

confidence: 99%

Section: Cellular and Molecular Mechanisms Of Immunobiotics Actionsmentioning

confidence: 99%

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Intestinal Innate Antiviral Immunity and Immunobiotics: Beneficial Effects against Rotavirus Infection

2016

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“…Exposure to two different strains of Lactobacillus reduced epithelial expression of IL-15 and the NKG2D ligand Rae1 (retinoic acid early inducible-1) to alleviate TLR3-mediated increases in CD8αα IEL number and NKG2D expression. [61] Further, prophylactic administration of a probiotic mixture containing Lactobacillus acidophilus and Bifidobacterium longum conferred protection against TNBS colitis, which was associated with reduced CD4 + T cells and increased γδ T cells in the intraepithelial compartment. Interestingly, the inverse distribution of these cells was observed in the lamina propria in response to TNBS in probiotic-treated mice.…”

Section: Commensal Bacteria Influence Iel Development and Functionmentioning

confidence: 99%

Sentinels at the Frontline: the Role of Intraepithelial Lymphocytes in Inflammatory Bowel Disease

Edelblum

2017

Curr Pharmacol Rep

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Purpose of review Intestinal mucosal immunity is tightly regulated to ensure effective host defense against invasive microorganisms while limiting the potential for aberrant damage. In inflammatory bowel disease (IBD), an imbalance between effector and regulatory T cell populations results in an uncontrolled inflammatory response to commensal bacteria. Intraepithelial lymphocytes (IEL) are perfectly positioned within the intestinal epithelium to provide the first line of mucosal defense against luminal microbes or rapidly respond to epithelial injury. This review will highlight how IELs promote protective intestinal immunity and discuss the evidence indicating that altered IEL responses contribute to the pathogenesis of IBD. Recent findings Although the role of IELs in mucosal homeostasis has been largely underappreciated, many of the same factors that contribute to the dysregulation of host defense in IBD also adversely affect IELs. For example, IL-23 and the endoplasmic reticulum stress response can enhance IEL lytic activity toward enterocytes. Microbial dysbiosis or defective microbial recognition results in the loss of regulatory IELs, further amplifying these pro-inflammatory effects. Migration of T cells into or within the intraepithelial compartment has a profound effect on their differentiation or effector function demonstrating that IELs are exquisitely sensitive to changes in the local intestinal microenvironment. Summary Enhanced mechanistic insight into the regulation of IEL survival, differentiation and effector function may provide useful tools to modulate IEL surveillance or enhance IEL regulatory function. Elucidation of these processes may result in the development of novel therapeutics to reduce intestinal inflammation and reinforce the mucosal barrier in IBD.

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Microbes in Pharmaceutical Industry

Kapoor

Sharma

et al. 2020

Microbial Diversity, Interventions and Scope

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Immunobiotic Lactobacillus strains reduce small intestinal injury induced by intraepithelial lymphocytes after Toll-like receptor 3 activation

Cited by 37 publications

References 41 publications

Intestinal Innate Antiviral Immunity and Immunobiotics: Beneficial Effects against Rotavirus Infection

Intestinal Innate Antiviral Immunity and Immunobiotics: Beneficial Effects against Rotavirus Infection

Sentinels at the Frontline: the Role of Intraepithelial Lymphocytes in Inflammatory Bowel Disease

Microbes in Pharmaceutical Industry

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